Diagnostic Ultrasound: Effects on the DNA and Growth Patterns of Animal Cells

Liebeskind, Doreen; Bases, Robert; Elequin, Flora; Neubort, Simon; Leifer, Robin; Goldberg, Robert M.; Koenigsberg, Mordecai

doi:10.1148/131.1.177

Cited by 94 publications

(14 citation statements)

References 25 publications

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“…It was observed earlier that exposure to pulsed Doppler ultrasound induced sister chromatid exchanges (Barnett et al, 1987), and caused other detectable damage on the human genome (Garaj-Vrhovac and Kopjar, 1999a,b) as well as on male mouse germ cells (Moutschen et al, 1986). Ultrasound of diagnostic intensities impaired the DNA and growth patterns of animal cells (Fuciarelli et al, 1995;Liebeskind et al, 1979). Most readily disturbed are actively dividing cells (Barnett et al, 1997).…”

Section: Introductionmentioning

confidence: 96%

“…Reports on harmful effects of diagnostic ultrasound on human chromosomes are contradictory (Liebeskind et al, 1979), possibly due to different ultrasonic equipment and the exposure conditions studied. However, our previous studies on occupationally exposed medical personnel indicated significantly disturbed cytogenetic endpoints compared with the unexposed control population (Garaj-Vrhovac et al, 1997;Garaj-Vrhovac and Kopjar, 1999a,b;Garaj-Vrhovac and Kopjar, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Investigation into possible DNA damaging effects of ultrasound in occupationally exposed medical personnel — the alkaline comet assay study

Garaj-Vrhovac

Kopjar

2005

J. Appl. Toxicol.

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In the present paper the possible DNA damaging effects of ultrasound in occupationally exposed medical personnel were investigated using the alkaline comet assay. The extent of DNA migration in peripheral blood leucocytes was measured. Parameters of the comet assay were studied in 30 medical workers occupationally exposed to ultrasound and in 30 corresponding unexposed control subjects. It was found that the subjects who were occupationally exposed to ultrasound for various periods of time showed a highly significant increase in levels of DNA damage compared with the control. The results obtained have confirmed the usefulness of the alkaline comet assay as a sensitive biodosimetric method, reflecting the current level of DNA damage and/or repair in peripheral blood leucocytes of ultrasound-exposed subjects. In spite of their limitations, the results of the present investigation indicate that individuals occupationally exposed to ultrasound may experience an increased genotoxic risk, emphasizing the need for more research into the nature and extent of the biological consequences to medical personnel working with ultrasonic equipment.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Investigation into possible DNA damaging effects of ultrasound in occupationally exposed medical personnel — the alkaline comet assay study

Garaj-Vrhovac

Kopjar

2005

J. Appl. Toxicol.

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“…3, MARCHiAPRlL 1985 the softening of scar tissue, was probably, in part, due to a nonthermal mechanism. Lepeschkin and Goldman (1949) concluded from some of the early ultrasound investigations, on a number of types of cells, that the changes observed did not resemble those caused by heat but rather those produced by a nonthermal mechanism. Some of the reported research conducted at different atmospheric pressures suggest that cavitation is, at least, partially involved in the production of some effects (Lehmann and Herrick 1953, Hug and Pape 1954, Gerstein 1954, Webster et al 1978, Al-Hashimit and Chapman 1980, Frizzell et al 1982, Morton et al 1983, and Ross and Edmonds 1983.…”

Section: Discussionmentioning

confidence: 99%

Compilation of reported biological effects data and ultrasound exposure levels

Stewart¹,

Stewart²,

Moore³

et al. 1985

J of Clinical Ultrasound

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A compilation of reports of biological effects and related ultrasound exposure levels can be useful in the identification of trends in effects data that may be developing in the literature. The exposures in the experiments reviewed were at frequencies used in medicine. For short (10 minutes or less) continuous wave exposure, with the exception of behavioral effects where variable results have been observed, this tabulation did not identify any in vivo or in vitro effects at spatial peak, temporal average (SPTA) intensities less than 100 mW/cm2. However, a number of effects using pulsed sources with SPTA intensities under this level have been reported. There are several frequently recurring topics in recent reports which include developmental effects and microstructure changes at the cellular level. In addition to animal investigations, there are some limited human epidemiological studies reporting an association between medical ultrasound exposure in utero and developmental effects. Although sufficient research has not been completed to draw conclusions, the findings deserve further investigation. A systematic pattern of directed research on a large scale is not apparent. The available data consist of many scattered studies conducted by individual investigators and groups throughout the world.

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“…On the other hand, Liebeskind et field parameters and other dosimetrically imporal. 6 • 7 discussed in some detail standing wave effects tant data. when employing polypro~ylene tubes as the insoMorris et al 5 and Barrass et aJ.…”

Section: Dosimetric Considerationsmentioning

confidence: 99%

Sister chromatid exchange and ultrasound.

Goss¹

1984

Journal of Ultrasound in Medicine

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Reported effects of ultrasound on sister chromatid exchange have been contradictory. These studies are discussed and their results , including ultrasonic dosimetry and biologic considerations, are compared. In the few studies showing positive effects, the magnitude was small, and the eflects occurred as a result of in vitro exposure. Based on a review of these reports, there does not appear to be sufficient reason to alter presently held views on the safety of clinical ultrasound. (Key words: sister chromatid exchange; ultrasound safety; biologic effects) Several papers have recently appeared in the ultrasonic bioeffects literature that examine the effect of ultrasound on sister chromatid exchange (SCE) frequency in a number of biological sys tems.

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Diagnostic Ultrasound: Effects on the DNA and Growth Patterns of Animal Cells

Cited by 94 publications

References 25 publications

Investigation into possible DNA damaging effects of ultrasound in occupationally exposed medical personnel — the alkaline comet assay study

Investigation into possible DNA damaging effects of ultrasound in occupationally exposed medical personnel — the alkaline comet assay study

Compilation of reported biological effects data and ultrasound exposure levels

Sister chromatid exchange and ultrasound.

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