Diagnostic and prognostic value of plasma microRNA deregulation in nasopharyngeal carcinoma

Liu, Xiong; Luo, Hua; Tian, Wen; Lü, Juan; Li, Gang; Wang, Lu; Bao, Zhenmin; Liang, Bishan; Peng, Xiao Hong; Lin, Shao Xiong; Peng, Ying; Li, Xiang Ping

doi:10.4161/cbt.26170

Cited by 62 publications

(60 citation statements)

References 37 publications

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“…While NPC miRNA expression studies have highlighted the importance and potential roles of miRNAs in disease, a deeper understanding is needed (Liu et al, 2013b). miR-183-5p was reported to be an early predictive biomarker for prostate cancer with aggressive progression characteristics (Larne et al, 2013), while conversely in lung cancer its expression was decreased .…”

Section: Discussionmentioning

confidence: 99%

“…Due to its unique location and a lack of specific symptoms, NPC is rarely detected during regular medical examinations and is often highly invasive in the late stages (Guo et al, 2013;Liu et al, 2013b). If these patients are diagnosed earlier or if relapses can be predicted sooner, clinical management would be greatly improved (Lin et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Five miRNAs as Novel Diagnostic Biomarker Candidates for Primary Nasopharyngeal Carcinoma

Tang¹,

Zhong²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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MicroRNAs (miRNAs) play an essential role in the development and progression of nasopharyngeal carcinomas (NPC). Despite advances in the field of cancer molecular biology and biomarker discovery, the development of clinically validated biomarkers for primary NPC has remained elusive. In this study, we investigated the expression and clinical significance of miRNAs as novel primary NPC diagnostic biomarkers. We used an array containing 2, 500 miRNAs to identify 22 significant miRNAs, and these candidate miRNAs were validated using 67 fresh NPC and 25 normal control tissues via quantitative real-time PCR (qRT-PCR). Expression and correlation analyses were performed with various statistical approaches, in addition to logistic regression and receiver operating characteristic curve analyses to evaluate diagnostic efficacy. qRT-PCR revealed five differentially expressed miRNAs (miR-93-5p, miR-135b-5p, miR-205-5p and miR-183-5p) in NPC tissue samples relative to control samples (p<0.05), with miR-135b-5p and miR-205-5p being of significant diagnostic value (p<0.01). Moreover, comparison of NPC patient clinicopathologic data revealed a negative correlation between miR-93-5p and miR-183-5p expression levels and lymph node status (p<0.05). These findings display an altered expression of many miRNAs in NPC tissues, thus providing information pertinent to pathophysiological and diagnostic research. Ultimately, miR-135b-5p and miR-205-5p may be implicated as novel NPC candidate biomarkers, while miR-93-5p, miR-650 and miR-183-5p may find application as relevant clinical pathology and diagnostic candidate biomarkers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Five miRNAs as Novel Diagnostic Biomarker Candidates for Primary Nasopharyngeal Carcinoma

Tang¹,

Zhong²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…It is reported that the levels of miR-21 are elevated in NPC tissue 21 and miR-21 increases the IL-10 expression. 22 NPC cells express TLR3, 23 Epstein-Barr virus ligates TLR3 to influence NPC cell activities (Verillaud et al, 2012).…”

Section: Activation Of Tlr3 Upregulates Expression Of Mir-21 In Npc Cmentioning

confidence: 99%

Nasopharyngeal cancer-derived microRNA-21 promotes immune suppressive B cells

Miao

Zhang

et al. 2014

Cell Mol Immunol

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“…Numerous studies have documented that deregulated miRNA expression is strongly linked to the occurrence of various carcinomas (7,8). It has become increasingly apparent that miRNA are of crucial importance for the carcinogenesis and progression of NPC, and therefore they have been highlighted as powerful screening predictors in confirming or monitoring NPC (9)(10)(11)(12)(13)(14)(15). Unfortunately, the clinical utility of miRNA signatures remain unpopular in the clinic.…”

Section: Introductionmentioning

confidence: 99%

“…For example, a previous study has demonstrated that miRNA testing is adequately sensitive and specific for NPC confirmation, with a diagnostic sensitivity and specificity of up to 96% (13). However, some research has reported that miRNA testing achieved an efficacy <60% (10,14,15). Therefore, the present study conducted a comprehensive meta-analysis and aimed to assess the overall diagnostic performance of miRNA as biomarkers for NPC identification.…”

Section: Introductionmentioning

confidence: 99%

Abnormally expressed microRNA as auxiliary biomarkers for nasopharyngeal carcinoma: A meta‑analysis

et al. 2017

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Abstract. Aberrant expression of microRNA (miRNA) has been highlighted as a helpful indicator to aid in nasopharyngeal carcinoma (NPC) diagnosis. The present meta-analysis aimed to validate the efficacy of miRNA as potential biomarkers for NPC detection. Publication searches were conducted on the online PubMed and EMBASE databases from inception to June 2016. A bivariate meta-analysis was performed to generate the diagnostic parameters based on Meta-Disc 1.4 and Stata 12.0 programs. Sensitivity analysis and meta-regression tests were applied to trace heterogeneity sources among eligible studies. A total of six studies comprising 528 patients with NPC and 252 matched controls were enrolled. Results from the present meta-analysis demonstrated that miRNA testing achieved a pooled sensitivity of 0.78 [95% confidence interval (CI), 0.70-0.84] and specificity of 0.79 (95% CI, 0.73-0.84) in confirming NPC, corresponding to an area under the curve (AUC) value of 0.85. Additionally, the pooled diagnostic odds ratio was estimated to be 9.01 (95% CI, 5.62-14.44), along with a positive likelihood ratio of 2.81 (95% CI, 2.19-3.61) and negative likelihood ratio of 0.35 (95% CI, 0.28-0.44). Additionally, the stratified analyses revealed that paralleled testing of miRNA sustained a pooled accuracy superior compared with that of single miRNA testing (sensitivity, 0.88 vs. 0.70; specificity, 0.85 vs. 0.69; AUC, 0.95 vs. 0.75). Testing of miRNA harbors a moderate diagnostic efficacy and is acceptable as an auxiliary biomarker for NPC diagnosis.

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Diagnostic and prognostic value of plasma microRNA deregulation in nasopharyngeal carcinoma

Cited by 62 publications

References 37 publications

Five miRNAs as Novel Diagnostic Biomarker Candidates for Primary Nasopharyngeal Carcinoma

Five miRNAs as Novel Diagnostic Biomarker Candidates for Primary Nasopharyngeal Carcinoma

Nasopharyngeal cancer-derived microRNA-21 promotes immune suppressive B cells

Abnormally expressed microRNA as auxiliary biomarkers for nasopharyngeal carcinoma: A meta‑analysis

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