Diagnostic Management of Pancreatic Cancer

Dabizzi, Emanuele; Assef, Maurício Saab; Raimondo, Massimo

doi:10.3390/cancers3010494

Cited by 11 publications

(7 citation statements)

References 54 publications

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“…This phenomenon was observed in other studies on abdominal ultrasonography. Dabizzi et al, 9 showed that the sensitivity of ultrasonography in detecting pancreatic tumors can reach 95%, which is consistent with the results of our study. In addition, Michl et al 10 demonstrated that ultrasonography may have similar sensitivity to that of CT for detecting small lesions (<2 cm, cT1), especially when advanced imaging techniques are used.…”

Section: Discussion Diagnostic Accuracy For Establishing T Categoriessupporting

confidence: 93%

“…33 Other studies reported a higher accuracy of abdominal ultrasonography, reaching 80% to 96% when the color Doppler mode was used. 7,9,31 Minniti et al 21 reported the accuracy of ultrasonography to be 81.4%, which was lower than that of CT (86%). The advancement in surgical techniques has enabled to use resection for more advanced pancreatic tumors.…”

Section: Discussion Diagnostic Accuracy For Establishing T Categoriesmentioning

confidence: 98%

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Role of abdominal ultrasonography in clinical staging of pancreatic carcinoma: a tertiary center experience

Kulig¹,

Pach²,

Kulig³

2014

Polish Archives of Internal Medicine

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INTROduCTIONPancreatic carcinoma remains one of the leading causes of cancer -related deaths in the world. In the years from 2000 to 2009, the incidence rate in the United States increased by 0.9% per year and the death rate increased by 0.5% per year.1 The overall 5 -year survival rate reported worldwide does not exceed 5%. Even for patients with a tumor that has been surgically removed, the 5 -year survival is only about 20% to 25%. In 2009 in Poland, pancreatic cancer was the second cause of death due to malignant gastrointestinal neoplasms in women and the third one in men. 2Over the years, various radiological imaging modalities have been used for the diagnosis and staging of pancreatic cancer, including abdominal ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI), laparoscopy, and endoscopic ultrasonography.Currently, thin -section, contrast -enhanced multi -detector CT is regarded as the investigation of choice in patients with pancreatic cancer. The sensitivity of CT in detecting pancreatic cancer is between 75% and 100% with specificity of 70% to 100%.3,4 MRI has been proved to be effective in the diagnosis and staging of pancreatic cancers; therefore, it should be used in centers where these facilities are readily available. Positron emission tomography-CT is a useful complementary investigation to exclude metastases outside the abdomen. Staging laparoscopy and laparoscopic ultrasonography are important in the restaging of locally advanced lesions after neoadjuvant therapy.3 However, in view of wide availability, noninvasiveness, low cost, and relatively high diagnostic accuracy, abdominal ultrasonography is routinely used as the first -line diagnostic modality in pancreatic cancer, and its sensitivity ORIGINAL ARTICLERole of abdominal ultrasonography in clinical staging of pancreatic carcinoma: a tertiary center experience Piotr Kulig, Radosław Pach, Jan Kulig 1st Department of General Surgery, Jagiellonian University Medical College, Kraków, PolandCorrespondence to: dr n. med. Radoslaw Pach, I Katedra Chirurgii Ogólnej, Uniwersytet Jagielloński, Collegium Medicum, ul. Kopernika 40, Poland, AbsTRACTINTROduCTION Various imaging modalities are used for the diagnosis and staging of pancreatic cancer. Abdominal ultrasonography is the most widely available method and usually the first -line diagnostic tool used in patients with suspicion of pancreatic carcinoma.

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Section: Discussion Diagnostic Accuracy For Establishing T Categoriessupporting

confidence: 93%

Section: Discussion Diagnostic Accuracy For Establishing T Categoriesmentioning

confidence: 98%

Role of abdominal ultrasonography in clinical staging of pancreatic carcinoma: a tertiary center experience

Kulig¹,

Pach²,

Kulig³

2014

Polish Archives of Internal Medicine

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“…The sensitivity of US is ~ 95% if the lesion is more than 3 cm. With CT, which is the method of choice for evaluating patients with symptoms that are suggestive of the disease, lesions larger than 1.5 cm are detected at 100% but smaller lesions have a sensitivity of 77% and a specificity of 100% (27). The high soft tissue contrast of MRI provides an attractive option in staging PDAC (27).…”

Section: Discussionmentioning

confidence: 99%

“…With CT, which is the method of choice for evaluating patients with symptoms that are suggestive of the disease, lesions larger than 1.5 cm are detected at 100% but smaller lesions have a sensitivity of 77% and a specificity of 100% (27). The high soft tissue contrast of MRI provides an attractive option in staging PDAC (27). The desmoplastic stroma of PDAC prevents the delivery of contrast agents resulting in an absence of hyperintensity in the tumor compared to normal parenchyma that is useful in guiding resection and staging (27).…”

Section: Discussionmentioning

confidence: 99%

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Metabolic Imaging of Pancreatic Ductal Adenocarcinoma Detects Altered Choline Metabolism

Penet

Shah

Bharti

et al. 2015

Clinical Cancer Research

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Purpose Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal disease that develops relatively symptom-free and is therefore advanced at the time of diagnosis. The absence of early symptoms and effective treatments has created a critical need for identifying and developing new noninvasive biomarkers and therapeutic targets. Experimental Design We investigated the metabolism of a panel of PDAC cell lines in culture and noninvasively in vivo with 1H magnetic resonance spectroscopic imaging (MRSI) to identify noninvasive biomarkers and uncover potential metabolic targets. Results We observed elevated choline-containing compounds in the PDAC cell lines and tumors. These elevated choline-containing compounds were easily detected by increased total choline (tCho) in vivo, in spectroscopic images obtained from tumors. Principal component analysis of the spectral data identified additional differences in metabolites between HPNE and neoplastic PDAC cells. Molecular characterization revealed overexpression of choline kinase (Chk)-α, choline transporter 1 (CHT1), and choline transporter-like protein 1 (CTL1) in the PDAC cell lines and tumors. Conclusions Collectively, these data identify new metabolic characteristics of PDAC and reveal potential metabolic targets. Total choline detected with 1H MRSI may provide an intrinsic, imaging-probe independent biomarker to complement existing techniques in detecting PDAC. The expression of Chk-α, CHT1, and CTL1 may provide additional molecular markers in aspirated cytological samples.

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Pancreatic Cancer

Pek¹

2019

Principles of Specialty Nursing

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Diagnostic Management of Pancreatic Cancer

Cited by 11 publications

References 54 publications

Role of abdominal ultrasonography in clinical staging of pancreatic carcinoma: a tertiary center experience

Role of abdominal ultrasonography in clinical staging of pancreatic carcinoma: a tertiary center experience

Metabolic Imaging of Pancreatic Ductal Adenocarcinoma Detects Altered Choline Metabolism

Pancreatic Cancer

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