Diagnostic value of neutrophil CD64 combined with CRP for neonatal sepsis: A meta-analysis

Song, Yan; Chen, Yuanchun; Xue, Dong; Jiang, Xiaohua

doi:10.1016/j.ajem.2019.05.001

Cited by 22 publications

(9 citation statements)

References 34 publications

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“…CRP has been effectively used to diagnose sepsis initially, but its specificity decreases further later in the course as a result of chronically high levels [22] . CRP levels were considerably higher in sepsis caused by gram-negative bacterial infections than in sepsis caused by gram-positive infections, indicating a distinct immunomodulatory response [23] .…”

Section: Discussionmentioning

confidence: 92%

Study of Soluble Intercellular Adhesion Molecule-1 in Patients with Sepsis in Medical Intensive Care Unit, Zagazig University Hospitals and its Relation to the Clinical Outcome

Khalil¹,

Nour²,

Abdel-hamed³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Intercellular Adhesion Molecule-1 (ICAM-1), which mediates cell-cell adhesion to the extracellular matrix, may be released in cascades throughout sepsis, causing serious damage to vascular endothelial cells. Numerous investigations have demonstrated that it is elevated in individuals with sepsis. Thus, ICAM-1 may be a useful biomarker in predicting and diagnosing sepsis. Objectives: The aim of the current work was to measure serum sICAM-1 level in septic ICU patients to determine the association between serum sICAM-1 and inflammatory response of sepsis, clinical severity and mortality. Patients and Methods: A Cohort study was conducted on 40 critically ill patients with sepsis and admitted to the intensive care unit in the Internal Medicine Hospital, Zagazig University Hospitals. Results: There was a high significant increase of SICAM-1 level in septic patients with MOF group compared to patients without MOF (p=0.003). A significant increase of serum ICAM-1 level in the non-survivors group compared to the survivor's group (p<0.001). Serum ICAM-1 had a significant positive correlation with age, APACHE II, SOFA score, TLC, ESR, CRP, urea and creatinine. There was no correlation between serum ICAM-1 with each sex, AST and ALT. Using multivariate regression analysis, it was found that serum sICAM-1 level is an independent factor for predicting the severity. Serum ICAM-1level at 232.4 ng/ml had a sensitivity of 100%, specificity of 100%, 100% NPV and 100% PPV in detecting the clinical Outcome of septic patients in ICU. Conclusions: It could be concluded that the increased serum level of sICAM-1 in septic ICU patients is associated with inflammatory response and organ damage and may predict their clinical Outcome during their admissions in ICU.

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Section: Discussionmentioning

confidence: 92%

Study of Soluble Intercellular Adhesion Molecule-1 in Patients with Sepsis in Medical Intensive Care Unit, Zagazig University Hospitals and its Relation to the Clinical Outcome

Khalil¹,

Nour²,

Abdel-hamed³

et al. 2022

The Egyptian Journal of Hospital Medicine

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“…Given the biological complexity of sepsis, a strategy based on a panel of multiple biomarkers is likely to have more potential to meet the needs of an ideal diagnostic test than any single biomarker [2]. Thus, using combinations of previously identified biomarkers has been recently investigated to improve diagnosis accuracy [100][101][102][103]. For example, a recent meta-analysis concluded that the combined application of CRP and CD64 improved the accuracy of neonatal sepsis diagnosis [102].…”

Section: Emerging Research Into Diagnostic Biomarkers Of Sepsismentioning

confidence: 99%

“…Thus, using combinations of previously identified biomarkers has been recently investigated to improve diagnosis accuracy [100][101][102][103]. For example, a recent meta-analysis concluded that the combined application of CRP and CD64 improved the accuracy of neonatal sepsis diagnosis [102]. Combining a panel of biomarkers together with clinical information may prove even more accurate [90,104].…”

Section: Emerging Research Into Diagnostic Biomarkers Of Sepsismentioning

confidence: 99%

Host Diagnostic Biomarkers of Infection in the ICU: Where Are We and Where Are We Going?

