Diagnostic Fine-Needle Aspiration Biopsy for Iris Melanoma

Gokhale, Rahul; Biscotti, Charles V.; Singh, Arun D.

doi:10.1097/apo.0000000000000083

Cited by 11 publications

(10 citation statements)

References 23 publications

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“…Early diagnosis of a tumor that is presenting a diffused growth pattern could mainly be made after a biopsy. Iris lesions can be biopsied in various ways: iridectomy with total excision of the lesion (excisional biopsy), fine needle aspiration biopsy (FNAB) [12] or small gauge vitrector-assisted biopsy [13]. For the pathologist the key issue is to identify such features as cytoplasmic melanin and spindle cell presence [12].…”

Section: Discussionmentioning

confidence: 99%

“…Iris lesions can be biopsied in various ways: iridectomy with total excision of the lesion (excisional biopsy), fine needle aspiration biopsy (FNAB) [12] or small gauge vitrector-assisted biopsy [13]. For the pathologist the key issue is to identify such features as cytoplasmic melanin and spindle cell presence [12]. Immunohistochemistry both for epithelial and melanoma markers such as S100 and HMB45 is often useful when diagnostic doubts occur, especially in amelanotic tumors with the predominance of epithelioid cells [12].…”

Section: Discussionmentioning

confidence: 99%

“…For the pathologist the key issue is to identify such features as cytoplasmic melanin and spindle cell presence [12]. Immunohistochemistry both for epithelial and melanoma markers such as S100 and HMB45 is often useful when diagnostic doubts occur, especially in amelanotic tumors with the predominance of epithelioid cells [12].…”

Section: Discussionmentioning

confidence: 99%

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Iris melanoma with ciliary body infiltration presenting as a presumed chronic unilateral inflammatory glaucoma. The challenges of iris tumor biopsy assessment

Stodolska-Nowak¹,

Adamski²,

Brązert³

et al. 2021

pjp

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Uveal melanoma is the most common primary malignancy of the eye in adults. It may involve the choroid and ciliary body, and in only 2-3% of cases it involves the iris. We present a case of a 56-year-old patient with a 6-year history of unilateral, inflammatory, refractory glaucoma of the right eye. Due to acquired heterochromia and heterogeneous thickness of the iris, iris melanoma was suspected, but the incisional biopsy did not confirm the diagnosis. In the next months, the lesion enlarged and the eye globe was enucleated. Histopathological examination revealed an iridociliary melanoma with annular growth pattern.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Iris melanoma with ciliary body infiltration presenting as a presumed chronic unilateral inflammatory glaucoma. The challenges of iris tumor biopsy assessment

Stodolska-Nowak¹,

Adamski²,

Brązert³

et al. 2021

pjp

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“…(4) The incidence of iris melanoma varies between 0.2 and 0.9 per million persons. (6) The incidence of iris melanoma has been growing in recent decades, according to the literature, which is most likely due to the impact of solar radiation. (7) (8) The prevalence appears to be unaffected by geographic location.…”

Section: Introductionmentioning

confidence: 99%

Iris Melanoma: Genetic Pathway, Staging, Histopathology, Clinical Features, Diagnostic Imaging, Treatment and Management

Rehmani

Charan

Rani

2022

Int J Sci Healthcare Res

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Introduction- Iris melanomas mainly grow in the anterior chamber or along the iris surface, and by local extension; they commonly invade the anterior chamber angle and anterior ciliary body. Iris melanomas account for 2–3% of all uveal melanomas, with the diffuse variety accounting for about 10% of all iris melanomas. Methodology-A systematic review is a technical tool that basically describes a more or less systematic way of collecting and synthesizing past research by integrating findings and perspectives from a variety of empirical findings. In this study, authors conducted a systematic assessment of 51 research articles on the subject of "Iris Melanoma" in order to examine and compare the various approaches and outcomes. This comprehensive review summarizes all 51 research articles in the most accessible manner to discuss the Genetic pathway, Staging, Histopathology, Clinical features, Diagnostic Imaging, Treatment, and Management. Results-Iris melanomas are discovered early and treated fast because they are apparent when they are little. As a result, patients with this tumor had a better prognosis than those with posterior uvea tumors. Conclusion- Radiotherapy or surgical resection are usually used in this situation. A combination of radiotherapy and surgery may be employed in some circumstances. Conservative treatment is an excellent option for enucleation since it provides for effective tumor control locally. Keywords:melanoma, Diagnosis, Management, Stages, Eye-care.

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“…McLaughlin et al found the incidence of uveal melanomas to be about six cases per million people (6.8 for men and 5.3 for women) [9]. For iris melanoma, the incidence varies between 0.2 and 0.9 per million people [10]. The lowest value was found in Finland [11,12] and the highest was found in New Zealand [2,13].…”

Section: Introduction and General Overviewmentioning

confidence: 99%

Iris Melanoma: Management and Prognosis

et al. 2020

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Iris melanomas represent 2–5% of uveal melanomas. Iris melanomas vary in their size, shape, degree of pigmentation and clinical behavior. The main local clinical complications of iris melanomas are tumor vascularization, ectropion uvea, pupillary distortion, pigment dispersion, sector cataract, chronic uveitis, hyphema and glaucoma with irreversible optic nerve damage. The most effective treatment for iris nevus and melanoma remains debatable; treatment modalities have been proposed depending on the local status as well as the age and general condition of the patient. A melanocytic iris nevus is usually observed until documented progression is identified. In this case, radiotherapy or surgical resection is generally performed. Cataract, glaucoma and limbal stem cell deficiency are usually secondary to radiotherapy, while incomplete tumor excisions, which could lead to recurrence, hemorrhage, vitreous loss, dislocated lens, iridocyclitis, macular edema, retinal detachment, glaucoma and cataract, are related to surgical resection. In some cases, a combination of radiotherapy and surgery is used. Conservative treatment is an efficient alternative to enucleation and allows good local tumor control.

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Diagnostic Fine-Needle Aspiration Biopsy for Iris Melanoma

Abstract: Although indicated only in minority of cases, it is important to consider FNAB for the diagnosis and management of iris lesions.

Cited by 11 publications

References 23 publications

Iris melanoma with ciliary body infiltration presenting as a presumed chronic unilateral inflammatory glaucoma. The challenges of iris tumor biopsy assessment

Iris melanoma with ciliary body infiltration presenting as a presumed chronic unilateral inflammatory glaucoma. The challenges of iris tumor biopsy assessment

Iris Melanoma: Genetic Pathway, Staging, Histopathology, Clinical Features, Diagnostic Imaging, Treatment and Management

Iris Melanoma: Management and Prognosis

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