Diagnostic criteria for detection of postinfarction ischemia by quantitative analysis of stepwise dobutamine radionuclide ventriculography

Abstract

Application of appropriate criteria and stepwise quantitative analysis of RNV during dobutamine infusion may increase accuracy in the detection of early postinfarction ischemia.

Evaluation of baseline contractile reserve vs dyssynchrony as a predictor of functional improvement and long term outcome after resynchronization pacing therapy: A radionuclide stress study

“…25 Accuracy and reproducibility of phase analysis and LVEF measurement by ERNA in our laboratory has been previously evaluated and published elsewhere. 22 An example of baseline, LDD and CRT follow-up parametric phase imaging evaluation of ERNA in a dobutamine-responder patient is shown in Figure 1.…”

“…This value has been previously determined by ROC analysis to be the best prognostic cut-off point. 13,25 Clinical end-points during the follow-up period were the major adverse cardiac events (MACE) defined as (1) cardiac death, (2) index re-hospitalization for worsening heart failure or (3) heart transplantation. …”

“…23 Among several methods to unmask viable and recruitable myocardium in the failing heart, low-dose dobutamine (LDD) stress testing in association with either cardiac echocardiographic or radionuclide imaging has gained recognition as an important and accurate modality to predict functional improvement after interventions. [24][25][26] The aim of this study was to prospectively evaluate whether simultaneous assessment of baseline ventricular dyssynchrony, wall motion abnormalities and mCR by ERNA and LDD stress testing may help identifying responders to treatment.…”

Myocardial Contractile Response to Increasing Doses of Dobutamine in Patients with Reperfused Acute Myocardial Infarction by Cardiac Magnetic Resonance Imaging

“…In patients early after AMI, it has been examined by echocardiography [1,2,3,4], radionuclide ventriculography [5, 6] and cardiac magnetic resonance imaging (DCMR) [7,8,9]. Dosing of dobutamine ranged from 5 to 40 µg*kg –1 *min –1 .…”

“…Dosing of dobutamine ranged from 5 to 40 µg*kg –1 *min –1 . A low contractile response of dysfunctional myocardium to dobutamine was attributed to post-infarction ischemia [5] and myocardial necrosis [4], whereas a positive contractile response was interpreted as myocardial stunning [6, 8]. The only study comparing different doses of dobutamine in AMI-patients observed different responses of an echocardiographic myocardial performance index and a wall motion score index at low- and high-dose dobutamine [3].…”