Diagnostic performance of narrowed spectrum endoscopy, autofluorescence imaging, and confocal laser endomicroscopy for optical diagnosis of colonic polyps: a meta-analysis

Wanders, Linda K; East, James E.; Uitentuis, Sanne E.; Leeflang, Mariska; Dekker, Evelien

doi:10.1016/s1470-2045(13)70509-6

Cited by 145 publications

(120 citation statements)

References 96 publications

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“…With a focus on autofluorescence emitted by normal tissues in response to excitation rays, we examined whether diagnostic accuracy could be improved by applying PDD. At present, although diagnostic methods employing autofluorescence are widely performed with bronchoscopy and colonoscopy, [4][5][6] there are few reports on such methods using a thoracoscope for intrathoracic malignancy. 9) While applying the autofluorescence imaging system for bronchoscopy, we conducted a study on the diagnosis of intrathoracic malignancy using thoracoscopy with autofluorescence imaging.…”

Section: Discussionmentioning

confidence: 99%

“…In the 1990s, autofluorescence bronchoscopy using these principles was developed 3) and has since been further refined and applied to diagnosis in various fields. [4][5][6] This study aimed to establish a diagnostic method using a device composed of a thoracoscope (rigid scope) equipped with the autofluorescence imaging system for intrathoracic malignancy.…”

Section: Photodynamic Diagnoses Of Malignant Pleural Diseases Using Tmentioning

confidence: 99%

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Photodynamic Diagnoses of Malignant Pleural Diseases Using the Autofluorescence Imaging System

Kitada

Ohsaki

Matsuda

et al. 2014

Ann Thorac Cardiovasc Surg

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Background: We conducted a study on photodynamic diagnosis (PDD) using autofluorescence in video-assisted thoracic surgery for minute intrathoracic small dissemination or early malignant pleural mesothelioma. Methods: Autofluorescence is the spontaneous emission of light that occurs when mitochondria, lysosomes, and other intracellular organelles absorb light. In normal tissues, green autofluorescence of approximately 520 nm is observed in response to 400-450 nm blue excitation rays. However, in cancer lesions, green autofluorescence is reduced due to thickening of the mucosal epithelium, a decrease in autofluorescent substances, etc., and the color spectrum thus shifts to red-violet. This phenomenon is the basis of PDD. Results: The color spectrum shift was observed in all tumors located on the pleural surface but not in cases with pleural fibrous disease. Among patients with primary lung cancer, those with pleural infiltration (pl) scores of 1 or greater showed color spectrum shifts due to reduced autofluorescence. Conclusion: Localization of pleural lesions by autofluorescence imaging was found to be useful. In primary lung cancer cases, differentiation between pl0 and pl1 lesions appears to be useful for determining therapeutic strategies including surgical procedures.

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Section: Discussionmentioning

confidence: 99%

Section: Photodynamic Diagnoses Of Malignant Pleural Diseases Using Tmentioning

confidence: 99%

Photodynamic Diagnoses of Malignant Pleural Diseases Using the Autofluorescence Imaging System

Kitada

Ohsaki

Matsuda

et al. 2014

Ann Thorac Cardiovasc Surg

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“…The overall sensitivity, specificity, and real-time negative predictive value of AFI in the diagnosis of adenoma were 86.7, 65.9, and 81.5 %, respectively. AFI showed good sensitivity but lower specificity than the other IEE methods [39]. Rotondano et al reported the accuracy of AFI in the differentiation of colorectal neoplasms, AFI alone showed poor accuracy but the combined use of AFI and NBI improved the accuracy (84 %), which was superior to NBI alone (P = 0.064) [24].…”

Section: Characterization Of Colorectal Lesionsmentioning

confidence: 97%

“…In comparison to NBI, AFI is more accurate when the lesion is clearly detected as green or magenta. However, AFI is not useful for the diagnosis of lesions in which the color is between green and magenta [39].…”