Heffernan

Denny

2021

Curr Infect Dis Rep

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Purpose of Review Early identification of infection in the critically ill patient and initiation of appropriate treatment is key to reducing morbidity and mortality. On the other hand, the indiscriminate use of antimicrobials leads to harms, many of which may be exaggerated in the critically ill population. The current method of diagnosing infection in the intensive care unit relies heavily on clinical gestalt; however, this approach is plagued by biases. Therefore, a reliable, independent biomarker holds promise in the accurate determination of infection. We discuss currently used host biomarkers used in the intensive care unit and review new and emerging approaches to biomarker discovery. Recent Findings White cell count (including total white cell count, left shift, and the neutrophil-leucocyte ratio), C-reactive protein, and procalcitonin are the most common host diagnostic biomarkers for sepsis used in current clinical practice. However, their utility in the initial diagnosis of infection, and their role in the subsequent decision to commence treatment, remains limited. Novel approaches to biomarker discovery that are currently being investigated include combination biomarkers, host ‘sepsis signatures’ based on differential gene expression, site-specific biomarkers, biomechanical assays, and incorporation of new and pre-existing host biomarkers into machine learning algorithms. Summary To date, no single reliable independent biomarker of infection exists. Whilst new approaches to biomarker discovery hold promise, their clinical utility may be limited if previous mistakes that have afflicted sepsis biomarker research continue to be repeated.

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“…However, due to factors such as insufficient samples, maternal use of antibiotics, and antibiotic use before sampling, this method may give false negative results [4,5]. Various biomarkers, including C-reactive protein (CRP), procalcitonin (PCT), neutrophil CD64, interleukin-8, and interleukin-27, are used for sepsis diagnosis [6][7][8][9][10][11]. However, these biomarkers may also be elevated in noninfectious conditions such as premature rupture of membranes, fetal distress, dystocia, and perinatal asphyxia, resulting in false positive results and low specificity for neonatal sepsis [6].…”

Section: Introductionmentioning

confidence: 99%

The Accuracy of 16S rRNA Polymerase Chain Reaction for the Diagnosis of Neonatal Sepsis: A Meta‐Analysis

Wang

Zhao²,

Yao

et al. 2021

BioMed Research International

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Objective. To determine the accuracy of 16S rRNA polymerase chain reaction (PCR) for the diagnosis of neonatal sepsis through a systematic review and meta-analysis. Methods. Studies involving 16S rRNA PCR tests for the diagnosis of neonatal sepsis were searched in the PubMed, Medline, Embase, and Cochrane Library databases. The methodological quality of the identified studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2), and the sensitivity, the specificity, the positive likelihood ratio (PLR), the negative likelihood ratio (NLR), the diagnostic odds ratio (DOR), and the area under the curve (AUC) of operator characteristic (SROC) curves were determined. Heterogeneity between studies was analyzed by metaregression. Stata 14.0 and Meta-disc 1.4 software were used for the analyses. Results. This meta-analysis included 19 related studies. The analysis found a sensitivity of 0.98 (95% CI: 0.85-1), specificity of 0.94 (95% CI: 0.87-0.97), PLR of 16.0 (95% CI: 7.6-33.9), NLR of 0.02 (95% CI: 0.00-0.18), DOR of 674 (95% CI: 89-5100), and AUC of 0.99 (95% CI: 0.97-0.99). Metaregression analysis identified Asian countries, arterial blood in blood samples, and sample size > 200 as the main sources of heterogeneity. This meta-analysis did not uncover publication bias. Sensitivity analysis showed that the study was robust. Fagan’s nomogram results showed clinical usability. Conclusions. The results from this meta-analysis indicate that 16S rRNA PCR testing is effective for the rapid diagnosis of neonatal sepsis.

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Diagnostic value of neutrophil CD64 combined with CRP for neonatal sepsis: A meta-analysis

Cited by 22 publications

References 34 publications

Study of Soluble Intercellular Adhesion Molecule-1 in Patients with Sepsis in Medical Intensive Care Unit, Zagazig University Hospitals and its Relation to the Clinical Outcome

Study of Soluble Intercellular Adhesion Molecule-1 in Patients with Sepsis in Medical Intensive Care Unit, Zagazig University Hospitals and its Relation to the Clinical Outcome

Host Diagnostic Biomarkers of Infection in the ICU: Where Are We and Where Are We Going?

The Accuracy of 16S rRNA Polymerase Chain Reaction for the Diagnosis of Neonatal Sepsis: A Meta‐Analysis

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