Diagnostic Value of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume on Early Onset Neonatal Sepsis on Term Neonate

Karabulut, Birol; Alataş, Şilem Özdem

doi:10.1055/s-0040-1715104

“…But only one study investigated the CRP/MPV ratio in children with pneumonia [28]. Various other ratios are being used in the diagnosis of neonatal sepsis, which includes CRP/albumin ratio [29], neutrophil-lymphocyte ratio [15,[30][31][32][33], and platelet to lymphocyte ratio [34].…”

Section: Introductionmentioning

confidence: 99%

Salivary and Serum Interleukin-10, C-Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late-Onset Neonatal Sepsis in Full-Term Neonates

Omran

¹

,

Sobh

²

,

Abdalla

³

et al. 2021

Journal of Immunology Research

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Salivary markers could serve as potential noninvasive markers in the diagnosis of neonatal infections. We aimed to investigate the diagnostic role of salivary and serum interleukin 10 (IL-10), C-reactive protein (CRP), mean platelet volume (MPV), and CRP/MPV ratio in the diagnosis of late-onset neonatal sepsis in full-term neonates. Seventy full-term neonates were enrolled in this prospective case-control study, 35 with late-onset neonatal sepsis, and 35 controls. Salivary IL-10, serum IL-10, and CRP concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Complete blood (CBC) count was measured by an automated blood cell counter. The salivary IL-10, serum IL-10, CRP, MPV, and CRP/MPV ratio levels were much higher in neonates with late-onset sepsis than in control ( 220 ± 150 vs. 18 ± 9 pg / ml , P < 0.001 ), ( 316 ± 198 vs. 23.7 ± 14 pg / ml , P < 0.001 ), ( 78.2 ± 34 vs. 3.3 ± 1.7 mg / L , P < 0.001 ), ( 11.2 ± 0.9 vs. 8.6 ± 0.4 fL ), and ( 7.08 ± 3.3 vs. 0.4 ± 0.2 , P < 0.001 ), respectively. At the cutoff point of >31 pg/ml, salivary IL-10 showed 97.1% sensitivity and 94.3% specificity. Serum IL-10 at a cutoff value of ≥33.6 pg/ml had a sensitivity of 97.1% and specificity of 80%. MPV showed a sensitivity of 100% and specificity of 94.4% at a cutoff value ≥ 9.2 fL . CRP/MPV ratio showed a sensitivity of 100% and specificity of 97.1% at a cutoff value > 0.9 . Salivary and serum IL-10 showed a positive correlation with CRP and CRP/MPV ratio in septic neonates. The current study shows for the first time that both salivary IL-10 and CRP/MPV showed statistically significant differences between neonates with late-onset sepsis and controls. Accordingly, salivary IL-10 could serve as a potential noninvasive biomarker for the diagnosis of late-onset sepsis in full-term neonates.

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“…Septic preterm neonates had considerably greater NLR than full-term and preterm controls, with a value of 3.4. Some research came to the same conclusion: septic neonates had higher levels of neutrophils and NLR than controls, which was statistically significant [15,9].…”

Section: Discussionmentioning

confidence: 88%

“…An study conducted by Karabulut and Alatas found that variations in gestational age, birth weight, and delivery method might account for the broad cutoff values, sensitivity, and specificity of traditional indicators routinely employed in newborn sepsis diagnosis [15].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Neutrophil to Lymphocyte Ratio on Neonatal Sepsis in Full Term and Preterm Neonates

