Diagnostic value of abnormal Q waves for identification of preclinical carriers of hypertrophic cardiomyopathy based on a molecular genetic diagnosis

Abstract

These findings suggest that Criterion 3 may be the most accurate diagnostic definition for HCM. Understanding the diagnostic value of abnormal Q waves may be useful in screening preclinical carriers of HCM.

Outcome of Patients With Hypertrophic Cardiomyopathy and a Normal Electrocardiogram

“…The 12-lead ECG is a fundamental initial diagnostic modality for the early evaluation of a patient suspected of having HCM; at times, it is the only sign of the disease in an otherwise asymptomatic individual (16). In prior investigations (17)(18)(19) of patients with mutations in cardiac myofilaments, ECG had a similar accuracy (sensitivity: ϳ60%, specificity: ϳ98%) in the diagnosis of HCM as echocardiography (left ventricular wall thickness: Ͼ13 mm).…”

Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction Subanalysis of MUSASHI-AMI

“…Q-wave was defined as follows: Q-wave >3 mm in depth and/or >0.04 s in duration in at least 2 leads except aVR. 16 Statistical Analysis Differences in the characteristics of patients between the 2 treatment groups were evaluated by Student's t-test in the case of continuous variables and chi-squared test for absolute categorical variables. Cumulative event curves of the study endpoint were plotted by the Kaplan-Meier method.…”

Fragmented QRS Predicts Heart Failure Progression in Patients With Hypertrophic Cardiomyopathy

“…Pathological Q waves were defined as follows based on previous studies: Q wave >1/4 of the ensuing R wave in depth and/or >40 ms in duration in at least 2 leads except aVR. 21 Giant negative T waves >10 mm in depth in any leads were defined as giant negative T waves. 22 …”