Diagnostic Pitfalls of Rare Urinary Bladder Tumors: Differential Diagnosis of Lymphoma-Like Carcinoma of the Bladder—A Clinicopathologic Study and Literature Review

Understanding the Genetic Landscape of Small Cell Carcinoma of the Urinary Bladder and Implications for Diagnosis, Prognosis, and Treatment

“…Although not required for the diagnosis of small cell carcinoma of the urinary bladder, immunohistochemical stains can be helpful (Table) for differentiation of coexisting urothelial carcinoma elements (either urothelial carcinoma [coexisting in 55%-70%] or urothelial carcinoma with squamous differentiation [coexisting in 10%]) and invasive small cell carcinoma of the prostate . Adjunct staining may help differentiate between other tumors, such as malignant lymphoma, lymphoepithelioma-like carcinoma, and poorly differentiated carcinomas …”

Lymphoepithelioma-like carcinoma of the urinary bladder:A rare case report

“…[ 1 ] Urothelial carcinoma is the most common type of bladder malignancy accounting for more than 90% cases. [ 2 3 ] Lymphoepithelioma-like carcinoma (LELC) is an undifferentiated form of carcinoma consisting of poorly differentiated epithelial cells with dense lymphoid cell infiltration. LELC was initially described in the nasopharynx and was subsequently reported in multiple organ system including various sites in the head and neck, lung, cervix, stomach, skin, breast, etc.…”