Diagnostic Value of HE4, CA125 and Risk of Ovarian Malignancy Algorithm in Detecting Ovarian Cancer

Jafari-Shobeiri, Mehri; Parizad, Marzye; Nazari, Fatemeh; Ouladsahebmadarek, Elaheh; Sayyah-Melli, Manizheh; Mostafa-Gharabaghi, Parvin; Esmaili, Heidarali; Parizad, Mohammad Amin; Pouraliakbar, Yasmin; Sepasi, Farnaz

doi:10.15296/ijwhr.2015.43

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Several studies suggested HE-4 gene product has similar diagnostic sensitivity to that of CA-125, with an increased diagnostic specificity in patients with gynecologic malignancies compared with those with a benign gynecologic disease [9,13,28]. In contrast, many studies [19,20,37], stated that, HE-4 alone or in combination with CA-125 do not achieve better diagnostic performance than CA-125 alone. Many studies stated; combined HE-4 and CA-125 improve the diagnostic value than each of them alone [3,7,9,17,22].…”

Section: Discussionmentioning

confidence: 99%

Combined Human Epididymis 4 and Carbohydrate Antigen 125 Serum Protein Levels Diagnostic value in Ovarian Cancer

Teama¹,

Gamal²,

Teama³

2018

Madridge J Cancer Stud Res

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Objective: Human Epididymis 4 (HE-4) protein, a new candidate for ovarian cancer detection shows promising diagnostic value for ovarian cancer diagnosis, this study aimed to assess the diagnostic significance of combined Human Epididymis 4 and Carbohydrate Antigen 125 (CA-125) serum protein levels in ovarian cancer detection. Subjects and Methods:A clinical case control study include; forty nine subjects; patients with ovarian cancer (n=33), non-cancer control group (n=16). Serum protein levels of HE-4 were measured using an enzyme linked immune sorbent assay (ELISA). All data were analyzed by SPSS software (version 21.0.0; IPM SPSS, Chicago, IL, USA). Results:The results showed that increased serum protein concentration of HE-4 (pMol/L) and CA-125 (U/ml) in the ovarian cancer group mean (SD)/median (range) 329.61±336.55/199 (28.72-1064) and 521.36±572.60/287 (10.50-2377), than non-cancer control group 64.80±38.51/54.53 (21 -160) and 28.35±10.80/28 (10-50) respectively (p<0.05). The receiver operating characteristic curve, the area under the curve (ROC-AUC) (95%CI) values of serum HE-4 was 0.85 (0.74-0.95). The sensitivity and specificity of HE-4 in diagnosing malignant ovarian tumors was 84.84% and 75.00%, respectively at ideal cutoff point that provided the best and highest accuracy in our own study and its level was related to clinical staging. Conclusion:Our study concludes that HE-4 protein a new candidate biomarker has a comparable diagnostic value for ovarian cancer detection compared to CA-125 with better performance of HE4 in our selected group of patients and combined serum protein levels of HE-4 with CA-125 improve the sensitivity obtained with only one tumor marker and their level was related to clinical staging. But, due to, "abnormally high concentrations of CA-125 found in many conditions and little is known about HE-4 diagnostic specificity till now in other benign and malignant conditions", both markers can be used for diagnosis and follow-up of patients taking in consideration their diagnostic specificity.

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Section: Discussionmentioning

confidence: 99%

Combined Human Epididymis 4 and Carbohydrate Antigen 125 Serum Protein Levels Diagnostic value in Ovarian Cancer

Teama¹,

Gamal²,

Teama³

2018

Madridge J Cancer Stud Res

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“…A recent study has shown that patients diagnosed with ovarian tumors have a high chance of survival upon surgical operation and tumor removal [3]. It is very important to evaluate the risk of ovarian cancer by pelvic mass assessment and by referring patients to the suitable health care centres [4].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of tumor biomarkers CA125 and CA72-4 in differentiation of epithelial ovarian cancer and endometrioma

Mehri¹,

Sepasi²,

Tabrizi³

et al. 2018

biomedicalresearch

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Ovarian cancer is the leading cause of gynecological malignancy-related mortality. CA125 level in patients with Epithelial Ovarian Cancer (EOC) and endometrioma can frequently be high. CA72-4 level was also elevated in several carcinomas including ovarian cancer. Due to its lack of specificity, however, this marker has a limited role in the differential diagnosis between EOC and endometrioma. In this research, we studied the levels of biomarkers CA125 and CA72-4 to determine their potential role in the differential diagnosis of endometrioma and EOC. For this goal, biomarkers CA125 and CA72-4 were identified in 75 patients with ovarian cancer and 75 patients with endometrioma. Cut-off levels for CA125 and CA72-4 were considered 35 U/ml and 3.8 U/ml, respectively. The data have been analyzed by SPSS, with a p-value<0.05 considered significant. Both markers CA125 and CA72-4 were remarkably elevated in EOC (p=0.001). Areas under the ROC curve for CA125 and CA72-4, with sensitivity of 0.48 and specificity of 0.52, were 0.633 and 0.624, respectively. The differences were not significant. It has been shown that CA125 and CA72-4 serum levels are elevated in patients with EOC; however, this did not lead to detection of malignancy. This means that CA72-4 level does not demonstrate a significant difference in malignancy diagnoses when compared to the use of CA125 alone.

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Comparison of Serum Human Epididymis Protein (HE4), Carbohydrate Antigen 125(CA125) and Risk of Ovarian Malignancy Algorithm (ROMA) as Markers in Ovarian Cancer: A Systematic Review and a Meta-analysis

Fakhar

Rezaie-Tavirani

Zali

et al. 2018

Indian J Gynecol Oncolog

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Diagnostic Value of HE4, CA125 and Risk of Ovarian Malignancy Algorithm in Detecting Ovarian Cancer

Cited by 4 publications

References 8 publications

Combined Human Epididymis 4 and Carbohydrate Antigen 125 Serum Protein Levels Diagnostic value in Ovarian Cancer

Combined Human Epididymis 4 and Carbohydrate Antigen 125 Serum Protein Levels Diagnostic value in Ovarian Cancer

Diagnostic value of tumor biomarkers CA125 and CA72-4 in differentiation of epithelial ovarian cancer and endometrioma

Comparison of Serum Human Epididymis Protein (HE4), Carbohydrate Antigen 125(CA125) and Risk of Ovarian Malignancy Algorithm (ROMA) as Markers in Ovarian Cancer: A Systematic Review and a Meta-analysis

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