Diagnostic and Therapeutic Model of Sepsis and Purulent-Inflammatory Diseases

Ostapiuk, Lesia

doi:10.4236/ijcm.2019.1011047

Cited by 13 publications

(15 citation statements)

References 14 publications

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“…During our investigation we were able to determine that a structurally altered albumin would lead to alterations in blood serum fluorescence. Due to the fact that aforementioned method allowed us to determine changes in blood serum within a timespan between 24 -48 hours prior to any clinical signs, we can confirm that it be suc-cessfully implied in sepsis diagnosis [2] [11] and monitoring.…”

Section: Literature Reviewmentioning

confidence: 68%

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A Prognostic Model of the Development of Postpartum Purulent-Inflammatory Diseases

Bulavenko¹,

Ostapiuk²,

Voloshinovskii³

et al. 2020

IJCM

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Background: Currently, postpartum purulent-inflammatory diseases continue to be a prominent issue in medicine. As a result, numerous scientific publications were devoted to finding the solution to this issue. Primarily these solutions included the idea of optimisation of antibiotic-based disease prevention and therapies. However, the early diagnosis and prognosis of these pathologies were unfortunately overlooked. The Aim of the Study: To build a prognostic model of the development of postpartum purulent-inflammatory diseases. Material and Methods: The main focus of our research was establishment of methods of early diagnosis and prognosis of purulent-inflammatory diseases. The main cohort consisted of 170 women diagnosed with purulent-inflammatory diseases while the control cohort was made of 40 women with an uncomplicated course of pregnancy; patient's blood serum was analysed using fluorescence spectroscopy. Additionally, we implied a variety of standardised algorithms used during clinical and laboratory examination of the patients with postpartum endometritis. Results: Fluorescence spectra were studied for 40 women of control group and 170 women of the main group. Based on the data obtained using fluorescence spectroscopy and data from clinical and laboratory examinations (extragenital pathology, gynecology-related diseases, risk of miscarriage, surgery, TORCH-infections, colpitis, labour duration > 12 hrs, labour anomalies, maximum blood serum fluorescence spectrum values, fluorescence spectrum ≤ 0.845, age, number of bed days, fetal distress), we have derived a prognostic model of the development of postpartum purulent-inflammatory diseases. Conclusion: As a result, we derived a prognostic model based on the main

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Section: Literature Reviewmentioning

confidence: 68%

“…Numerous publications were dedicated to this topic, as such they were mostly highlighting optimisation of the existing therapies involving antibiotics. However unfortunately, evaluation of the prognosis and early diagnosis of development of PPPID were severely neglected [2].…”

Section: Introductionmentioning

confidence: 99%

A Prognostic Model of the Development of Postpartum Purulent-Inflammatory Diseases

Bulavenko¹,

Ostapiuk²,

Voloshinovskii³

et al. 2020

IJCM

Self Cite

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“…Further studies of the fluorescence spectra of this patient showed, that bacteremia was not overcome. Although (see Figure 2, curves 3, 4 Note, that for the first time we obtained fundamental results for the fluorescence spectra of a patient with sepsis and studied the dynamics of their changes during her recovery [15] [16]. They became a reference point for our further studies of the fluorescence spectra of BS of patients with purulent-inflammatory diseases and sepsis.…”

Section: Research Resultsmentioning

confidence: 99%

Current Problems of Diagnostics and Treatment of Purulent-Inflammatory Diseases and Sepsis in Medical Practice

Ostapiuk¹,

Voloshinovskii²,

Savchyn³

et al. 2021

IJCM

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Background: Poor treatment of burns can lead to sepsis and even death. Especially promising is the use of the method of fluorescence spectroscopy for its diagnostics. The aim of the research is to create a pathogenetic concept as the basis of a diagnostic and treatment model of purulent-inflammatory diseases and sepsis. Material and methods: The study lasted from 2001 to 2019 and included 4 stages. The experimental base of luminescent research at all stages was the luminescence laboratory of the Department of Experimental Physics of the Ivan Franko National University of Lviv. The study was performed by using optical monochromators MDR-2 and MDR-12. The excitation of the blood serum was performed with light with a wavelength of 280 nm, which corresponds to the glow region of human serum albumin. Results: The main indicators, used for the analysis, were the fluorescence intensity (I F) and the position of the maximum fluorescence band (λ max). The object of the study was samples of the blood serum of patients of the main and control groups. In the case of the presence of endogenous intoxication in the body, albumin binding centers are blocked by the products of bacterial metabolism and therefore such "pathological" albumin is unable to perform its functions, including transport and detoxification. Conclusions: The pathogenetic concept as the basis of the diagnostic and treating model of purulent-inflammatory diseases and sepsis was devised. In particular, the important role of albumin solution infusion in the treatment of the above-mentioned diseases was established.

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“…Albumin is mainly an extracellular protein. 40% of albumin is contained in blood plasma, and 60% in the depo (40% in the skin, 20% in the muscles of the internal organs) 20 .…”

Section: Features Of Changes In Albumin Molecules In Purulent-inflammmentioning

confidence: 99%

Pathogenetic concept as the basis of the diagnostic-treatment model of purulent-inflammatory diseases and sepsis in medical practice

Savchyn¹,

Ostapiuk²,

Voloshinovskii³

2020

Challenges and Achievements of Medical Science and Education

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Diagnostic and Therapeutic Model of Sepsis and Purulent-Inflammatory Diseases

Cited by 13 publications

References 14 publications

A Prognostic Model of the Development of Postpartum Purulent-Inflammatory Diseases

A Prognostic Model of the Development of Postpartum Purulent-Inflammatory Diseases

Current Problems of Diagnostics and Treatment of Purulent-Inflammatory Diseases and Sepsis in Medical Practice

Pathogenetic concept as the basis of the diagnostic-treatment model of purulent-inflammatory diseases and sepsis in medical practice

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