Nady

¹

,

Ismaiel

²

,

Assar

³

2021

Benha Journal of Applied Sciences

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Background: Sepsis is a life-threatening illness with notably high degree of mortality both in preterm and term neonates. Roughly, it may be characterized as a systemic inflammatory response that occurs as a consequence of confirmed or suspected infection in neonatal period. Especially in underdeveloped countries, early detection and treatment of newborns with infections are inadequate. Clinical findings of sepsis in newborns are problematic since many of the symptoms associated to sepsis are unclear and they might be revealed with conditions of other noninfectious disorders. Neonatal sepsis remained a serious concern for neonates across the globe and generates considerable morbidity and death neonates (term and preterm), particularly in underdeveloped nations. It was a clinical illness that defined by systemic infections and characterized by the isolation of bacteria in the blood (bacteremia) that occurs in babies in the first month of life. The cornerstone underlying the development of newborn sepsis is inflammation. Common measures utilized for the effective diagnosis and treatment of newborn sepsis, apart for blood cultures, comprise of inflame inflammatory indicators. Accordingly, the study of inflammatory biomarkers is an essential element of sepsis research. In particular, the influence of inflammation on blood cells such as neutrophils, lymphocytes, and platelets has been a focus of study on the diagnosis of sepsis. The purpose of the study was to establish value of neutrophil to lymphocyte ratio in diagnosis of newborn sepsis in full term and preterm neonates. Methods: This was a prospective research was done at neonatal intensive care unit of Benha university hospital; 120 neonates who were split into 2 groups: Group I (patient) :include 60 septic neonates who were separated into 2 subgroups: Group I (A) : 30 full term newborns and Group I (B) : 30 preterm neonates, whereas Group II (control) :include 60 healthy neonates who were broken into 2 subgroups: Group II (A) : 30 full term newborns and Group II (B) : 30 preterm neonates. Results: In this research, hemorrhage and fever were considerably greater in pre-term septic neonates than full term and pre-term controls. PROM and UTI were considerably greater in full term septic neonates than full term and pre-term controls. In addition, they were substantially greater in pre-term septic neonates than full term and pre-term controls. In the current investigation, the most prevalent organism was Klebsiella (33.3 percent ), followed by E.coli (23.3 percent ), pseudomonas (16.7 percent ), staph aureus (15.0 percent ), Group B streptococcus (6.7 percent ), and strept pneumonia (5.0 percent ). (5.0 percent ). CRP indicated an overall significant difference between research groups (P-value <0.001). Post hoc analysis found that it was considerably higher in full-term septic neonates (24) compared to full-term controls (2.3) and preterm controls (1.8). (1.8). Also, CRP in preterm septic newborns was substantially higher (24) than full-term and preterm controls. In ...

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“…For instance, higher CRP levels were reported to be associated with post-septal disease in a recent study [10]. NLR is a parameter which is studied in bacterial infections such as neonatal sepsis, urinary tract infection and community acquired pneumonia [13][14][15]. A recent study which included 243 children with orbital infections, of whom 51 (20.6%) had OC, found that an NLR value of > 3.14 could differentiate OC from PC with a sensitivity of 75.5% and a speci city of 77.4% [16].…”

Section: Discussionmentioning

confidence: 99%

Preseptal and Orbital Cellulitis: Thirteen Years of Experience and a Novel Scoring System (SNIPPED Score) for Differentiation

Yalçınkaya

¹

,

Tanır

²

,

Özdem

³

et al. 2021

Preprint

0

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We aimed to evaluate clinical and laboratory characteristics of children with preseptal cellulitis (PC) or orbital cellulitis (OC) and to determine whether easily-accessible parameters could be used to predict OC. The data of children diagnosed with PC or OC between January 2008 and December 2020 were evaluated. Patients aged between 1 month and 18 years who were treated with intravenous antibiotics were included. Logistic regression analysis was performed to identify possible parameters in differentiating between PC and OC. A beta coefficient-based method was used to derive the scoring system. A total of 375 patients [202 (53.9%) boys], of whom 35 (9.3%) had OC, were evaluated. Median age was 44 (min-max: 1-192) months. Compared to those with PC, patients with OC were older (p = 0.001), had fever and upper respiratory tract infection (URTI) symptoms more frequently, and demonstrated prolonged symptom and hospitalization times (p˂0.001 for all). Significant differences between groups were observed for numerous parameters; however, logistic regression analysis revealed only five parameters independently associated with OC. The SNIPPED score variables and weights were as follows: sinusitis (2 points), neutrophil-to-lymphocyte ratio > 6.78 (3 points), platelet count > 420.5 x103/mm3 (2 points), proptosis (4 points) and duration of symptoms ≥ 4 days (4 points). A cut-off of ≥ 7 points for OC diagnosis was found to have 91.4% sensitivity, 96.2% specificity, 71.1% PPV, 99.1% NPV and 95.7% accuracy. Conclusion: In addition to showing previously known properties of OC versus PC, our study demonstrated that easily-accessible parameters could be used for the identification of OC.

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Diagnostic Value of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume on Early Onset Neonatal Sepsis on Term Neonate

Cited by 19 publications

References 28 publications

Salivary and Serum Interleukin-10, C-Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late-Onset Neonatal Sepsis in Full-Term Neonates

Salivary and Serum Interleukin-10, C-Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late-Onset Neonatal Sepsis in Full-Term Neonates

Diagnostic Value of Neutrophil to Lymphocyte Ratio on Neonatal Sepsis in Full Term and Preterm Neonates

Preseptal and Orbital Cellulitis: Thirteen Years of Experience and a Novel Scoring System (SNIPPED Score) for Differentiation

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