Diagnostic value of lipids, total antioxidants, and trace metals in benign prostate hyperplasia and prostate cancer

Adedapo, Kayode Solomon; Arinola, OG; Ob, Shittu; Kareem, OI; Okolo, CA; Nwobi, LN

doi:10.4103/1119-3077.100623

Cited by 13 publications

(14 citation statements)

References 22 publications

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“…In 2009, Oluyemi et al, [32] reported a similar finding with individual antioxidants such as superoxide dismutase, catalase and vitamin E which was also supported by the observations made by Sosanya et al, (2014) [33]. Meanwhile, from an earlier study we suggested that the reason for which there was no significant difference in the level of total antioxidant status was probably because subjects took enough antioxidants that protected them from oxidative stress as at the period of study [34]. The report of this research however differ from the hypothesis advocated by Gago-Dominguez et al, (2005) [26] supporting a deficiency in lipid peroxidation and increased antioxidants as a procarcinogenic factor.…”

Section: Discussionsupporting

confidence: 70%

Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan

Adedapo

Olusanya

Takure

2015

Int Jour of Biomed Res

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A number of studies have investigated the roles of lipid peroxidation/ anti-oxidative balance as risk factors of prostate cancer. However, no study has yet to relate these factors with dietary habits of individuals in this environment. The objective of this study was to assess the role of lipid peroxidation and its relationship with vitamin D, calcium and dietary habits in individuals with prostate cancer. A total of sixty four (64) male participants (32 patients and 32 age-matched apparently healthy individuals as control) were recruited. Blood samples were analyzed for Malondialdehyde (MDA), Total antioxidant status (TAS), Calcium and Albumin spectrophotometrically; Prostate specific antigen (PSA) using immune radiometric assay; and Vitamin D by high performance liquid chromatography. Participants with prostate cancer had a significantly higher (p≤ 0.05) mean plasma level of MDA and PSA but lower TAS and vitamin D when compared with the control group. The plasma levels of MDA had a significant positive correlation with plasma PSA while negative with TAS in both groups. A significant proportion of the study participants that consumed dairy and smoked food regularly had a higher mean plasma level of MDA when compared with those that did not regularly as well as the control. This study has provided support for the hypothesis that lipid peroxidation and oxidative stress is associated with prostate cancer. A peculiar relationship exists between dairy and smoked food in prostate cancer which may be linked with increased lipid peroxidation.

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Section: Discussionsupporting

confidence: 70%

Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan

Adedapo

Olusanya

Takure

2015

Int Jour of Biomed Res

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“…Selenium intake may be low or might have been used up in the biochemical activity of glutathione peroxidase (GPx), which keeps at bay the generated free radicals to prevent oxidative stress recently implicated in prostate carcinogenesis. [30] This finding is consistent with a recent study by Adedapo et al, [31] on biochemical tie breaker between benign prostatic hyperplasia and prostate cancer subjects, selenium showed no significant difference between the two groups. Knekt et al [32] indicated no association between selenium level and prostate cancer risk.…”

Section: Resultssupporting

confidence: 91%

“…Our result was in consonance with the findings of Nomura et al that there was no clear association between serum -tocopherol level and prostate cancer risk in a nested case-control study of Japanese-American men. [22] This observation was also reported by Adedapo et al [31] stating no significant variation between -tocopherol and prostate cancer. However, it was noted from the literatures that significant difference was observed consistently among smokers where free radicals generated reduced antioxidant status in advanced prostate cancer.…”

Section: Resultssupporting

confidence: 78%

Plasma levels of α-tocopherol, -tocopherol and selenium in patients with prostate cancer in Nigeria

Famurewa¹,

Akinosun²

2014

Int J Med Biomed Res

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Background: Evidence suggests that essential trace metals and vitamins play crucial roles in slowing down the initiation and progression stages of many cancers, but the plausible role of selenium and vitamin E, especially the gamma-tocopherol ( -tocopherol), against prostate cancer is yet to be ascertained. Aim: To compare levels of selenium, alpha-tocopherol (α-tocopherol) and -tocopherol between prostate cancer (PCa) and benign prostatic hyperplasia (BPH) patients. Methods: Twenty (20) prostate cancer (PCa) patients and 25 patients with benign prostatic hyperplasia (BPH) recruited from Urology Clinic of the Department of Surgery, University College Hospital (UCH), Ibadan acted as case and control subjects, respectively. Informed consent was obtained from all participants. The plasma levels of selenium, α-tocopherol and -tocopherol were determined by Atomic Absorption Spectrophotometer (AAS) and High Performance Liquid Chromatography (HPLC), respectively. Results: -tocopherol levels were significantly higher in BPH patients (control) when compared with PCa patients. Selenium and -tocopherol levels were lower in PCa patients, but

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“…Of the five measured elements, a significant difference was noticed in the concentration of Se and Zn only between PCa and BPH groups. While higher levels of Fe and Cu have been reported in diet [14], studies noted an insignificant difference in the levels of these elements in prostatic tissue [10,12], blood [15] and hair [16] of PCa patients as [17] showed significantly lower Se levels in PCa and BPH both (vs. normal prostatic tissue) with more significant decrease in case of cancer. In contrast, Zachara et al [18] found significantly (p \ 0.01) higher Se level in PCa as compared to both healthy controls and benign prostate hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

Status and Interrelationship of Zinc, Copper, Iron, Calcium and Selenium in Prostate Cancer

et al. 2015

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Deficiency or excess of certain trace elements has been considered as risk factor for prostate cancer. This study was aimed to detect differential changes and mutual correlations of selected trace elements in prostate cancer tissue versus benign prostatic hyperplasia tissue. Zinc, copper, iron, calcium and selenium were analysed in histologically proven 15 prostate cancer tissues and 15 benign prostatic hyperplasia tissues using atomic absorption spectrophotometer. Unpaired two tailed t test/MannWhitney U test and Pearson correlation coefficient were used to compare the level of trace elements, elemental ratios and their interrelations. As compared to benign prostatic tissue, malignant prostatic tissue had significantly lower selenium (p = 0.038) and zinc (p = 0.043) concentrations, a lower zinc/iron ratio (p = 0.04) and positive correlation of selenium with zinc (r = 0.71, p = 0.02) and iron (r = 0.76, p = 0.009). Considerably divergent interrelationship of elements and elemental ratios in prostate cancer versus benign prostatic hyperplasia was noted. Understanding of differential elemental changes and their interdependence may be useful in defining the complex metabolic alterations in prostate carcinogenesis with potential for development of element based newer diagnostic, preventive and therapeutic strategies. Further studies may be needed to elucidate this complex relationship between trace elements and prostate carcinogenesis.

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Diagnostic value of lipids, total antioxidants, and trace metals in benign prostate hyperplasia and prostate cancer

Cited by 13 publications

References 22 publications

Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan

Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan

Plasma levels of α-tocopherol, -tocopherol and selenium in patients with prostate cancer in Nigeria

Status and Interrelationship of Zinc, Copper, Iron, Calcium and Selenium in Prostate Cancer

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