Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer

Liao, Wenxin; Li, Wei; Li, Yang; Liu, Tingting; Wang, Ying; Feng, Dan; Shen, Fujin

doi:10.1007/s00432-022-04465-5

Cited by 7 publications

(2 citation statements)

References 38 publications

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“…In a recent publication, the high CD177 levels discriminated against non‐survivors patients with COVID‐19 [32]. Also, in ovarian cancer, CD177 expression on tumour tissue is related to tumour malignancy and a bad prognosis [33], while in breast and cervical cancers, it is related to shorter overall survival [34, 35].…”

Section: Discussionmentioning

confidence: 99%

Dysregulated neutrophil extracellular traps formation in sepsis

Mulet,

Osuna‐Gómez,

Zamora

et al. 2023

Immunology

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The migration and antimicrobial functions of neutrophils seem to be impaired during sepsis and contribute to the dysregulation of immune responses and disease pathogenesis. However, the role of neutrophil extracellular traps (NETs) remains to be clarified. The study aimed to analyse sequential phenotypic and functional changes of neutrophils during the time following the diagnosis of sepsis. We prospectively enrolled 49 septic and 18 non‐septic patients from the intensive care unit (ICU) and emergency room (ER) and 20 healthy volunteers (HV). Baseline blood samples from septic and non‐septic patients were collected within 12 h of admission to the hospital. Additional septic samples were drawn at 24, 48 and 72 h after baseline. Neutrophil phenotype and degranulation capacity were assessed by flow cytometry and NET formation was quantified by fluorescence. Neutrophils from septic patients exhibited increased CD66b, CD11b and CD177 expression but displayed reduced NET formation at baseline compared with non‐septic patients and HV controls. Neutrophils expressing CD177 interacted less with platelets, were related to reduced NETosis and tended to indicate a worse sepsis outcome. In vitro experiments revealed that neutrophil function is compromised by the origin of sepsis, including the pathogen type and the affected organ. Assessing a decision tree model, our study showed that CD11b expression and NETosis values are useful variables to discriminate septic from non‐septic patients. We conclude that sepsis induces changes in neutrophil phenotype and function that may compromise the effective capacity of the host to eliminate pathogens.

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Section: Discussionmentioning

confidence: 99%

Dysregulated neutrophil extracellular traps formation in sepsis

Mulet,

Osuna‐Gómez,

Zamora

et al. 2023

Immunology

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“…In the eld of cancer, CD177 is considered to be a doubleedged role in afecting the clinical remarkable and prognosis value in variety cancer. Overexpression of CD177 importantly association with awful outcome in ovarian and pancreatic ductal adenocarcinoma but association with a excellent outcome in breast cance [9] [10]. Importantly, currently research has demonstrated that CD177 could improve the inhibitory function of tumor-in trating Treg cells (TC) in the TME, and blocking CD177 with antibodies in CD177 + tumor-in trating cells may be a novel target for antitumor immunotherapy [11].…”

Section: Introductionmentioning

confidence: 99%

Clinical Plasma Cells-related Genes to Aid Therapy in Colon Cancer

Zhang

Feng

Zhang

et al. 2023

Preprint

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Tumor immune microenvironment (TIME) of colon cancer (CC) shows quite a lot immune cell infiltration (IMI), and have been identified to be extensively drawn into the evolution of CC. Accumulated evidence demonstrated that plasma cells (PC) play an extremely significance role in advance of antitumor immune. Nonetheless, comprehensive analysis of PC infiltration in clinical prognosis and immunotherapy was poor in CC. This reasearch systematically addresses the gene expression model and clinical information of colon cancer patients (CCP) downloaded from the TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) databases in the current study. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), GSVA, and the MAlignant Tumors using Expression data (ESTIMATE) algorithm were employed to research the potential mechanism and pathways. Immunophenoscore (IPS) was executed to evaluate immunotherapeutic significance of risk score (RS). Half maximal inhibitory concentration (IC50) of chemotherapeutic medicine was predicted by employing the pRRophetic algorithm. Herein, 513 CC samples (including 472 tumor samples and 41 normal samples) were collected from TCGA-GDC database. Significant black module and 313 candidate genes were considered as PC-related genes by accessing WGCNA. Five pivotal genes were established through multiple analysis, which perform excellent prognostic. Then, we futher to explored underlying correlation between RS with tumor mutation burden (TMB). In addition, RS obviously correlated with various of tumor immune microenvironment (TIME). Different risk CC samples showed various signaling pathways activity and pivotal different sensitivities to administering chemotherapy. At the end, the biological roles of CD177 gene were uncovered in CC.

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