Diagnostic value of serum CA125, CA19-9 and CA15-3 in endometriosis: A meta-analysis

Airong, Shen; Xu, Shengnan; Ma, Yange; Guo, Huanhuan; Li, Canyu; Yang, Cui; Zou, Shunhong

doi:10.1177/0300060515583076

Cited by 33 publications

(31 citation statements)

References 31 publications

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“…We conducted a comprehensive search strategy, robust methodology, and statistical analysis. Previously published systematic reviews, are out of date or associated with methodological bias arising from case‐control studies and verification bias arising from the reliance upon visual inspection, which is now known to be inaccurate . All studies included in this study reported the primary endpoint using the reference standard of histologically confirmed endometriosis.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Hirsch

Duffy

Davis

et al. 2016

BJOG

110

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Section: Discussionmentioning

confidence: 99%

“…Individual studies have methodological limitations in patient selection, poor conduct of the index test, and poor conduct of the reference test . Two diagnostic reviews exist; however, the first is over 15 years old and includes studies with high risk of verification bias and the second is of poor methodological quality …”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Hirsch

Duffy

Davis

et al. 2016

BJOG

110

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“…The weak correlation between Ca125 and vaginal swab culture can be explained by bacterial-induced inflammation process of gynaecology organs. 14,15 This study showed that peritoneal fluid culture had significant inverse correlation with left tubal patency. This might be due to different vascularisation and pelvic anatomy, in which pathologic symptoms are also found more common in the left side.…”

Section: Discussionmentioning

confidence: 75%

Identification of microorganisms in vaginal swab and peritoneal fluid of women with endometriosis

Hadisaputra¹,

Judio²,

Gunardi³

2018

Indones J Obstet Gynecol

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Abstract Objective: to discover correlation between microorganisms found in vaginal swab culture and in peritoneal fluid culture from laparoscopy in reproductive age women diagnosed with endometriosis. Methods: This cross sectional study was conducted in Bunda Hospital and YPK Hospital, Central Jakarta. Thirty one subjects was includedby consecutive sampling. Data were analyzed using SPSS 20.0 for Windows. Bivariate analysis was used to identify the correlation between independent and dependent variable. Results: From 31 subjects with mean age 34.42+5.056 years old, 87.1% were infertile. Vaginal swab culture was found positive in 83.9% subjects while peritoneal fluid culture was found positive only in 9.6% subjects. There was moderate correlation between chronic pelvic pain and positive vaginal swab culture (r=0.601; p=0.001), but weak correlation between Ca125 and vaginal swab culture (r=0.440; p=0.010). Peritoneal fluid culture had significant inverse correlation with left tubal patency (r=-0.346; p=0.047). There was weak correlation between vaginal swab culture and peritoneum fluid culture with correlation coefficient of 0.13. Conclusion: Most of bacteria found in vaginal swab culture and peritoneal fluid culture were the ones found in gastrointestinal tract. However, vaginal swab and peritoneal fluid culture were not sufficient to prove the hypothesis that infection has a role in pathogenesis of endometriosis. Therefore, advance and more complete examination such as LPS and PCR might be needed to be done in the future research with cohort study, to overcome the limitation of this study. Keywords: endometriosis, ascending bacterial contamination, vaginal swab, peritoneal fluid, culture Abstrak Tujuan : Membuktikan adanya korelasi antara mikroorganisme yang ditemukan pada hasil kultur bilasan vagina dengan mikroorganisme yang ditemukan pada cairan peritoneum hasil laparoskopi perempuan usia reproduksi yang terdiagnosis endometriosis Metode :Penelitian ini menggunakan desain penelitian analitik poltong lintang yang bertujuan untuk melihat adanya hubungan korelasi serta mengetahui tingkat korelasi antara mikroorganisme kultur bilasan vagina dengan mikroorganisme pada cairan peritoneum pasien endometriosis. Hasil: Hasil kultur bilasan vagina dari 31 subjek penelitian yang diteliti, mikroorganisme terbanyak adalah Enterococcus faecalis (32.3%), Eschericia coli (29.1%), dengan 16.1 % dengan hasil kultur negatif. Sedangkan dari hasil kultur bilasan peritoneum terdapat 3 subjek (9.6%) dengan hasil positif yaitu dengan jenis bakteri Eschericia coli, Enterococcus faecalis, dan Pseudomonas. Terdapat korelasi lemah antara hasil kultur bilasan vagina dengan kultur bilasan peritoneum (r 0.13). Terdapat korelasi sedang antara kultur positif bilasan vagina dengan nyeri pelvik kronis, korelasi lemah antara kultur positif bilasan vagina dengan nilai Ca 125, dan korelasi lemah antara kultur positif cairan peritoneum dengan tuba kiri yang non paten. Kesimpulan: Sebagian besar bakteri dari bilasan vagina dan bilasan peritoneum pada pasien endometriosis memiliki hasil bakteri dari organ pencernaan. Terdapat korelasi lemah antara hasil kultur bilasan vagina dengan kultur bilasan peritoneum pada pasien endometriosis. Kata kunci: endometriosis, kontaminasi bakteri asenden, kultur, bilasan vagina, cairan peritoneum

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“…Endometriosis is significantly associated with elevated serum CA 125 and CA 19-9 concentrations, and CA 19-9 is increased further in the more advanced stages of disease. Serum CA 125 and CA 19-9 may represent useful biomarkers for the noninvasive diagnosis of endometriosis [ 21 22 23 ]. This relation could be explained that the patients with increased risk of recurrence might accept uncritically the post-operative medical treatment for prevention [ 24 25 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical experience of long-term use of dienogest after surgery for ovarian endometrioma

et al. 2018

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ObjectiveEndometriosis is a common and recurring gynecologic disease which have afflicting females of reproductive age. We investigated the efficacy of long-term, post-operative use of dienogest for ovarian endometrioma.MethodsWe studied 203 patients who had undergone laparoscopic or robotic surgery for ovarian endometrioma, and were administrated dienogest 2 mg/day beginning in July of 2013, and continuing. We evaluated side effects of dienogest and ultrasonography was performed every 6 months to detect potential recurrence of endometrioma (2 cm) in these post-surgical patients.ResultsThe follow-up observation periods were 30.2±20.9 months from surgery. The mean age was 34.1±7.2 years old. The mean diameter of pre-operative endometrioma was 5.6±3.0 cm2. One hundred eighty-two (89.7%) women received dienogest continuously for 12.0±7.1 months. Of the subjects, 21 (10.3%) patients discontinued dienogest at 2.4±1.0 months. The most common side effect when dienogest was discontinued was abnormal uterine bleeding. The occurrence rate of vaginal bleeding was 15.8%, a number which did not differ significantly in patients with/without post-operative gonadotropin releasing hormone agonist administration. The other side effects were gastrointestinal trouble including constipation, acne, headache, depression, hot flush, weight gain, and edema. However, no serious adverse events or side effects were documented and recurrent endometriomas were diagnosed in 3 patients (1.5%).ConclusionThe data indicates that dienogest was both tolerable and safe for long-term use as prophylaxis in an effort to obviate the recurrence of ovarian endometrioma post-operatively, as well as potential need for surgical re-intervention.

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Diagnostic value of serum CA125, CA19-9 and CA15-3 in endometriosis: A meta-analysis

Cited by 33 publications

References 31 publications

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Identification of microorganisms in vaginal swab and peritoneal fluid of women with endometriosis

Clinical experience of long-term use of dienogest after surgery for ovarian endometrioma

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