Status and Interrelationship of Zinc, Copper, Iron, Calcium and Selenium in Prostate Cancer

Singh, Bhupendra; Dwivedi, Shailendra; Dhakad, Urmila; Murthy, Ramesh; Choubey, Vimal Kumar; Goel, Apul; Sankhwar, Satya Narayan

doi:10.1007/s12291-015-0497-x

Cited by 30 publications

(17 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a scarcity of published data regarding the correlations of various bioelements in the serum of transplant recipients. In the study of Singh et al [26], Zn was found to have positive correlations with Se in prostate cancer [26], which corresponds with our results.…”

Section: Discussionsupporting

confidence: 92%

Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

Wilk

Szypulska-Koziarska

Marchelek-Myśliwiec

et al. 2020

Biol Trace Elem Res

View full text Add to dashboard Cite

There are data available in the literature on bioelement concentrations in the serum of various groups of patients; however, very little is known about the serum concentration of selenium (Se), iron (Fe), zinc (Zn), and copper (Cu) in renal transplant patients treated with immunosuppressive drugs, including mycophenolate mofetil (MMF). Monitoring of serum bioelement concentrations in renal transplant recipients is of profound importance, as the proper bioelement levels seem to prolong the normal function of the transplanted organ. Thus, the aim of this current study was to examine and carry out comparative analysis involving serum concentrations of Se, Fe, Cu, and Zn of renal transplant recipients treated with MMF and without MMF. The material consisted of blood samples from 115 patients of the the city of Szczecin in the northwestern Poland. Serum Se, Fe, Cu, and Zn levels were quantified by inductively coupled mass spectroscopy (ICP-MS). Taking into account all patients, MMF increases Cu level. Cu and Fe concentrations were significantly higher in women treated with MMF; in group of younger patients treated with MMF, Se level was significantly lower comparing with those whose regimen did not include MMF. Additionally, MMF in combination with prednisone increased Se concentration in blood of transplant recipients. Our study highlights that trace elements should be monitored to allow for an early detection of trace elements deficits, which can easily be corrected for by an adjusted diet or supplemental intake.

show abstract

Section: Discussionsupporting

confidence: 92%

Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

Wilk

Szypulska-Koziarska

Marchelek-Myśliwiec

et al. 2020

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Some studies indicate that selenium deficiency may also play a significant role in the etiology of prostate cancer [37]. However, the function of selenium in the prostate has not as yet been specified.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Zinc and Selenium Supplementation Mode on Their Bioavailability in the Rat Prostate. Should Administration Be Joint or Separate?

et al. 2016

View full text Add to dashboard Cite

It is thought that zinc and selenium deficiency may play a significant role in the etiology of prostate cancer. Although joint zinc and selenium supplementation is frequently applied in the prevention of prostate diseases, the bioavailability of these elements in the prostate after co-administration is still unknown. The study examines the effect of subchronic supplementation of zinc gluconate and selenium compounds (sodium selenite or selenomethionine), administered together or separately, on their bioavailability in the prostate, as well as the induction of metallothionein-like proteins (MTs) bound to zinc in the prostate and liver. Zinc concentration in the dorso-lateral lobe of the prostate was significantly elevated already after the first month of supplementation of zinc alone. In the supplementation period, the MTs level increased together with zinc concentration. In contrast, the ventral lobe of the prostate did not demonstrate significantly higher levels of zinc until after three months of supplementation, despite the MTs induction noted after one-month supplementation. Increased selenium levels in the dorsolateral lobe were observed throughout the administration and post-administration periods, regardless of the selenium compound used or whether zinc was co-administered. The results of our studies suggested for the first time that these elements should not be administered jointly in supplementation.

show abstract

“…The most common techniques used today for the quantification of Cu and Fe from biological samples in vitro and ex vivo include inductive coupling plasma mass spectrometry (ICP-MS) [209][210][211][212], atomic absorption spectrometry (AAS) [212,213], total reflection X-ray fluorescence (TXRF) [214,215], and colorimetric assays by UV-Vis measurements [216,217]. ICP-MS is a highly sensitive tool that allows the precise quantification of metal content down to sub parts per billion (ppb) levels using internal standards [218,219].…”

Section: Techniques To Quantify Cu and Fe Levelsmentioning

confidence: 99%

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

et al. 2018

View full text Add to dashboard Cite

A very promising direction in the development of anticancer drugs is inhibiting the molecular pathways that keep cancer cells alive and able to metastasize. Copper and iron are two essential metals that play significant roles in the rapid proliferation of cancer cells and several chelators have been studied to suppress the bioavailability of these metals in the cells. This review discusses the major contributions that Cu and Fe play in the progression and spreading of cancer and evaluates select Cu and Fe chelators that demonstrate great promise as anticancer drugs. Efforts to improve the cellular delivery, efficacy, and tumor responsiveness of these chelators are also presented including a transmetallation strategy for dual targeting of Cu and Fe. To elucidate the effectiveness and specificity of Cu and Fe chelators for treating cancer, analytical tools are described for measuring Cu and Fe levels and for tracking the metals in cells, tissue, and the body.

show abstract

Status and Interrelationship of Zinc, Copper, Iron, Calcium and Selenium in Prostate Cancer

Cited by 30 publications

References 37 publications

Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

The Effect of Zinc and Selenium Supplementation Mode on Their Bioavailability in the Rat Prostate. Should Administration Be Joint or Separate?

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

Contact Info

Product

Resources

About