Diagnostic impact of echo planar diffusion-weighted magnetic resonance imaging (DWI) in musculoskeletal neoplastic masses using apparent diffusion coefficient (ADC) mapping as a quantitative assessment tool

Khedr, Sherif; Hassaan, Mohamed A.; Abdelrazek, Naglaa Mohamed; Sakr, Amr

doi:10.1016/j.ejrnm.2012.03.003

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…Los pacientes que presentaron metástasis fueron 24, con una media de CDA de 0,88 (DE: ± 0,14) × 10 −3 mm 2 /s, encontrando similitud con la literatura 22,24,25,[34][35][36] .…”

Section: Discussionunclassified

Diferenciación de la patología tumoral musculoesquelética benigna y maligna utilizando la técnica de difusión con resonancia magnética

Re¹,

Cabral²,

Zenklusen³

et al. 2023

RAR

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Introducción: La imagen ponderada en difusión es una técnica de imagen funcional que aporta información complementaria a las secuencias convencionales de resonancia magnética. El coeficiente de difusión aparente (CDA) se valora junto con la secuencia de difusión, calculando el logaritmo negativo de la proporción de intensidades de dos conjuntos de imágenes, lo que permite el análisis cuantitativo de la restricción a la difusión. Objetivo: Determinar si existe una diferencia significativa entre los valores de CDA de las lesiones musculoesqueléticas benignas y malignas, correlacionando los resultados con los hallazgos histológicos. Método: Estudio prospectivo, observacional y descriptivo. Se incluyeron en el trabajo pacientes con sospecha de lesiones tumorales del sistema musculoesquelético de cualquier edad y sexo, sin antecedentes de radioterapia previa o cirugía, evaluados con resonancia magnética y con posterior biopsia o cirugía. Resultados: Se incluyeron 170 pacientes, de los cuales 80 (44 benignos) eran hombres y 90 (43 benignos) eran mujeres. El total fue de 87 lesiones benignas y 83 lesiones malignas, con una media de CDA de 1,44 ± 0,55 × 10 −3 mm 2 /s y de 0,96 ± 0,4 × 10 −3 mm 2 /s, respectivamente, con una diferencia estadísticamente significativa (p < 0,001; 6,335; 168). Conclusiones: Los valores de difusión, y particularmente el CDA, han aportado información adicional en la caracterización de los tumores benignos y malignos, con diferencia significativa, estableciendo valores altos de CDA para los tumores benignos.

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“…Los pacientes que presentaron metástasis fueron 24, con una media de CDA de 0,88 (DE: ± 0,14) × 10 −3 mm 2 /s, encontrando similitud con la literatura 22,24,25,[34][35][36] .…”

Section: Discussionunclassified

Diferenciación de la patología tumoral musculoesquelética benigna y maligna utilizando la técnica de difusión con resonancia magnética

Re¹,

Cabral²,

Zenklusen³

et al. 2023

RAR

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“…Quantitative analysis of ADC maps correlated with type, side and time of injury indicated that ADC values were statistically significant when differentiating type of AT pathology; ADC values showed that an increased ADC is evident in patients presenting with complete, partial and, micro tears within the AT (1.68 × 10 -3 , 1.546 × 10 -3 and 1.224 × 10 -3 ) compared to inflammation, thickness or tendinopathy of the AT (0.151 × 10 -3 , 0.343 × 10 -3 and 0.174 × 10 -3 ). Also, it was seen that when the tendon has multiple pathologies ADC is higher; for example, complete and partial tears have a greater effect on the measured ADC values (thickening + tear: 1.88 × 10 -3 ) compared to a combination of lower grade pathologies (tendinopathy + thickening: 0.351 × 10 -3 ), this may be attributed to the increased diffusion of water molecules associated with high-grade pathology compared to lower grade pathology [22]. No significance was found in relation to side (right or left), or the time at which patients were scanned following the initial occurrence of their AT pathology, these findings were attributed to the decline in the number of patients thought out the follows up, and the inconsistencies in the degree to which certain pathologies healed and/or progressed over time.…”

Section: Limitationsmentioning

confidence: 97%

“…There have been few studies evaluating diffusionweighted MR imaging of ligaments, cartilage or musculoskeletal tissues with a similar collagen fibre based structure [22,24]. Body DWI offers good sensitivity to detect cellular-dense lesions and has several applications in oncological imaging [10].…”

Section: Role Of the Funding Sourcementioning

confidence: 99%

Diffusion Weighted Magnetic Resonance Imaging of the Achilles tendon and Related Pathology: Qualitative & Quantitative Investigation

Al¹,

Allison²,

Stephen³

et al. 2019

Int J Foot Ankle

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Background: Diffusion-weighted imaging (DWI) is an MRI technique that has shown to be a very promising in facilitating the differentiation of subtle pathological changes within different tissue. However, to date, a conclusive physical basis for the signal contrast on DWI of the Achilles tendon (AT) is yet to be available in literature. The purpose of this work is to evaluate the diagnostic impact of echo planar DWI in distinguishing normal and abnormal AT using ADC mapping as a qualitative and quantitative assessment tool.

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“…3 The modality of choice for tumors and tumor-like conditions is often MRI, owing to its excellent soft tissue contrast, its sensitivity to bone marrow and soft tissue edema, and its multiplanar imaging. 1,4 It is key for diagnosing, staging, preoperative work-up, and follow-up of patients with benign and malignant soft tissue neoplasms. [3][4][5] Furthermore, it provides detailed tissue characterization and aids in the staging of bone lesions.…”

Section: Introductionmentioning

confidence: 99%

“… 1 4 It is key for diagnosing, staging, preoperative work-up, and follow-up of patients with benign and malignant soft tissue neoplasms. 3 4 5 Furthermore, it provides detailed tissue characterization and aids in the staging of bone lesions. 2 MRI is also useful in the evaluation of trauma, 2 6 infection, and neuromuscular disease.…”

Section: Introductionmentioning

confidence: 99%

The Use of Gadolinium in Musculoskeletal MRI—Time to Rethink?

Elawad

Shah

Davies

et al. 2021

Indian J Radiol Imaging

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Magnetic resonance imaging has continued to evolve over the recent decades, in part, due to the evolution of gadolinium-based contrast agents and their use. These were initially thought to have a relatively low-risk profile. However, there is mounting evidence that trace amounts of gadolinium are retained within the body. To ascertain the current use of gadolinium in medical practice, we performed a survey of musculoskeletal radiologists, within the United Kingdom, Europe and India. The survey demonstrated varied practices amongst all radiologists with relatively indiscriminate use of gadolinium. In this review, we discuss the current evidence for and against the use of gadolinium in musculoskeletal magnetic resonance imaging.

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Diagnostic impact of echo planar diffusion-weighted magnetic resonance imaging (DWI) in musculoskeletal neoplastic masses using apparent diffusion coefficient (ADC) mapping as a quantitative assessment tool

Cited by 9 publications

References 18 publications

Diferenciación de la patología tumoral musculoesquelética benigna y maligna utilizando la técnica de difusión con resonancia magnética

Diferenciación de la patología tumoral musculoesquelética benigna y maligna utilizando la técnica de difusión con resonancia magnética

Diffusion Weighted Magnetic Resonance Imaging of the Achilles tendon and Related Pathology: Qualitative & Quantitative Investigation

The Use of Gadolinium in Musculoskeletal MRI—Time to Rethink?

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