Diagnostic Utility of Different Blood Components in Gene Expression Analysis of Sepsis

Maslove, David; Marshall, John C.

doi:10.1097/shk.0000000000000511

Shock

2016

DOI: 10.1097/shk.0000000000000511

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Diagnostic Utility of Different Blood Components in Gene Expression Analysis of Sepsis

David Maslove

John C. Marshall

Abstract: Our results support the use of whole blood to derive gene expression data in sepsis studies investigating novel diagnostics and subtype discovery. This strategy has a number of practical advantages, and the resulting data also have potential utility in developing molecular classifications of sepsis syndromes.

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Cited by 4 publications

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“…On this subject, Maslove et al (7) in the “clinical aspect” section of this edition of Shock, report on their systemic analysis on 22 separate gene expression studies of whole blood (15 studies) or leukocyte fraction (7 studies) of septic patients. The data was obtained from Gene Expression Omnibus (GEO) database.…”

mentioning

confidence: 99%

What's New in Shock? March 2016

Amini-Nik

Jeschke²

2016

Shock

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mentioning

confidence: 99%

What's New in Shock? March 2016

Amini-Nik

Jeschke²

2016

Shock

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The search for biomarkers in the critically ill: a cautionary tale

Moran,

Solomon

2018

Critical Care and Resuscitation

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Mechanisms and treatment of organ failure in sepsis

2018

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Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction. Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the management and treatment of patients and for the development of potential new therapies. In clinical practice, six major organ systems - the cardiovascular (including the microcirculation), respiratory, renal, neurological, haematological and hepatic systems - can be assessed and monitored, whereas others, such as the gut, are less accessible. Over the past 2 decades, considerable amounts of new data have helped improve our understanding of sepsis pathophysiology, including the regulation of inflammatory pathways and the role played by immune suppression during sepsis. The effects of impaired cellular function, including mitochondrial dysfunction and altered cell death mechanisms, on the development of organ dysfunction are also being unravelled. Insights have been gained into interactions between key organs (such as the kidneys and the gut) and organ-organ crosstalk during sepsis. The important role of the microcirculation in sepsis is increasingly apparent, and new techniques have been developed that make it possible to visualize the microcirculation at the bedside, although these techniques are only research tools at present.

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Diagnostic Utility of Different Blood Components in Gene Expression Analysis of Sepsis

Cited by 4 publications

References 31 publications

What's New in Shock? March 2016

What's New in Shock? March 2016

The search for biomarkers in the critically ill: a cautionary tale

Mechanisms and treatment of organ failure in sepsis

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