Diagnostic value of combined prealbumin-to-fibrinogen and albumin-to-fibrinogen ratios in Hp-negative gastric cancer

Abstract

Background This study aimed to investigate the diagnostic value of prealbumin-to-fibrinogen ratio (PFR) and albumin-to-fibrinogen ratio (AFR) alone or in combination in Helicobacter pylori-negative gastric cancer (Hp-NGC) patients. Methods This study included 171 healthy controls, 180 Hp-NGC patients, and 215 Helicobacter pylori-negative chronic gastritis (HpN) patients. We compared the differences of various indicators and pathological characteristics between groups with Mann–Whitney U test and Chi-square test. The diagnostic value of PFR and AFR alone or in combination for Hp-NGC patients was assessed by the receiver operating characteristic (ROC) curve. Results PFR and AFR were related to the progression and clinicopathological characteristics of Hp-NGC. As the disease progressed, PFR and AFR values gradually decreased and were negatively related to the tumor size and depth of invasion. In addition, the area under the curves (AUCs) that resulted from combining PFR and AFR to distinguish Hp-NGC patients from healthy controls and HpN patients were 0.908 and 0.654, respectively. When combined with PFR and AFR in the differential diagnosis of tumors with a maximum diameter ≥ 5 cm and the T3 + T4 stage, the AUCs were 0.949 and 0.922; the sensitivity was 86.32% and 80.74%; and the specificity was 94.74% and 92.98%, respectively. Conclusions PFR and AFR may be used as diagnostic biomarkers for Hp-NGC. The combination of PFR and AFR was more valuable than each indicator alone in the diagnosis of Hp-NGC.

Fibrinogen-to-prealbumin ratio: A new prognostic marker of resectable pancreatic cancer

“…Therefore, more biomarkers are needed to help guide therapy and improve the accuracy of prognostic determinations for individual patients. As a novel serological prognostic marker, multiple studies have demonstrated that FPR can evaluate the prognosis of malignant tumors such as colorectal cancer, hepatocellular carcinoma, esophageal cancer and gastric cancer ( 13 – 15 , 35 ). A recent meta-analysis pointed out that high value of FPR is associated with poorer survival and increased risk of recurrence in cancer patients ( 36 ).…”

The role of preoperative FPR and FAR in prognostic evaluation of stages II and III radical colorectal cancer: A single-center retrospective study

“…[18,19] The inflammatory state associated with cancer has been widely recognized as symbol of tumor occurrence and progression and hyperfibrinogenemia and hypoalbuminemia were usually observed in patients with malignant tumors. [20] New studies [21][22][23][24][25] are constantly investigating the relationship between FPR and FAR and tumor prognosis, but the diagnostic role of FPR and FAR in CRC of different stages is remained unclear.…”

Application of Monocyte-to-Albumin Ratio and Neutrophil Percentage-to-Hemoglobin Ratio on Distinguishing Non-Small Cell Lung Cancer Patients from Healthy Subjects

“… 17 As important indicators of malnutrition and inflammation, anemia and hypoproteinemia are generally associated with poor prognosis and high mortality in cancer patients. 18 However, the problem of the above indicators is that each of them reflects either inflammatory or nutritional. The research also found that, compared to single indicator, the combination of inflammatory and nutritional indicators could help better diagnose cancer and predict prognosis.…”