Diagnostic and prognostic value of<scp>circRNAs</scp>expression in head and neck squamous cell carcinoma: A meta‐analysis

Feng, Hao; Wang, Dingting; Liu, Jinping; Zou, Longfei; Xu, Shengen; Zeng, Liang; Qin, Gang

doi:10.1002/jcla.24496

Cited by 2 publications

(2 citation statements)

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“…Regarding tumor size, the cutoff values ranged from 3 to 7 cm (most of the included studies used the cutoff value of 5 cm to classify the tumors based on their size). In line with previous meta‐analyses, we defined older and younger groups for age and smaller and larger groups for tumor size according to the categories of the included studies 28,29 . The number of patients in high‐and low‐expression groups of the circRNAs for these endpoints, and p ‐values for the chi‐squared test comparing the high‐ and low‐expression groups were gathered.…”

Section: Methodsmentioning

confidence: 99%

“…In line with previous meta-analyses, we defined older and younger groups for age and smaller and larger groups for tumor size according to the categories of the included studies. 28,29 The number of patients in high-and low-expression groups of the circRNAs for these endpoints, and p-values for the chi-squared test comparing the high-and low-expression groups were gathered.…”

Section: Data Extraction and Outcome Definitionmentioning

confidence: 99%

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Circular RNAs as prognostic and diagnostic biomarkers in renal cell carcinoma

Rashedi

Mardani

Rafati

et al. 2022

Clinical Laboratory Analysis

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Background Circular RNAs (circRNAs) play pivotal roles in proliferation, apoptosis, migration, and invasion of renal cell carcinoma (RCC) cells. This study is aimed to systematically summarize the current evidence regarding the clinical implications of circRNAs in RCC patients. Methods A systematic search in PubMed, Embase, and Web of Science was performed until January 1, 2022. The correlation between the expression of circRNAs and clinicopathological, prognostic, and diagnostic features of RCC was evaluated using the meta‐analysis. Results Ultimately, 41 studies with 3485 RCC patients were included in this study: 26 studies for clinicopathological features, 31 studies for prognosis, and eight studies for diagnosis. Altered expression of circRNAs was significantly associated with clinicopathological characteristics of RCC, including tumor size, tumor stage, lymph node metastasis, distant metastasis, and TNM stage. The tumor promoter circRNAs were associated with reduced overall survival (OS) (Hazard Ratio (HR) = 1.98, 95% confidence interval [CI] 1.68–2.34) and disease/progression/recurrence‐free survival (DFS/PFS/RFS) (HR = 2.34, 95% CI 1.85–2.97). Contrarily, the tumor suppressor circRNAs were linked with better OS (HR = 0.49, 95% CI 0.40–0.60) and DFS/PFS/RFS (HR = 0.40, 95% CI 0.28–0.59). The pooled sensitivity and specificity of circRNAs for RCC diagnosis in tissue samples were both 0.84. These results in fluid samples (serum and urine) were 0.78 and 0.69, respectively. Conclusion CircRNAs can serve as promising diagnostic and prognostic biomarkers for RCC.

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Section: Methodsmentioning

confidence: 99%

Section: Data Extraction and Outcome Definitionmentioning

confidence: 99%