Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review

Helánová, Kateřina; Špinar, Jindřich; Pařenica, Jiří

doi:10.1159/000368474

Cited by 75 publications

(88 citation statements)

References 37 publications

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“…In short, NGAL is one of the most valuable biomarkers for monitoring AKI, with high sensitivity and specificity [80], but it is easily affected by various interference factors, which seems to be more applicable for AKI patients with relatively fewer complications.…”

Section: Kidney Injury Molecule 1 (Kim-1)mentioning

confidence: 99%

Early Predictors of Acute Kidney Injury: A Narrative Review

Liu

Guan

et al. 2016

Kidney Blood Press Res

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Accompanied with the broad application of interventional therapy, the incidence of acute kidney injury (AKI) has been recently increasing in clinical renal medicine. The pathogenesis of AKI is diverse and complex. In the context of the requirements for the diagnosis and treatment of a renal disorder, a large number of studies have explored biological markers and their usefulness to the early diagnosis and treatment of AKI, including glomerular injury, renal tubular injury, and others. These biomarkers provide an important basis for early monitoring of AKI, but are still not quite sufficient. More ideal biomarkers are needed to be identified. Therefore, future studies are necessary to explore more effective biomarkers for AKI clinical practice, which would play an important role in the early diagnosis and intervention treatment of AKI. This review summarizes the important biomarkers identified by previous studies and aims to highlight the advancements that might provide new methods for early clinical diagnosis and effective therapeutic options, along with prediction of response to treatment for AKI.

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Section: Kidney Injury Molecule 1 (Kim-1)mentioning

confidence: 99%

Early Predictors of Acute Kidney Injury: A Narrative Review

Liu

Guan

et al. 2016

Kidney Blood Press Res

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“…Plasma neutrophil gelatinase-associated lipocalin (NGAL), urinary liver-type fatty acidbinding protein (L-FABP) and urinary kidney injury molecule-1 (KIM-1) have emerged as promising diagnostic and prognostic biomarkers for both acute and chronic kidney injury in different clinical settings [7][8][9][10][11][12][13][14]. Moreover, several studies have shown that these markers may also provide a prognostic value for cardiovascular morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Early Biomarkers of Renal Damage in Relation to Arterial Stiffness and Inflammation in Male Coronary Artery Disease Patients

Paapstel

Zilmer²,

Eha³

et al. 2016

Kidney Blood Press Res

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Background/Aims: Plasma neutrophil gelatinase-associated lipocalin (NGAL), urinary liver-type fatty acid-binding protein (L-FABP) and urinary kidney injury molecule-1 (KIM-1) have emerged as promising biomarkers for both acute and chronic kidney injury that also provide prognostic value for cardiovascular morbidity and mortality. Our aim was to evaluate their relationships with arterial stiffness and inflammation in coronary artery disease (CAD) patients and in clinically healthy controls. Methods: We studied 52 patients with CAD (age 63.2 ± 9.2 years) and 41 healthy controls (age 60.1 ± 7.2 years). Urinary L-FABP and KIM-1 as well as serum NGAL, adiponectin and resistin levels were measured using the enzyme-linked immunosorbent assay method. The technique of applanation tonometry was used for non-invasive pulse wave analysis and pulse wave velocity assessments. Results: Urinary L-FABP and KIM-1 were independent determinants of cf-PWV for the CAD patients (R²=0.584, P<0.001) but not for the controls. Adiponectin correlated with log-KIM-1 (r=0.31, P=0.028) only for the patients, while NGAL correlated with WBC count (rho=0.29, P=0.038; r=0.35, P=0.029) and resistin (rho=0.60, P<0.001; r=0.57, P<0.001) for both the CAD and control groups, respectively. Conclusion: Our findings suggest that urinary L-FABP and KIM-1 may be independently associated with aortic stiffness in individuals with CAD.

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“…It plays a significant role in cardiovascular diseases. Elevated levels of NGAL have been found in patients with hypertension, ischemic heart disease, cerebrovascular disease and cancer [4]. Several studies have shown its prognostic value in patients with myocardial infarction and heart failure [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…One of the functions of NGAL is the formation of a complex with matrix metalloproteinase 9 (MMP-9) [7]. By forming the MMP-NGAL complex, NGAL protects MMP-9 from proteolytic degradation increasing the enzymatic activity of MMP-9, which may cause fibrosis and cardiac remodeling [4,8]. Several studies have indicated that remodeling of atria contributes to the recurrence or perpetuation of AF [3].…”

Section: Introductionmentioning

confidence: 99%

Matrix Metalloproteinase Neutrophil Gelatinase-Associated Lipocalin Complex Predicts Atrial Fibrillation Recurrence after Electrical Cardioversion in Obese Patients

et al. 2016

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Background: There is not much data on matrix metalloproteinase neutrophil gelatinase-associated lipocalin (MMP-NGAL) complex in patients with atrial fibrillation (AF). Aim: The aim of the study was to assess the value of MMP-NGAL complex in predicting AF recurrence after electrical cardioversion. Methods: The serum levels of NGAL, cystatin C, interleukin-6, high-sensitivity C-reactive protein, copeptin, MMP-NGAL complex, matrix metalloproteinase 2, tissue inhibitor of metalloproteinase 1, Von Willebrand factor, B-type natriuretic peptide and the urinary level of NGAL were evaluated before cardioversion. Results: A total of 83 patients with persistent AF were enrolled in the study. Left atrial diameter (LA) ≥4.5 cm was significantly associated with AF recurrence at follow-up (p = 0.009). In selected 39 obese patients, MMP-NGAL complex was associated with AF recurrence (p = 0.03). If the concentration of MMP-NGAL complex increased by 1 ng/ml, the odds of AF recurrence increased by 4% (OR 1.04; CI: 1.00-1.08; p = 0.03). MMP-NGAL complex did not correlate with AF recurrence in patients with a first episode of AF, in patients ≥65 years of age and in patients with a LA ≥4.5 cm or with chronic kidney disease. Conclusions: It is known that the greater the BMI at baseline, the higher the likelihood of progression from paroxysmal to permanent AF. However, European Society of Cardiology (ESC) guidelines do not consider obese patients a population with a low likelihood of success of cardioversion. That is why we need a sensitive marker to predict sinus rhythm maintenance in such a population. We found that MMP-NGAL complex may predict AF recurrence after successful cardioversion in obese patients.

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Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review

Cited by 75 publications

References 37 publications

Early Predictors of Acute Kidney Injury: A Narrative Review

Early Predictors of Acute Kidney Injury: A Narrative Review

Early Biomarkers of Renal Damage in Relation to Arterial Stiffness and Inflammation in Male Coronary Artery Disease Patients

Matrix Metalloproteinase Neutrophil Gelatinase-Associated Lipocalin Complex Predicts Atrial Fibrillation Recurrence after Electrical Cardioversion in Obese Patients

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