Section: Characterization Of Colorectal Lesionsmentioning

confidence: 99%

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Moriichi

Fujiya

Okumura

2016

Clin J Gastroenterol

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Image-enhanced endoscopy (IEE) has been developed and is applied in the clinical setting throughout the world. Most reports regarding IEE have evaluated the efficacy of narrow-band imaging (NBI) in the diagnosis of gastrointestinal disorders. Although autofluorescence imaging (AFI) is a form of IEE, its usefulness remains unclear. The present review focused on the efficacy of AFI in the diagnosis of colorectal disease, particularly neoplasia and ulcerative colitis (UC). AFI-based diagnoses are made via the subjective judgment of the color on the monitor. The efficacy of AFI in detection and differentiation in patients with colorectal neoplastic lesions remains controversial, which may be dependent on the study design and the diagnostic procedures. Although the number of the reports related to UC is very small, most suggest that AFI is effective in UC patients. AFI is distinct from other modalities in that it can quantitatively assess the lesion based on the fluorescence intensity without any morphological assessments. AFI could be useful for patients with colorectal disease.Keywords Autofluorescence imaging (AFI) Á Colorectal neoplasia Á Ulcerative colitis (UC) Á Colitis-associated cancer Á Narrow-band imaging (NBI) Á Image-enhanced endoscopy (IEE) Á White light endoscopy (WLE)

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“…It filters leads to the use of ambient light of wave lengths of 440 to 460 nm and 540 to 560 nm (peaks of light absorption of haemoglobin) which results in an increased contrast for superficial microvessels and in greater clarity of mucosal surface structures, recognizing the neoplastic tissue by its increased angiogenesis, therefore enabling the optical diagnosis, even predicting deep submucosal invasive carcinoma when using NBI international colorectal endoscopic (NICE) classification (31,32). A large meta-analysis of 56 studies using NBI for optical diagnosis found overall sensitivity to be 91% (95% CI 88.6-93%), specificity 85.6% (95% CI 81.3-89.0%) and negative predictive value of 82.5% (95% CI 75.4-87.9%) [33]. American Society for Gastrointestinal Endoscopy (ASGE) supports its clinical use for optical diagnosis of diminutive polyps [34].…”

Section: Introductionmentioning

confidence: 99%

Advances in endoscopic diagnosis of colorectal cancer

Čavlina¹,

Rustemović²

2017

Rad Hrvatske akademije znanosti i umjetnosti

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SummaryColorectal cancer (CRC) is the third most commonly diagnosed malignant tumor and the fourth leading cause of cancer death in the world. Since it is known that most of colorectal cancers arise from adenomatous polyps, screening programmes were developed in order to improve detection of polyps and early diagnosis of carcinoma. Colonoscopy is the gold standard for diagnosis of CRC. Because of its high adenoma missing rates and lower ability to differentiate between benign and malignant lesions novel techniques are being developed in order to improve mucosal visualization, reduce adenoma missing rates and enable in-vivo optical diagnosis. Methods can roughly be divided into three categories, ones that present improved visualization techniques (endoscopes with increased field of view, auxiliary imaging devices, so called addon devices), ones that enable more detail tissue characterization presenting the possibility for virtual biopsy (conventional or virtual chromoendoscopy, confocal laser endomicroscopy and endocytoscopy), and other minimally or non-invasive techniques.Further investigation is needed, but hopefully these innovations with continuous technical improvement might help to reduce the colorectal cancer incidence and mortality.

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Diagnostic performance of narrowed spectrum endoscopy, autofluorescence imaging, and confocal laser endomicroscopy for optical diagnosis of colonic polyps: a meta-analysis

Cited by 145 publications

References 96 publications

Photodynamic Diagnoses of Malignant Pleural Diseases Using the Autofluorescence Imaging System

Photodynamic Diagnoses of Malignant Pleural Diseases Using the Autofluorescence Imaging System

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Advances in endoscopic diagnosis of colorectal cancer

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