Diagnostic value of subependymal pseudocysts and choroid plexus cysts on neonatal cerebral ultrasound: a meta-analysis

Álvarez, Jesús Cuéllar; Amess, P; Gandhi, Rashmi; Rabe, Heike

doi:10.1136/adc.2008.155028

Cited by 33 publications

(29 citation statements)

References 38 publications

(37 reference statements)

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“…In the present study, 3.7% (119/ 3186) of all examined neonates were found to have cystic lesions, which is similar to other reports (Table 1). 27 Of those cystic lesions found, we found that 31.1% (37/119) presented as bilateral intracranial cysts (Table 2). However, we did not find any abnormal neurodevelopmental record in the following 18e24 months after discharge.…”

Section: Discussionmentioning

confidence: 94%

“…27 The presence of an isolated subependymal cyst or a choroid plexus cyst usually resolves after a variable period of time, 29 and no serious neurodevelopmental complications occur in most cases. 29 However, in the meta-analysis of Alvarez and colleagues, 27 they found that one in four to five infants with bilateral multiple subependymal cysts or choroid plexus cysts may have a congenital infection or genetic anomaly.…”

Section: Discussionmentioning

confidence: 99%

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Cranial ultrasonographic findings in healthy full-term neonates: A retrospective review

Hsu¹,

Lee²,

Jeng³

et al. 2012

Journal of the Chinese Medical Association

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The incidence of minor and major anomalies detected by cranial ultrasonographic screening examinations in healthy full-term neonates is 6.3% and 0.06%, respectively. Thus, cranial ultrasonographic screening testing may play a role in the early diagnosis of intracranial anomalies of otherwise healthy neonates. However, this examination cannot exclude or detect all cranial abnormalities, including many potential neurologic diseases of neonates, so continuing clinical diligence is still important for all infants.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Cranial ultrasonographic findings in healthy full-term neonates: A retrospective review

Hsu¹,

Lee²,

Jeng³

et al. 2012

Journal of the Chinese Medical Association

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“…The detection of SEPCs has increased with the use of routine cerebral ultrasound (CUS); however, to our knowledge, there is no algorithm in the literature guiding clinicians, who face this pathology. As suggested in a recent meta-analysis,16 we prospectively enrolled newborns with SEPCs for follow-up, described the population characteristics and assessed the neurodevelopment at 6, 18 and 46 months.…”

Section: Introductionmentioning

confidence: 99%

Neurodevelopment outcome of newborns with cerebral subependymal pseudocysts at 18 and 46 months: a prospective study

Guex

Graz

Truttmann

2013

Archives of Disease in Childhood

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“…13–15 Unilateral subependymal, pseudo-, and choroid plexus cysts were not included in “any lesions” and excluded from the analysis as incidental findings. 16 …”

Section: Methodsmentioning

confidence: 99%

Prevalence and risk factors of cerebral lesions in neonates after laser surgery for twin-twin transfusion syndrome

Vanderbilt

Schrager

Llanes

et al. 2012

American Journal of Obstetrics and Gynecology

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Objective To identify risk factors for cerebral lesions among survivors of TTTS treated with laser surgery. Study Design A multilevel regression analysis examined risk factors for neonatal cerebral lesions identified by imaging. Imaging was routine in “high-risk survivors”, defined as those delivered at <32 weeks' gestation, and by clinical indications if born later. Severe lesions were defined as: intraventricular hemorrhage grade III–IV, cystic periventricular leukomalacia, ventriculomegaly and/or hydrocephalus, microcephaly, infarctions, porencephalic/Dandy-Walker cysts, or bilateral other cysts. Results For 262 consecutive laser-treated TTTS patients, 18 neonates had severe lesions identified among 427 individual survivors (4.2%) and 242 “high-risk survivors” (7.4%). Forty-six newborns had any cerebral lesion, resulting in lesion rates of 10.8%–19.0%. Delivery <32 weeks' (OR=4.95, p<0.001) and <28 weeks' (OR=6.25, p<0.001) gestation were associated with increased likelihood of any cerebral lesion. Conclusions This cohort showed low rates (4–7%) of severe neonatal cerebral lesions, with prematurity being the primary risk factor.

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Diagnostic value of subependymal pseudocysts and choroid plexus cysts on neonatal cerebral ultrasound: a meta-analysis

Abstract: Bilateral multiple subependymal pseudocysts or choroid plexus cysts suggest an underlying disease. Further investigations should be undertaken even if the patient is otherwise normal. Parents of well newborns with a single cyst should be reassured.

Cited by 33 publications

References 38 publications

Cranial ultrasonographic findings in healthy full-term neonates: A retrospective review

Cranial ultrasonographic findings in healthy full-term neonates: A retrospective review

Neurodevelopment outcome of newborns with cerebral subependymal pseudocysts at 18 and 46 months: a prospective study

Prevalence and risk factors of cerebral lesions in neonates after laser surgery for twin-twin transfusion syndrome

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