Diagnostic Value of Sestrin2 in Patients with Obstructive Sleep Apnea

Abstract

Background: Obstructive sleep apnea (OSA) is a serious threat to individual health. Diagnosis of OSA is mainly polysomnography (PSG). However, PSG monitoring is costly and time-consuming. At present, increasing studies are exploring new diagnostic methods for OSA. This study aimed to explore the diagnostic role of Sestrin2 in OSA. Materials and Methods: Sixty-four subjects were recruited in this study. The concentration of plasma Sestrin2 of all subjects were measured and compared. Spearman's correlation analysis was used to investigate the correlation between plasma Sestrin2 concentration and other factors. Receiver-operating characteristic (ROC) curve was used to investigate the role of Sestrin2 in the diagnosis of OSA, moderate-severe and severe OSA. Results: Subjects were divided into OSA group ( n = 38) and control ( n = 26). Levels of Plasma Sestrin2 were significantly higher in OSA patients than in controls. Sestrin2 was positively correlated with oxygen reduction index and negatively correlated with mean oxygen saturation and lowest oxygen saturation. The area under ROC curve (AUC) of Sestrin2 for OSA diagnosis was 0.740 [95% confidence interval (CI), 0.615–0.842], the cutoff value was 1.86 ng/mL, and the sensitivity and specificity were 81.58% and 61.54%, respectively. The AUC of Sestrin2 for the diagnosis of severe OSA was 0.801 (95% CI, 0.682–0.890), and the cutoff value was 5.21 ng/mL exhibiting the sensitivity and specificity of 61.90% and 90.70%, respectively. Conclusion: Setrin2 is a marker for OSA and may be helpful in the diagnosis of OSA.

Sestrin2 and Beclin1 levels in Polycystic Ovary Syndrome

“…Additionally, it has recently been proven that high plasma concentrations of sestrin2 in patients with chronic heart failure significantly increase the occurrence of major adverse cardiac events and predict poor outcome 47 . Levels of plasma sestrin2 have also been reported to be considerably high in patients with obstructive sleep apnea, 48 as well as those with asthma, 49 which again may be a compensatory mechanism to combat chronic hypoxia 48,49 . Elevated plasma levels of sestrin2 in different malignancies such as lung and colorectal cancers suggest a tumor‐suppressive role for this protein 50,51 .…”

“…47 Levels of plasma sestrin2 have also been reported to be considerably high in patients with obstructive sleep apnea, 48 as well as those with asthma, 49 which again may be a compensatory mechanism to combat chronic hypoxia. 48,49 Elevated plasma levels of sestrin2 in different malignancies such as lung and colorectal cancers suggest a tumor-suppressive role for this protein. 50,51 Moreover, significantly increased serum levels of sestrin2 have been demonstrated in Parkinson's disease and Alzheimer's disease, with a significant negative correlation with the mental and cognitive state.…”

Target Sestrin2 to Rescue the Damaged Organ: Mechanistic Insight into Its Function

“…Chai et al proposed the Sestrin2 plasma level of 1.86 ng/mL as a diagnostic cut-off value for OSA with a sensitivity of 81.58% and a specificity of 61.54%. In addition, 5.21 ng/mL plasma Sestrin2 has been proposed as a cut-off value for severe OSA with a sensitivity of 61.90% and a specificity of 90.70% [187]. OSA is also complicated with several metabolic complications such as cardiovascular diseases in which Sestrin2 plays an ameliorative role [188].…”

Sestrin2 in hypoxia and hypoxia-related diseases

“…It has been widely reported that hypoxia-related diseases are related to Sestrin2 [12,26]. In hypoxia-related diseases, hypoxia leads to imbalance of redox homeostasis because of excessive accumulation of reactive oxygen species (ROS) [27], which causes dysfunction of cells [14]. In addition, hypoxia activates HIF-1α, resulting in the activation of Sestrin2 [28][29][30].…”

“…In addition, the level of Sestrin2 is significantly higher in plasma and urine of OSA patients, and is positively correlated with AHI, even is helpful to the diagnosis of OSA [ 27 , 65 , 66 ]. Moreover, the level of Sestrin2 is lower after treatment of CPAP which can effectively alleviate intermittent hypoxia and oxidative stress in OSA patients [ 66 ].…”