Diagnostic value of circulating microRNAs in thyroid carcinoma: A systematic review and meta‐analysis

Xu, Shilin; Tian, Yuzhou; Zhou, Ying; Liu, Li‐Qiao

doi:10.1111/cen.14217

Cited by 12 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AUC was 0.939 and the cutoff value was 2.205 (93.8% sensitivity and 88.7% speci city) for combined diagnosis of miR-17-5p and miR-424-5p. Previous studies also elicit that the combination of several different miRNAs, with improved sensitivity and speci city, has elevated diagnostic accuracy relative to individual miRNA [15,29]. Altogether, miR-17-5p and miR-424-5p both could be considered as biomarkers for EMT, and their combination had ampli ed this diagnostic e cacy.…”

Section: Discussionmentioning

confidence: 92%

miR-424-5p combined with miR-17-5p has high diagnostic efficacy for endometriosis

Lin¹,

Zeng

2022

Arch Gynecol Obstet

View full text Add to dashboard Cite

Purpose: Endometriosis (EMT) is a chronic benign disease with high prevalence. This study investigated the diagnostic value of serum miR-17-5p, miR-424-5p, and their combined expressions for EMT.Methods: A total of 80 EMT patients of reproductive age were included as the study subjects, and another 80 healthy women of reproductive age were selected as the control group. The whole blood samples of enrolled subjects were collected and clinical characteristics were recorded. The miR-17-5p, miR-424-5p, VEGFA, IL-4, and IL-6 levels in the serum were measured. ROC curve was used to evaluate the diagnostic e cacy of miR-17-5p and miR-424-5p expressions for EMT. Pearson correlation was performed to analyze the correlation of miR-17-5p and miR-424-5p with clinical indexes in EMT patients.Results: miR-17-5p and miR-424-5p were signi cantly downregulated in EMT patients. For the diagnosis of EMT, the AUC of miR-17-5p was 0.865 and cutoff value was 0.890 (91.3% sensitivity and 85% speci city), the AUC of miR-424-5p was 0.737 and cutoff value was 0.915 (98.8% sensitivity and 61.2% speci city), the AUC of miR-424-5p combined with miR-17-5p was 0.938 and cutoff value was 2.205 (93.8% sensitivity and 88.7% speci city), with the diagnostic e cacy higher than miR-424-5p or miR-17-5p alone. The expressions of miR-17-5p and miR-424-5p were negatively correlated with dysmenorrhea, infertility, pelvic pain, and rASRM stage, but not with age, BMI, menstrual disorder, and nulliparity. VEGFA, IL-4, and IL-6 were remarkably increased in EMT patients, and both were inversely associated with miR-17-5p and miR-424-5p.Conclusion: miR-424-5p combined with miR-17-5p has high diagnostic e cacy for EMT.

show abstract

Section: Discussionmentioning

confidence: 92%

miR-424-5p combined with miR-17-5p has high diagnostic efficacy for endometriosis

Lin¹,

Zeng

2022

Arch Gynecol Obstet

View full text Add to dashboard Cite

show abstract

“…Several meta-analyses have been recently published, which studied miRNAs as molecular biomarkers in the diagnosis of thyroid cancer. Of interest, Xu et al [5] found that the summary sensitivity, specificity, and AUROC of circulating miRNAs were 81%, 81%, and 0.88 for distinguishing thyroid cancers from benign thyroid nodules, respectively; and 81%, 85%, and 0.89 for distinguishing thyroid cancers from healthy controls, www.bjbms.org respectively. The results of that study were similar to ours.…”

Section: Discussionmentioning

confidence: 99%

“…MicroRNAs (miRNAs) are a class of endogenous non-coding RNA molecules that regulate transcription and translation, which have gained tremendous attention in research in the last two decades given their ability to regulate gene expression [5,10]. Through the induction of translational repression or silencing effects by complementary binding to target messenger RNAs (mRNAs), these molecules play an important role in the regulation of gene expression [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, it has been estimated that PTC is responsible for approximately 80-90% of all thyroid cancers [ 4 ]. It is important to emphasize that papillary structures can also be observed in benign or malignant thyroid diseases; however, the treatment options are varied [ 5 ]. Therefore, the diagnostic distinction between benign and malignant diseases is crucial in determining clinical management, which may spare patients from unnecessary surgery [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum microRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma: a meta-analysis

