Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach

Vercelli, Cristina; Peano, Andrea; Piovano, Giulia; Corona, A.; Gambino, Graziana

doi:10.1016/j.mmcr.2021.04.001

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Eles incluem taquipneia ou tosse crônica. Já os sinais neurológicos associados à infecção criptocócica em gatos variam de acordo com a localização das lesões, dentro ou ao redor do sistema nervoso central (PENNISI et al, 2013;VARCELLI et al, 2021) Feline cardiomyopathies are a group of diseases that are related to higher mortality in this species. As they are the most diagnosed heart diseases, they are of extreme clinical importance.…”

Section: Resultsunclassified

“…O tratamento em gatos com anfotericina B é uma possibilidade pois é um medicamento antifúngico de amplo espectro e início de ação rápido e aplicado por via parenteral. Contudo, é um medicamento nefrotóxico e moderadamente eficaz contra criptococose (PENNISI et al, 2013;VARCELLI et al, 2021).…”

Section: Introductionunclassified

“…Tudo isso converge com o que foi relatado pelo autor AndreattiFilho (2006), sobre a formação de massas firmes ou pólipos no tecido subcutâneo, principalmente sobre a cartilagem do plano nasal, levando ao aspecto de "nariz de palhaço".No que concerne aos métodos diagnósticos, o exame PCR pode ser usado como meio altamente sensível e específico de identificar a infecção criptocócica quando outros métodos falham(PENNISI et al, 2013;GREENE, 2015). Neste caso, o diagnóstico foi feito através do histórico clínico, exame físico, juntamente com anamnese minuciosa e cultura fúngica.O tratamento da criptococose em gatos pode ser realizado com anfotericina B, que é um medicamento antifúngico de amplo espectro e início de ação rápido, entretanto, é nefrotóxico e moderadamente eficaz(VARCELLI et al, 2021). Dessa forma, nem sempre é indicado, exceto em casos de doença disseminada com risco de vida(JHONSON et al, 2008).…”

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Leishmaniose Felina: O Que Sabemos Até O Presente Momento?

Júnior¹,

Saraiva²,

Sales³

et al. 2022

Tópicos Em Sanidade De Cães E Gatos, Volume 3

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Section: Resultsunclassified

Section: Introductionunclassified

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Leishmaniose Felina: O Que Sabemos Até O Presente Momento?

Júnior¹,

Saraiva²,

Sales³

et al. 2022

Tópicos Em Sanidade De Cães E Gatos, Volume 3

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Cryptococcosis in domestic and wild animals: A review

et al. 2023

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Cryptococcosis is a fungal disease of public health relevance that affects numerous animal species and humans, causing respiratory and neurological impairment. Hence, we conducted a systematic review that included publications from 1975 to 2021 and covered 132 articles that addressed reports of cryptococcosis in domestic and wild animals, its main clinical manifestations, pathological findings, etiology, diagnosis, and therapeutic protocols. We found that the highest number of reports of cryptococcosis is in domestic species, especially cats. Among the wild and/or exotic animals, koalas and ferrets are the most affected, b eing important carriers of Cryptococcus spp.. Pulmonary and neurological involvement is predominant in all species, although nonspecific clinical manifestations have been reported in various species, making clinical suspicion and diagnosis difficult. The countries with the most reports are Australia, United States, Brazil and Canada, with C. gattii VGI and VGII standing out. The therapies were based on azoles, amphotericin B, and 5-flucytosine, although there is no standard treatment protocol. Although several diagnostic methods have been described, in a significant number of reports the diagnosis was made after necropsy. Professionals are warned about diverse and nonspecific clinical manifestations in different animal species, which underlines the importance of cryptococcosis in the differential diagnosis in clinical practice. Furthermore, it is necessary to encourage the use of laboratory and molecular tools to improve the diagnosis of cryptococcosis. We also emphasize the urgent need for standardized therapeutic protocols to guide veterinary clinicians.

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Antifungal resistance and clinical significance in small animals

Kaya¹,

Dokuzeylül²,

Bakırel³

et al. 2022

Ger. J. Vet. Res.

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In conjunction with the increasing number of immunosuppressive diseases in human and animal populations, fungal diseases have also been rising. Despite the introduction of new antifungal agents in recent years, the incidence of fungal infections continues to increase, and subsequently, the prevalence of resistance to these drugs is remarkably increased, posing significant health concerns. While antifungal drug resistance is of great importance in human medicine, especially against Candida spp., there are few studies about antifungal resistance in veterinary medicine. Indeed, several fungal infections in dogs have been reported, especially in cases of neutropenia associated with the usage of cyclophosphamide or parvoviral enteritis infection. ketoconazole, fluconazole, itraconazole, and terbinafine, the mainly used antifungal drugs in treating dermatomycosis, have been encountered in feline and canine medicine. However, it has been reported that the desired success could not be obtained from the treatments applied in various cases in recent years. This review aimed to emphasize the role of the development of resistance against antifungal agents on treatment failures. In this context, monitoring of antifungal resistance in veterinary clinics and animal facilities by veterinarians and other animal health authorities is recommended

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Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach

Cited by 3 publications

References 17 publications

Leishmaniose Felina: O Que Sabemos Até O Presente Momento?

Leishmaniose Felina: O Que Sabemos Até O Presente Momento?

Cryptococcosis in domestic and wild animals: A review

Antifungal resistance and clinical significance in small animals

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