Diagnostic utility of anti-cyclic citrullinated peptide antibodies for rheumatoid arthritis in patients with active lung tuberculosis

Mori, Shunsuke; Naito, Hiromichi; Ohtani, Sumire; Yamanaka, Tohru; Sugimoto, Mineharu

doi:10.1007/s10067-008-1035-5

Cited by 14 publications

(8 citation statements)

References 37 publications

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“…Anti-CCP has also been shown to detect early RA in patients with active tuberculosis [105]. For SLE patients with chronic destructive/deforming arthritis and patients with pulmonary tuberculosis who are anti-CCP positive, the ratio of anti-CCP to unmodified arginine-containing peptide (CAP) differs between these and RA patients, providing a means for differential diagnosis [85, 106–108].…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Serum Biomarkers Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor as Tests for Rheumatoid Arthritis

Taylor

Gartemann

Hsieh

et al. 2011

Autoimmune Diseases

118

100

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This systematic review assesses the current status of anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) tests in the diagnosis and prognosis of rheumatoid arthritis (RA). We reviewed publications on tests and biomarkers for early diagnosis of RA from English-language MEDLINE-indexed journals and non-MEDLINE-indexed sources. 85 publications were identified and reviewed, including 68 studies from MEDLINE and 17 non-MEDLINE sources. Anti-CCP2 assays provide improved sensitivity over anti-CCP assays and RF, but anti-CCP2 and RF assays in combination demonstrate a positive predictive value (PPV) nearing 100%, greater than the PPV of either of the tests alone. The combination also appears to be able to distinguish between patients whose disease course is expected to be more severe and both tests are incorporated in the 2010 ACR Rheumatoid Arthritis Classification Criteria. While the clinical value of anti-CCP tests has been established, differences in cut-off values, sensitivities and specificities exist between first-, second- and third-generation tests and harmonization efforts are under way. Anti-CCP and RF are clinically valuable biomarkers for the diagnosis and prognosis of RA patients. The combination of the two biomarkers in conjunction with other clinical measures is an important tool for the diagnosis and management of RA patients.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of Serum Biomarkers Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor as Tests for Rheumatoid Arthritis

Taylor

Gartemann

Hsieh

et al. 2011

Autoimmune Diseases

118

100

View full text Add to dashboard Cite

show abstract

“…In contrast, Mori et al (12) reported that anti-CCP antibodies were positive in 6 of 89 patients with active pulmonary TB (6.7%) and 0.4% in the control group (n=267). Although anti-CCP levels were higher compared to healthy controls, it was suggested that anti-CCP levels could be used in the early diagnosis of RA in patients with active TB.…”

Section: Discussionmentioning

confidence: 86%

“…Although anti-CCP levels were higher compared to healthy controls, it was suggested that anti-CCP levels could be used in the early diagnosis of RA in patients with active TB. It was also stated that anti-CCP might become positive years before RA manifestations and these patients might develop RA at a later time period (12).…”

Section: Discussionmentioning

confidence: 99%

Anti-CCP Antibody and Rheumatoid Factor Positivity in a Case of Tuberculosis Arthritis

et al. 2010

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ÖzetTüberküloz (TB) iskelet sisteminde vertebraları ve yük binen eklemleri etkiliyebilir. Periferik eklem tutulumunda romatoid artrit (RA)'i taklit eden klinik, laboratuar ve radyolojik bulgular oluşturabilir. TB, günümüzde RA'nın erken tanısında kullanılmak-ta olan romatoid faktör(RF) ve anti-cyclic citrullinated peptide (CCP) pozitifliği oluşturabilir. Bu durum klinik tanıda zorluklara yol açar. İlave olarak TB artritdeki tanısal zorluklar bu durumu daha da karmaşık hale getirir. Biz burada Anti-CCP ve RF pozitif olan TB artritli bir vaka sunarak bu duruma dikkat çekmeyi amaç-ladık. (Turk J Rheumatol 2010; 25: 95-8 Abs tractTuberculosis (TB) can affect vertebras and joints bearing weight. It can resemble clinic signs, radiological and laboratory findings of rheumatoid arthritis (RA) involving peripheral joints. TB can make rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) positive, which are used in the diagnosis of RA arthritis. Therefore, this causes some difficulties in clinic diagnosis. Additionally, the diagnostic problems in TB arthritis can be more complicated. We aimed to attract attention to this situation by presenting a case of TB arthritis in which anti-CCP and RF are positive. (Turk J Rheumatol 2010; 25: 95-8)

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“…However, anti-CCP antibodies have not been previously described in patients with arthritis induced by BCG. 29,30 This can be explained by anti-CCP antibody induction and maintenance of an immune response to chronic granulomatous inflammatory tissue rather than a direct response to the Mycobacterium. 27,28 Nevertheless, positive anti-CCP antibody has been demonstrated in patients with active tuberculosis in 6.7% to 37% of cases.…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid Arthritis, Vasculitis, and Mononeuritis Multiplex After BCG Used in a Patient With Bladder Carcinoma

Reznikova¹,

Tyree²,

Bonilla³

2012

Infectious Diseases in Clinical Practice

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Background: The incidence of patients with serious adverse effects after Bacille Calmette-Guerin (BCG) instillation for bladder cancer is approximately 0.5%. We report a patient with bladder cancer treated with BCG who subsequently developed rheumatoid arthritis associated with polyneuropathy and vasculitis.Case: A 55-year-old white man with bladder cancer was treated with instillation of BCG. After the third treatment, the patient developed symmetrical arthralgias and arthritis in the hands, feet, elbows, and knees associated with a burning sensation of the hands and soles bilaterally. An electromyogram nerve conduction study showed severe polyneuropathy. A muscle biopsy was compatible with vasculitis. Bacille Calmette-Guerin was discontinued, and the patient was started on isoniazid/vitamin B6, prednisone, and methotrexate. His symptoms resolved within 6 weeks of therapy.Discussion: Bacille Calmette-Guerin is able to induce an autoimmune phenomenon through a mechanism of molecular mimicry. This hypothesis could explain the clinical manifestations and the presence of markers of autoimmunity seen in our patient. Monoclonal antibodies and clones of T cells derived from Mycobacterium tuberculosis against several human tissues have been found. We postulate that our patient's positive rifampin, antinuclear antibodies and anti-cyclic citrullinated peptide antibodies by molecular mimicry to as well as the inflammatory response directed against BCG.Conclusion: Bacille Calmette-Guerin immunotherapy for bladder cancer can induce a clinical picture of rheumatoid arthritis associated with polyneuritis multiples and vasculitis.

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Diagnostic utility of anti-cyclic citrullinated peptide antibodies for rheumatoid arthritis in patients with active lung tuberculosis

Cited by 14 publications

References 37 publications

A Systematic Review of Serum Biomarkers Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor as Tests for Rheumatoid Arthritis

A Systematic Review of Serum Biomarkers Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor as Tests for Rheumatoid Arthritis

Anti-CCP Antibody and Rheumatoid Factor Positivity in a Case of Tuberculosis Arthritis

Rheumatoid Arthritis, Vasculitis, and Mononeuritis Multiplex After BCG Used in a Patient With Bladder Carcinoma

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