Dong

Huang

2022

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer. Several studies have proposed serum microRNAs (miRNAs) as novel biomarkers for diagnosing PTC. In this study, we conducted a meta-analysis aiming to investigate the overall diagnostic accuracy of serum miRNAs in PTC detection. Three online databases including PubMed, EMBASE and Cochrane Library were searched up to 1 May 2021. We systematically reviewed studies evaluating the value of serum miRNAs in diagnosing PTC, and then summarized the area under receiver operating characteristics curve (AUROC), sensitivity, specificity, and diagnostic odds ratio to assess the accuracy of serum miRNAs for the discrimination between patients with PTC and patients with benign thyroid nodules and healthy controls. We included 32 studies from 6 articles. Overall, there were 463 PTC patients, 334 patients with benign thyroid nodules, and 104 healthy controls. The results showed that the summary sensitivity and specificity were 76% (95% confidence interval [CI]: 68%‒83%) and 86% (95% CI: 80%‒91%), respectively, and that the summary AUROC was 0.89 (95% CI: 0.86‒0.91), when serum miRNAs were used for discriminating between PTC patients and those with benign nodules. On the other hand, the summary sensitivity and specificity of serum miRNAs for discriminating between PTC patients and healthy controls were 82% (95% CI: 77%‒86%) and 84% (95% CI: 76%‒90%), respectively, and the summary AUROC was 0.89 (95% CI: 0.86‒0.92). We found that serum miRNAs have good diagnostic performance for the discrimination between patients with PTC and patients with benign nodules and healthy controls, and thus have considerable potential as novel minimally invasive tools for detecting PTC.

show abstract

“…It was also stated that MiRNAs can help in the diagnosis of malignancy and may be helpful in avoiding unnecessary surgery. It was stated that cir-culating miRNAs should be added in current thyroid nodule evaluations (23) .…”

Section: Discussionmentioning

confidence: 99%

Are MicroRNA 190 and MicroRNA95-3P in the Circulation Can Be Used As Predictive Bioindicators in Differentiated Thyroid Cancer in Patients with Atypia of Undetermined Significance Based on Thyroid Fine Needle Aspiration Biopsy Results?

Ünsal¹,

Cartı²,

Ünübol³

et al. 2020

Terh

View full text Add to dashboard Cite

INTRODUCTION: It is not always possible to make a definitive diagnosis preoperatively with thyroid fine needle aspiration biopsy. Decision making is quite complicated in cases with atypical cells of undetermined significance. MicroRNAs have been shown to be associated with the development of neoplasia. For this purpose, we aimed to investigate the circulating microRNA 190 and microRNA 95-3P levels as a biomarker to distinguish benign and malign cases with preoperative atypical cells of undetermined significance diagnosis. METHODS: Patients with preoperative atypical cells of undetermined significance.diagnosis were included in the study. 29 malign and 29 benign patients were included. Venous blood samples isolated using a specific miRNA kit. RESULTS: According to the postoperative pathology results statistically significant between circulating miRNA 190 and miRNA 95-3p between cases with thyroid cancer. differences were detected. DISCUSSION AND CONCLUSION: It can be asserted that miRNA 95 and miRNA 190 assessment can help to differentiate thyroid cancer from benign thyroid nodules and may be useful in avoiding unnecessary surgery in patients with atypical cells of undetermined significance results.

show abstract

Diagnostic value of circulating microRNAs in thyroid carcinoma: A systematic review and meta‐analysis

Cited by 12 publications

References 20 publications

miR-424-5p combined with miR-17-5p has high diagnostic efficacy for endometriosis

miR-424-5p combined with miR-17-5p has high diagnostic efficacy for endometriosis

Serum microRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma: a meta-analysis

Are MicroRNA 190 and MicroRNA95-3P in the Circulation Can Be Used As Predictive Bioindicators in Differentiated Thyroid Cancer in Patients with Atypia of Undetermined Significance Based on Thyroid Fine Needle Aspiration Biopsy Results?

Contact Info

Product

Resources

About