Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-1 in infected neonates

Abstract

Serum sTREM-1 increases in infected neonates. Diagnostic accuracy of sTREM-1 either alone or in combination with IL-6 is not better than that of IL-6.

Can sTREM-1 predict septic shock & death in late-onset neonatal sepsis? A pilot study

“…They selected 143 pg/mL of plasma sTREM-1 as the best value for detecting infected neonates; however, sTREM-1 was not found to be more accurate than IL-6 in differentiating infected from non-infected neonates. 10 Our study of a population of LONS cases generated highly similar median and range values for plasma sTREM-1, 140 (70 to 518) pg/mL, to those reported by Sarafidis et al A crucial difference between their work and ours is that we aimed to identify the subset of LONS neonates who were prone to an unfavorable outcome (shock or death). Mazzucchelli et al recently published their findings for a cohort of 71 neonates, 16 of whom developed LONS and were compared to 16 non-infected neonates.…”

“…These two public hospitals have level II-III neonatal intensive care units and belong to the Servicios de Salud Network in Nuevo Leó n, Mexico. The inclusion criteria for this study population were as follows: inborn neonates; suspicion of LONS, defined as an infection occurring after 72 hours of life; a systemic inflammatory response syndrome based on the criteria of the International Pediatric Sepsis Consensus Conference and Haque 10,11 ; and a nosocomial sepsis predictive score (NOSEP-1) above 8 points. The NOSEP-1 is determined based on C-reactive protein level, neutrophil fraction, thrombocytopenia, fever, and prolonged parenteral nutrition.…”

“…The diagnosis of septic shock also depended on two or more of the following criteria: capillary refill time > 4 seconds; oliguria, with diuresis < 0.5 mL/h; and metabolic acidosis with a lactic acid level above 2 mmol/L. 10,11 Laboratory evidence of infection was a CRP >14 mg/L, neutrophilia >50% and thrombocytopenia <150000. These parameters for the diagnosis of infection were similar to those published elsewhere, 8 although we also considered fever >38 8C and total parenteral nutrition for !14 days, as are defined in the NOSEP-1 score.…”

SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS -1 (sTREM-1) AS aDIAGNOSTIC AND PROGNOSTIC MARKER FOR LATE-ONSET SEPSIS IN PRETERM NEONATES.

“…In our study, we found that sTREM-1 levels showed highly significant statistical decrease 48-72 hrs after administration of antibiotics in relation to initial sTREM-1 levels indicating that sTREM-1 is a useful monitoring marker for follow-up of septic neonates to observe the effect of treatment which is consistent with the results of Sarafidis et al (2010) and Saldir et al (2015). The main limitation in our study was small sized sample number which can be validated by further large scale studies before application to general population.…”

Preterm Newborns are Provided with Triggering Receptor Expressed on Myeloid Cells-1

“…The literature shows that TREM-I is a valuable tool for the diagnosis of infection (3)(4)(5)(6) and the soluble form (sTREM-I) seems an important marker for the diagnosis and prognosis of the sepsis (4)(5). The role of TREM-I has been mainly confirmed in adult patients, while few data are available for neonates, mainly focused on the soluble form (7)(8). Bacterial infections are an important cause of morbidity and mortality in neonates, particularly in pretenn newborns (9).…”