Generally, production systems as automatic welding process, production of ceramic products, making clothes use automatic control and to evaluate the quality of their production processes, they employ on-line process control. The control system consists of a periodic inspection of one item after every m produced items. The number of non-conformities is monitored in the inspected item and if it exceeds the control limit, then it is decided that the process is out-of-control and the process is stopped for adjustment, otherwise the production continues. The process starts in-control with a fixed non-conformities rate and, after an assignable cause, this rate increases leading the system to operate out of control. The process remains in these conditions until the change is detected and the process adjusted. After adjustment, the process returns to operate in-control. The aim of this paper is to present an economic approach to monitor the rate of non-conformities in a production by on-line process control. To design such type of process, an average cost per item produced is achieved through the properties of an ergodic Markov chain and the two required parameters: the inspection interval and the upper control limit are obtained by minimizing the average cost per produced item. A numerical example illustrates the proposal. It was identified the most important factors which result a considerable impact on the average cost per item: the probability of a shift in the parameter of Poisson distribution; cost to send non-conforming items to the customers; the in-control non-conformity rate; the specification limit and the cost of adjustment.