Diagnostic performance of [18F]-FDG PET/MR in evaluating colorectal cancer: a systematic review and meta-analysis

Mirshahvalad, Seyed Ali; Hinzpeter, Ricarda; Kohan, Andrés; Anconina, Reut; Kulanthaivelu, Roshini; Ortega, Claudia; Metser, Ur; Veit-Haibach, Patrick

doi:10.1007/s00259-022-05871-0

Cited by 18 publications

(14 citation statements)

References 60 publications

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“…MRI is mainly used for checking a suspicion of relapses, especially for rectal tumors and suspected hepatic metastases. PET/CT is indicated to evaluate the whole body and check distant metastases [ 29 ].…”

Section: Preoperative Imagistic Assessment-particular Issuesmentioning

confidence: 99%

“…Afterward, the LN stations map that was published in the 3rd edition of the Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma can be used by the radiologist to encircle the imagistically identified LN groups ( Figure 1 ). This adapted map is meant to assure the surgical removal of all suspect LNs, thus avoiding pathological sub-staging [ 29 , 30 ]. Based on such maps, new valid evidence-based results will help future staging updates [ 31 , 32 , 33 ].…”

Section: Preoperative Imagistic Assessment-particular Issuesmentioning

confidence: 99%

“…Based on such maps, new valid evidence-based results will help future staging updates [ 31 , 32 , 33 ]. CT provides a lower performance, compared with MRI, for evaluation of the depth of infiltration, especially for low-T stages [ 29 ].…”

Section: Preoperative Imagistic Assessment-particular Issuesmentioning

confidence: 99%

“…For rectal cancers, pelvic MRI is the gold standard imaging way for evaluation of primary tumors and local recurrences, even for cases with a large post-radiotherapy fibrotic scar. The risk of local relapse can be predicted based on the distance between the tumor and circumferential resection margins, combined with the presence or absence of extramural invasion [ 29 ].…”

Section: Preoperative Imagistic Assessment-particular Issuesmentioning

confidence: 99%

“…Due to limited spatial resolution, the preoperative T stage cannot be properly performed with PET/CT. High specificity, but low sensitivity was also proved for N staging [ 29 ].…”

Section: Preoperative Imagistic Assessment-particular Issuesmentioning

confidence: 99%

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From Dukes-MAC Staging System to Molecular Classification: Evolving Concepts in Colorectal Cancer

Banias

Jung

Chiciudean

et al. 2022

IJMS

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This historical review aimed to summarize the main changes that colorectal carcinoma (CRC) staging systems suffered over time, starting from the creation of the classical Duke’s classification, modified Astler–Coller staging, internationally used TNM (T—primary tumor, N—regional lymph nodes’ status, M—distant metastases) staging system, and ending with molecular classifications and epithelial–mesenchymal transition (EMT) concept. Besides currently used staging parameters, this paper briefly presents the author’s contribution in creating an immunohistochemical (IHC)-based molecular classification of CRC. It refers to the identification of three molecular groups of CRCs (epithelial, mesenchymal and hybrid) based on the IHC markers E-cadherin, β-catenin, maspin, and vimentin. Maspin is a novel IHC antibody helpful for tumor budding assessment, which role depends on its subcellular localization (cytoplasm vs. nuclei). The long road of updating the staging criteria for CRC has not come to an end. The newest prognostic biomarkers, aimed to be included in the molecular classifications, exert predictive roles, and become more and more important for targeted therapy decisions.

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Section: Preoperative Imagistic Assessment-particular Issuesmentioning

confidence: 99%

Section: Preoperative Imagistic Assessment-particular Issuesmentioning

confidence: 99%

Section: Preoperative Imagistic Assessment-particular Issuesmentioning

confidence: 99%

Section: Preoperative Imagistic Assessment-particular Issuesmentioning

confidence: 99%

“…Due to limited spatial resolution, the preoperative T stage cannot be properly performed with PET/CT. High specificity, but low sensitivity was also proved for N staging [ 29 ].…”

Section: Preoperative Imagistic Assessment-particular Issuesmentioning

confidence: 99%

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From Dukes-MAC Staging System to Molecular Classification: Evolving Concepts in Colorectal Cancer

Banias

Jung

Chiciudean

et al. 2022

IJMS

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Personalised PET imaging in oncology: an umbrella review of meta-analyses to guide the appropriate radiopharmaceutical choice and indication

Kirienko,

Gelardi,

Fiz

et al. 2024

Eur J Nucl Med Mol Imaging

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Purpose For several years, oncological positron emission tomography (PET) has developed beyond 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG). This umbrella review of meta-analyses aims to provide up-to-date, comprehensive, high-level evidence to support appropriate referral for a specific radiopharmaceutical PET/computed tomography (CT) or PET/magnetic resonance (MR) in the diagnosis and staging of solid cancers other than brain malignancies. Methods We performed a systematic literature search on the PubMed/MEDLINE and EMBASE databases for meta-analyses assessing the accuracy of PET/CT and/or PET/MRI with [18F]FDG, somatostatin- receptor-targeting 68Ga-DOTA-peptides, 18F-labelled dihydroxyphenylalanine ([18F]DOPA), prostate-specific membrane antigen (PSMA)-targeted radioligands, and fibroblast activation protein inhibitors (FAPI) in the diagnosis/disease characterisation and staging of solid cancers other than brain tumours. Results The literature search yielded 449 scientific articles. After screening titles and abstracts and applying inclusion and exclusion criteria, we selected 173 meta-analyses to assess the strength of evidence. One article was selected from references. Sixty-four meta-analyses were finally considered. The current evidence corroborates the role of [18F]FDG as the main player in molecular imaging; PSMA tracers are useful in staging and re-staging prostate cancer; somatostatin-targeting peptides (e.g. [68Ga]Ga- DOTA-TOC and -TATE) or [18F]DOPA are valuable in neuroendocrine tumours (NETs). FAPI has emerged in gastric cancer assessment. According to search and selection criteria, no satisfactory meta-analysis was selected for the diagnosis/detection of oesophageal cancer, the diagnosis/detection and N staging of small cell lung cancer and hepatic cell carcinoma, the diagnosis/detection and M staging of melanoma and Merkel cell carcinoma, cervical, vulvar and penis cancers, the N and M staging of lung and gastroenteropancreatic NET, testicular cancer, and chondrosarcoma, and the M staging of differentiated thyroid, bladder and anal cancers. Conclusion The comprehensive high-level evidence synthesised in the present umbrella review serves as a guiding compass for clinicians and imagers, aiding them in navigating the increasingly intricate seascape of PET examinations.

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PET/MRI in colorectal and anal cancers: an update

et al. 2023

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Diagnostic performance of [18F]-FDG PET/MR in evaluating colorectal cancer: a systematic review and meta-analysis

Cited by 18 publications

References 60 publications

From Dukes-MAC Staging System to Molecular Classification: Evolving Concepts in Colorectal Cancer

From Dukes-MAC Staging System to Molecular Classification: Evolving Concepts in Colorectal Cancer

Personalised PET imaging in oncology: an umbrella review of meta-analyses to guide the appropriate radiopharmaceutical choice and indication

PET/MRI in colorectal and anal cancers: an update

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