Diagnostic and Prognostic Value of Erythrocyte Sedimentation Rate in Contiguous Osteomyelitis of the Foot and Ankle

Rabjohn, Linnie; Roberts, Kenneth M.; Troiano, Michael; Schoenhaus, Harold D.

doi:10.1053/j.jfas.2007.03.004

Cited by 31 publications

(22 citation statements)

References 21 publications

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“…In that study, 43% of the patients had a more superficial ulcer (Wagner 0–2 ) compared to our patient population. Rabjohn et al had similar pre‐operative levels of ESR in their osteomyelitis group (76·2 ± 35·7 mm/hours) and in their control group (59·2 ± 24·7 mm/hours) as our study population and found a significant difference between DFO and NDFO patients ( P = 0·022). However, comparison with that population is difficult because patients without diabetes were also included in the analyses.…”

Section: Discussionsupporting

confidence: 74%

The value of inflammatory markers to diagnose and monitor diabetic foot osteomyelitis

Asten

Nichols

Fontaine

et al. 2015

International Wound Journal

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In this study, we assessed the effectiveness of inflammatory markers to diagnose and monitor the treatment of osteomyelitis in the diabetic foot. We evaluated 35 consecutive patients admitted to our hospital with infected foot ulcers. Patients were divided in two groups based on the results of bone culture and histopathology: osteomyelitis and no osteomyelitis. The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor alpha (TNFα), monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-1 alpha (MIP1α) were measured at baseline after 3 and 6 weeks of standard therapy. PCT levels in the osteomyelitis group were significantly higher at baseline than in the group with no osteomyelitis (P = 0·049). There were no significant differences between the two groups in the levels of the other markers. CRP, ESR, PCT and IL-6 levels significantly declined in the group with osteomyelitis after starting therapy, while MCP-1 increased (P = 0·002). TNFα and MIP1α levels were below range in 80 out of 97 samples and therefore not reported. Our results suggest that PCT might be useful to distinguish osteomyelitis in infected foot ulcers. CRP, ESR, PCT and IL-6 are valuable when monitoring the effect of therapy.

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Section: Discussionsupporting

confidence: 74%

The value of inflammatory markers to diagnose and monitor diabetic foot osteomyelitis

Asten

Nichols

Fontaine

et al. 2015

International Wound Journal

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“…The measurement of erythrocyte sedimentation rate (ESR) has been widely used for over 50 years as a simple, standardized medical screening test 15–20. Although many modifications have been made to speedup the procedure,21–23 the basic operational principle is the same.…”

Section: Introductionmentioning

confidence: 99%

A simple apparatus for measuring cell settling velocity

Wang

Belovich

2010

Biotechnology Progress

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Accurate cell settling velocity determination is critical for perfusion culture using a gravity settler for cell retention. We have developed a simple apparatus (a “settling column”) for measuring settling velocity and have validated the procedure with 15‐μm polystyrene particles with known physical properties. The measured settling velocity of the polystyrene particles is within 4% of the value obtained using the traditional Stokes' law approach. The settling velocities of three hybridoma cell lines were measured, resulting in up to twofold variation among cell lines, and the values decreased as the cell culture aged. The settling velocities of the nonviable cells were 33–50% less than the corresponding viable cells. The significant variation of settling velocities among cell populations and growth phases confirms the necessity of routine measurement of this property during long‐term perfusion culture. © 2010 American Institute of Chemical Engineers Biotechnol. Prog., 2010

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“…Rabjohn et al . prospectively studied the use of ESR in lower extremity OM as a result of trauma or diabetic ulcers 22 . He found that using a cut‐off of 70 mm/h resulted in a PPV (positive predictive value) of 82.6% (excluding patients with factors known to elevate ESR – see Table 3).…”

Section: Resultsmentioning

confidence: 99%

Review article: How useful are laboratory investigations in the Emergency Department evaluation of possible osteomyelitis?

Harris

Caesar

Davison

et al. 2011

Emerg Medicine Australasia

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We conducted a literature review to determine which laboratory investigations are useful for the ED evaluation of osteomyelitis. Thirty-six relevant papers were identified. We concluded that in adult and paediatric patients with a clinically low level of suspicion of osteomyelitis, an age-adjusted normal erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) <5 mg/L should reassure the clinician that no further urgent investigation is required. For patients with risk factors for osteomyelitis or a clinically high level of suspicion, a normal ESR or CRP <5 mg/L should not rule out the diagnosis of osteomyelitis, especially in patients with puncture wounds or foot ulcers/infections. In patients with any suspicion of osteomyelitis and otherwise unexplained ESR >30 mm/h and/or CRP >10-30 mg/L further definitive investigation is required. The white blood count is not helpful in the evaluation of osteomyelitis.

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Diagnostic and Prognostic Value of Erythrocyte Sedimentation Rate in Contiguous Osteomyelitis of the Foot and Ankle

Cited by 31 publications

References 21 publications

The value of inflammatory markers to diagnose and monitor diabetic foot osteomyelitis

The value of inflammatory markers to diagnose and monitor diabetic foot osteomyelitis

A simple apparatus for measuring cell settling velocity

Review article: How useful are laboratory investigations in the Emergency Department evaluation of possible osteomyelitis?

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