Diagnostic Value of Lipid Profile in Hemorrhagic Stroke Patients

Abstract

The relation between lipid profile and hemorrhagic stroke is controversial till now. Many epidemiological studies show inverse association of total cholesterol and triglycerides with hemorrhagic stroke. We analyze diagnostic role of lipid profile parameter in hemorrhagic stroke via case control study. The aim was to investigate lipid profile in hemorrhagic stroke patients and healthy control persons. Total 100 subject's case and control were included in this study and divided in two groups. 50 are hemorrhagic stroke patients and 50 are healthy control. Patients age <18, renal and hepatic impairment and familial hypercholesterolemia and hyperthyroidism were excluded. The inclusion of age group was between (64.8±11.9) and (48.9 ±9.9). Statistical analysis was done by using SPSS version 21.0. p value was calculated by ANOVA unpaired t-test. The p<0.05 was considered a statistically significant. The mean value of Total cholesterol (p=0.0001*) and Triglycerides (p=0.0254) were significantly low in hemorrhagic stroke patients compared with healthy control respectively. The mean LDL-C and VLDL-C were also significantly low in hemorrhagic stroke compared to healthy individuals (p=0.016 and p=0.025) respectively. Similarly, the mean HDL-C was also low in hemorrhagic stroke patients compare to healthy individuals. The hemorrhagic stroke patient's serum total cholesterol and triglycerides (r=-0.0854,p=0.0001 and r=-0.200 and p=0.046) were show significantly negative correlation with healthycontrol. The LDL-C and VLDL-C (r=-0.121 p=0.230 and r=-0.200, p=0.460) were show non-significant negative association in hemorrhagic stroke compare to healthy control respectively. HDL-C of hemorrhagic stroke patient's shows positively non-significantly associated with healthy control (r=0.0891, p=0.3785). This present study concluded that lipid profile levels play significant diagnostic role in hemorrhagic stroke patients. The lower concentration of total cholesterol and triglycerides may predispose individual towards the higher risk of hemorrhagic stroke.