Diagnostic Value of Increased Urinary Output of Noradrenaline and Adrenaline in Phæochromocytoma

Engel, Ashley; Euler, U. S. v.

doi:10.1016/s0140-6736(50)91342-0

Cited by 120 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is not surprising that the release of some active material causes a rise of blood pressure, and theoretically it should be possible to demonstrate active material in the blood. This is, however, not easy, and Engel and Euler (1950) showed that a large amount of noradrenaline can be found in urine.…”

Section: Discussionmentioning

confidence: 99%

Excretion of Pressor Amines in Phaeochromocytoma

Burn¹

1953

BMJ

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Excretion of Pressor Amines in Phaeochromocytoma

Burn¹

1953

BMJ

View full text Add to dashboard Cite

“…Since then, attempts to investigate the sympathetic nervous system directly by studying UNE excretion in hypertensive patients or the plasma catecholamine concentration have failed to reveal consistent findings except in pheochromocytoma. 33 In previous Studies, urinary catecholamines have been found to be increased, 3 615 4 in patients with essential hypertension. These discrepancies may stem from differences in technique since many of the older studies relied on the less sensitive or specific bioassay and fluorometric methods.…”

mentioning

confidence: 87%

Norepinephrine in urine and plasma following provocative maneuvers in normal and hypertensive subjects.

Henry¹,

Luft²,

Weinberger³

et al. 1980

Hypertension

View full text Add to dashboard Cite

SUMMARY Urinary norepinephrine (UNE) excretion rate and venous plasma norepinephrine (PNE) concentrations were studied in 266 normotensive and 107 essential hypertensive men and women under conditions of volume expansion with 2 liters of intravenous normal saline over 4 hours, and volume contraction with a 10 mEq sodium diet and 120 mg oral furosemide. The UNE excretion rate was correlated with age in normal women only. In men, and in hypertensives of both sexes, the relationship appeared to be biphasic. The PNE concentration was not correlated with age in the hypertensive subjects. Insufficient numbers of older subjects were available to exclude absolutely such a relationship among normals. The UNE and PNE were influenced by volume expansion and contraction in both normals and hypertensives; however, normals exhibited a correlation between UNE and blood pressure as well as consistent correlations between UNE and PNE, neither of which were observed in the hypertensives. T HE sympathetic nervous system plays a major role in regulating the blood pressure of normal persons 1 and has also been implicated in the development of experimental hypertension, 2 and of certain forms of human essential hypertension. 36Norepinephrine concentrations in plasma (PNE) and urine (UNE) have been proposed as parameters of generalized sympathetic nervous system activity. 6 In the present report, we describe the effects of volume expansion and contraction on the rate of UNE excretion and venous PNE concentration in two large groups of men and women, one normal, the other with essential hypertension. Our results extend previous observations that age and sex exert important influences on UNE excretion.7 ' 8 The state of body fluid volume and posture influence both UNE and PNE.

show abstract

“…The estimation of urinary catecholamine output as a means of diagnosing pheochrome cell tumors was introduced several years ago. 26 It has since been used extensively as a simple and reliable method for this purpose. Epinephrine or norepinephrine figures near and above 100 p.g per 24 hours for the free amines are strongly indicative of such a tumor in connection with hypertension, especially in younger individuals.…”

Section: Catecholamine Production and Release In Man Measured By Plasmentioning

confidence: 99%