Diagnostic Groups and Depressed Mood as Predictors of 22-Month Mortality in Medical Inpatients

Herrmann, Christoph S.; Brand-Driehorst, Sigrid; Kaminsky, Britta; Leibing, Eric; Schmitz, Hermann; Rüger, Ulrich

doi:10.1097/00006842-199809000-00011

Cited by 127 publications

(75 citation statements)

References 33 publications

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“…High depression and anxiety values have both been shown to predict subsequent mortality [3,7]. However, in some cases, symptoms of depression but not anxiety in multivariate models predicted mortality [5,6], and in some, neither depression nor anxiety symptoms were found to predict mortality in MI patients [9].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the question arises whether depression following MI is a risk factor for cardiovascular morbidity and mortality. Although the number of positive studies in this field has been growing steadily, the discrepancies have continued since the publication of a few negative results [3][4][5][6][7][8][9]. Scant studies have Seyed Hamzeh Hosseini et al, Anxiety and depression as predictors of MI mortality reported longer-term mortality data in MI patients; whereas one has found an association between an in-hospital depression and mortality 5 years later [10], the other has observed no association at 3-year follow-up [11].…”

Section: Introductionmentioning

confidence: 99%

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Levels of anxiety and depression as predictors of mortality following myocardial infarction: A 5-year follow-up

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Levels of anxiety and depression as predictors of mortality following myocardial infarction: A 5-year follow-up

et al. 2014

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“…Also, depressive symptoms that are not sufficient in magnitude to meet the criteria for major depression occur at least as commonly among cardiac patients. 2,3 Recent epidemiological studies evaluating the relationship between depression and CAD among healthy [3][4][5][6][7][8][9][10][11] and CAD [12][13][14][15][16][17][18][19] populations consistently demonstrate a significant prospective relationship between the occurrence of major depression episodes and the incidence of cardiac events (Table 1). Two additional findings are notable.…”

Section: Depression and Related Syndromesmentioning

confidence: 99%

“…The epidemiological investigation of anxiety disorders among CAD patients has also been quite sparse. Because 4 small studies have each noted a relationship between anxiety and a constellation of hard and soft cardiac events among CAD patients (Table 2), 17,18,47,48 more large-scale epidemiological studies among CAD patients now appear to be warranted.…”

Section: Anxiety Syndromesmentioning

confidence: 99%

Impact of Psychological Factors on the Pathogenesis of Cardiovascular Disease and Implications for Therapy

1999

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Abstract-Recent studies provide clear and convincing evidence that psychosocial factors contribute significantly to the pathogenesis and expression of coronary artery disease (CAD). This evidence is composed largely of data relating CAD risk to 5 specific psychosocial domains: (1) depression, (2) anxiety, (3) personality factors and character traits, (4) social isolation, and (5) chronic life stress. Pathophysiological mechanisms underlying the relationship between these entities and CAD can be divided into behavioral mechanisms, whereby psychosocial conditions contribute to a higher frequency of adverse health behaviors, such as poor diet and smoking, and direct pathophysiological mechanisms, such as neuroendocrine and platelet activation. An extensive body of evidence from animal models (especially the cynomolgus monkey, Macaca fascicularis) reveals that chronic psychosocial stress can lead, probably via a mechanism involving excessive sympathetic nervous system activation, to exacerbation of coronary artery atherosclerosis as well as to transient endothelial dysfunction and even necrosis. Evidence from monkeys also indicates that psychosocial stress reliably induces ovarian dysfunction, hypercortisolemia, and excessive adrenergic activation in premenopausal females, leading to accelerated atherosclerosis.Also reviewed are data relating CAD to acute stress and individual differences in sympathetic nervous system responsivity. New technologies and research from animal models demonstrate that acute stress triggers myocardial ischemia, promotes arrhythmogenesis, stimulates platelet function, and increases blood viscosity through hemoconcentration. In the presence of underlying atherosclerosis (eg, in CAD patients), acute stress also causes coronary vasoconstriction. Recent data indicate that the foregoing effects result, at least in part, from the endothelial dysfunction and injury induced by acute stress. Hyperresponsivity of the sympathetic nervous system, manifested by exaggerated heart rate and blood pressure responses to psychological stimuli, is an intrinsic characteristic among some individuals. Current data link sympathetic nervous system hyperresponsivity to accelerated development of carotid atherosclerosis in human subjects and to exacerbated coronary and carotid atherosclerosis in monkeys.Thus far, intervention trials designed to reduce psychosocial stress have been limited in size and number. Specific suggestions to improve the assessment of behavioral interventions include more complete delineation of the physiological mechanisms by which such interventions might work; increased use of new, more convenient "alternative" end points for behavioral intervention trials; development of specifically targeted behavioral interventions (based on profiling of patient factors); and evaluation of previously developed models of predicting behavioral change. The importance of maximizing the efficacy of behavioral interventions is underscored by the recognition that psychosocial stresses tend to cluster together. ...

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“…Also, an association between depressed mood and sleep disturbance has been reported based on a cohort of 3880 patients in Germany [3]. Moreover, depressed mood has been proposed as an independent risk factor for 22-month mortality in physically ill patients [4].…”

Section: Introductionmentioning

confidence: 96%

Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: results from the CRESCEND study

Park

Kim

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objective: We examined the prevalence and clinical characteristics of patients with major depressive disorder (MDD) without depressed mood, using data from the Clinical Research Center for Depression (CRESCEND) study in South Korea. Methods: Using analysis of covariance for continuous variables and binary logistic regression analysis for discrete variables, the clinical characteristics of MDD patients with and without depressed mood were compared after controlling for the potential effects of gender. To represent the extent of group differences, we computed Cohen's d statistics. Results: Of 1009 MDD patients, only 2.2% were without depressed mood. Compared with those with depressed mood, these patients were characterized by a significantly lower rate of current suicidal ideation (adjust odds ratio = 5.

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Diagnostic Groups and Depressed Mood as Predictors of 22-Month Mortality in Medical Inpatients

Abstract: Depressed mood is an independent risk factor for all-cause mortality in medical inpatients. Identifying patients at risk does not require formal psychiatric diagnoses, but can be achieved by means of a short, routinely administered self-rating questionnaire.

Cited by 127 publications

References 33 publications

Levels of anxiety and depression as predictors of mortality following myocardial infarction: A 5-year follow-up

Levels of anxiety and depression as predictors of mortality following myocardial infarction: A 5-year follow-up

Impact of Psychological Factors on the Pathogenesis of Cardiovascular Disease and Implications for Therapy

Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: results from the CRESCEND study

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