Diagnostic et traitement des tumeurs de vessie par thérapie photodynamique

Guillemin, François; Cosserat-Gérardin, Isabelle; Notter, Dominique; Vigneron, C.

doi:10.1016/s0369-8114(01)00223-1

Cited by 9 publications

(4 citation statements)

References 34 publications

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“…Among them, in 1994, Morgan et al described the coupling of AlPc(SO 2 Cl) 4 to antibody E7 (MAb E7, IgM subclass) which recognized an antigenic determinant and compared the activities of the covalently conjugated MAb-Pc, using a sulfonamide linker, and of the liposomal MAb-Pc for selective photoimmunotherapy of human bladder carcinoma [70]. They found that covalent conjugation of AlPc(SO 2 Cl) 4 with tumor-specific antibody E7 widely increased phototoxicity compared to free AlPc(SO 2 Cl) 4 . Moreover, phototoxicity on human bladder carcinoma cell line 647V expressing the antigenic determinant was dose-dependent for both covalent and liposomal conjugates: at equimolar Pc doses, absolute toxicity was similar for both conjugates, but at equimolar antibody doses, the liposomal conjugate was 13-fold more effective.…”

Section: Adenoviruses and Adenoviral Proteinsmentioning

confidence: 99%

“…In the same time, Vrouenraets et al described an original and efficient four-steps synthetic route for the covalent coupling of AlPcS 4 to MAbs U36, E48 and 425 via the tetraglycine derivative AlPc(SO 2 N gly ) 4 [73]. Briefly, AlPc(SO 2 Cl) 4 , prepared by chlorination of AlPc(SO 3 H) 4 , was converted to the tetraglycine derivative AlPc(SO 2 N gly ) 4 , using a large excess of glycine and benzotriazole (BTA), followed by an esterification of the carboxylic group using a large excess of 2,3,5,6-tetrafluorophenol (TFP) at pH 5.8. Selective hydrolysis and conjugation to MAbs were achieved in a one-pot procedure…”

Section: Allmentioning

confidence: 99%

“…PDT is being developed as a treatment for cancer of the oesophagus [1], bronchi [2,3] and bladder [4,5], as well as for other non-oncological applications, such as the treatment of age-related macular degeneration [6]. PDT is also used as a successful non-invasive therapeutic modality for treating cutaneous neoplasm [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Schematic representation of the synthesis of AlPc(SO 2 NCH 2 COOH)4 via AlPc(SO 2 Cl)4 , its esterification and conjugaison to a I-labeledMab. .…”

mentioning

confidence: 99%

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Phthalocyanines Covalently Bound to Biomolecules for a Targeted Photodynamic Therapy

Taquet¹,

Frochot²,

Manneville³

et al. 2007

CMC

159

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Photodynamic therapy (PDT) is a relatively new cytotoxic treatment, predominantly used in anticancer approaches, that depends on the retention of photosensitizers in tumor and their activation after light exposure. This technology is based on the light excitation of a photosensitizer which induces very localized oxidative damages within the cells by formation of highly reactive oxygen species, the most important being singlet oxygen. Many photo-activable molecules have been synthesized such as porphyrins, chlorins and more recently phthalocyanines which present a strong light absorption at wavelengths around 670 nm and are therefore well-adapted to the optical window required for PDT application. However, the lack of selective accumulation of these photo-activable molecules within tumor tissue is a major problem in PDT, and one research area of importance is developing targeted photosensitizers. Indeed, targeted photodynamic therapy offers the advantage to enhance photodynamic efficiency by directly targeting diseased cells or tissues. Many attempts have been made to either increase the uptake of the dye by the target cells and tissues or to improve subcellular localization so as to deliver the dye to photosensitive sites within the cells. The aim of this review is to present the actual state of the development of phthalocyanines covalently conjugated with biomolecules that possess a marked selectivity towards cancer cells; for some of them their photophysical properties and photodynamic activity will be presented.

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Section: Adenoviruses and Adenoviral Proteinsmentioning

confidence: 99%

Section: Allmentioning

confidence: 99%