Diagnostic difficulties in spontaneous infarction of a fibroadenoma in an adolescent: Case report

Abstract

Spontaneous infarction is an uncommon complication occurring in fibroadenoma of the breast. Although infarction following fine-needle aspiration has been reported in the literature, to the best of our knowledge this is the first reported case where infarction was encountered on first-time aspiration. It is necessary to distinguish infarcted fibroadenoma from mastitis, duct ectasia, mammary tuberculosis, and carcinoma on cytology smears. Lack of knowledge of this entity may lead to an erroneous diagnosis of inflammatory lesion or carcinoma. We report the first case of cytological and histological findings in spontaneous infarction of fibroadenoma in 13-yr-old female.

Prominant squamous metaplasia with extensive myxoid degeneration and associated ischaemic infarction in fibroadenoma of breast: A diagnostic dilemma

“…This phenomenon has been described in infarcted fibroadenoma in a close proximity to the area of infarction. 5 Presence of extensive ischemic necrosis, very few viable ducts and large areas of squamous metaplastic changes pose a diagnostic difficulty. The differential diagnosis includes underlying breast malignancy, infarcted intraductal papilloma due to presence of large areas of ischemic necrosis and Pleomorphic adenoma due to presence of extensive squmaous metaplasia and stromal hyalinization and myxoid changes.…”

Spontaneous infarction in fibroadenoma of breast: a rare pathological finding in a common pathological entity

“…In case of inflammatory lesion like tuberculous granulomatous mastitis, the differentiation is possible by the presence of epithelioid cell granulomas, multinucleated giant cells, lymphocytes and ZN staining of AFB. [22][23][24][25][26][27][28] Other commonest differential diagnosis like duct ectasia, clinical presentation of subareolar cord like mass helps in the correct diagnosis. 22,26,29 Histopathological examination is the confirmatory investigation for infarction of fibroadenoma which shows abundant areas of ischemic necrosis, haemorrhagic areas with partial or no retain of the architecture of the fibroadenoma.…”

Spontaneous Infarction Of Fibroadenoma Of Breast- A Clinical And Cytohistopathological Study Of Three Cases With Brief Review Of Literature

“…[6][12] Another commonest inflammatory lesion is tuberculous granulomatous mastitis in our country but its differentiation is possible by the presence of epithelioid cell granulomas, multinucleated giant cells, lymphocytes and ZN stain of AFB positivity help in successful diagnosis. [6]- [8], [11]- [14] Other Histopathological examination is the confirmatory investigation for infarction of fibroadenoma which shows abundant areas of ischemic necrosis, haemorrhagic areas with partial or no retain of the architecture of the fibroadenoma. There should be no inflammatory cells or atypical cells.…”

“…In the present study too, two of the cases were diagnosed with subtotal and a single case of total spontaneous infarction of breast was made. Treatment by local excision is adequate for this lesion and under no circumstances should mastectomy be performed without histological proof of malignancy [2]- [4], [6]- [8], [11], [12] IJBR (2015) 6 (02) www.ssjournals.com…”