Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer

Wang, Yaping; Zhu, Zhiyong; Liu, Zhilan; Zhao, Zhen; Xue, Xiangdong; Li, Xiaolin; Li, Pingying; Rong, Guanghong; Ma, Yussanne

doi:10.1177/0300060520914826

Cited by 24 publications

(16 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PG is almost exclusively secreted by the stomach, and the secretion amount will also change during the secretion stage. Therefore, PG subgroups can reflect the changes in the number of gastric mucosal glands and cells, as well as the secretory function of different mucosal sites (15,16). When the gastric mucosa is atrophic, the number of gastric corpus glands and fundus glands decrease due to the replacement of the pyloric glands, followed by the decrease of principal cells.…”

Section: Discussionmentioning

confidence: 99%

Application of serum pepsinogen and carbohydrate antigen 72-4 (CA72-4) combined with gastrin-17 (G-17) detection in the screening, diagnosis, and evaluation of early gastric cancer

Lin¹,

Bian²,

Chen³

et al. 2021

J Gastrointest Oncol

View full text Add to dashboard Cite

Background: Gastric cancer is a common malignant tumor. The aim of the present study was to analyze the application value of serum pepsinogen (PG), carbohydrate antigen 72-4 (CA72-4), and gastrin-17 (G-17) detection in the screening, diagnosis, and evaluation of early gastric cancer.Methods: In total, 122 patients with gastric cancer treated in our hospital from January 2018 to January 2021 were selected as the gastric cancer group and subdivided into the early gastric cancer (group A) and advanced gastric cancer (group B) groups. Sixty-five patients with benign gastric disease treated in the same hospital during the same period were selected as the control group, and 122 healthy people who underwent physical examination during the same period were allocated to the control group. The differences in the levels of G-17, PGI, PGII, PGI/PGII, and CA72-4 were compared; receiver-operating characteristic curves were drawn; and the efficacy of different factors in the diagnosis of early gastric cancer was calculated.Results: G-17, PGI, and PGI/PGII levels in the gastric cancer group were significantly lower than those in the healthy group, and CA72-4 was significantly higher than that in the healthy group (P<0.05), but there was no significant difference in PGII between the 2 groups (P>0.05). G-17, PGI, and PGI/PGII levels in groups A and B were significantly lower than those in the control group. CA72-4 in groups A and B was significantly higher than that of the control group, and was highest in group B (P<0.05). The areas under the curve (AUC) of G-17, PGI, PGI/PGII, and CA72-4 were 0.671, 0.726, 0.769, and 0.602, respectively, and the AUC of combined detection was 0.883, which was significantly higher than that of single detection.Conclusions: Serum PG, CA72-4 combined with G-17 detection has high sensitivity and specificity in the screening and diagnosis of early gastric cancer, and has high clinical application value.

show abstract

Section: Discussionmentioning

confidence: 99%

Application of serum pepsinogen and carbohydrate antigen 72-4 (CA72-4) combined with gastrin-17 (G-17) detection in the screening, diagnosis, and evaluation of early gastric cancer

Lin¹,

Bian²,

Chen³

et al. 2021

J Gastrointest Oncol

View full text Add to dashboard Cite

show abstract

“…In order to assess the value of gastrin in the diagnosis of GC, Tu et al and Wang et al conducted cohort studies using the method of epidemiology survey. 17 , 18 Although they got the data of diagnostic accuracy, the reliability is relatively low because of the method and very few GC patients. 17 , 18 In our studies, we found that the positive rate of gastrin-17 was 22.61% in GC, but the sensitivity of gastrin-17 could reach to 71.30% (95% CI: 65.00–77.10%) for diagnosing GC after using an optimal cutoff value.…”

Section: Discussionmentioning

confidence: 99%

“…15 , 16 Although Tu et al and Wang et al evaluated the diagnostic value of gastrin-17 for GC, they mainly aimed to assess the association between gastrin-17 and GC by using the method of epidemiology survey, not a diagnostic test. 17 , 18 Therefore, the effect of gastrin in the diagnosis of GC should be clarified further.…”

Section: Introductionmentioning

confidence: 99%

Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer

Wang¹,

Mo²,

Tian³

et al. 2021

IJGM

View full text Add to dashboard Cite

“…Gastrin is a gastrointestinal hormone secreted by gastric antrum G cells, and its level is mainly affected by the number and function of G cells, as well as by the negative feedback regulation of gastric acid [7] . As a gastrointestinal hormone, G17 can not only maintain the integrity of digestive tract structure, but also regulate the function of digestive tract.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Results of Gastrin-17 and its Related Influencing Factors in Health Check-Up Population

Shen¹,

Zeng²,

San-ping³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: To analyze the difference of serum gastrin-17 levels in different sexs, ages, and body mass index (BMI) of healthy people, and to explore the correlation between gastrin 17 and pepsinogen, in addition to study the influence of Helicobacter pylori infection and various inflammatory factors on the secretion level of gastrin-17. Methods: 531 subjects who received physical examination in our center from April 2019 to December 2019 were enrolled in the study. All the staff were tested for gastrin 17 (G17), pepsinogen I (PGI), pepsinogen II (PGII), PGI / PGII (PGR), Helicobacter pylori (Hp) and C-reactive protein (CRP) and other inflammatory factors. To compare the difference of G17 secretion in different populations and its correlation with PG, then to understand the HP infection and the influence of inflammatory indicators on G17. Results: There was no significant difference in the secretion level of G17 in different sex, age and BMI (P > 0.05); G17 was positively correlated with PGI and PGII, but negatively correlated with PGR; the level of G17 in Helicobacter pylori positive patients was 10.16±12.84, which was significantly higher than that in negative patients(3.27±6.65), P =0.017, 95% CI: 1.713 (1.100, 2.668); the increase of serum amyloid A(SAA) in different inflammatory indicators was the high-risk factor of G17 abnormality, P=0.016, 95% CI: 2.692 (1.202, 6.028), obviously CRP and erythrocyte sedimentation rate (ESR) had no effect on G17 abnormalities. Conclusions: The secretion of G17 is closely related to PG and HP. Combined screening is helpful for early screening of gastrointestinal diseases in healthy or high-risk groups of gastric cancer, but the influence of inflammatory indicators on G17 should be excluded to improve the reliability of the results.

show abstract

Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer

Cited by 24 publications

References 13 publications

Application of serum pepsinogen and carbohydrate antigen 72-4 (CA72-4) combined with gastrin-17 (G-17) detection in the screening, diagnosis, and evaluation of early gastric cancer

Application of serum pepsinogen and carbohydrate antigen 72-4 (CA72-4) combined with gastrin-17 (G-17) detection in the screening, diagnosis, and evaluation of early gastric cancer

Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer

Analysis of the Results of Gastrin-17 and its Related Influencing Factors in Health Check-Up Population

Contact Info

Product

Resources

About