Diagnostic Value of¹⁸F-FDG PET/CT in Comparison to Bone Scintigraphy, CT and¹⁸F-FDG PET for the Detection of Bone Metastasis

A comparative study of 18F-fluorodeoxyglucose positron emission tomography/computed tomography and 99mTc-MDP whole-body bone scanning for imaging osteolytic bone metastases

“…The early detection of bone metastases has significance in clinical staging, treatment, and prognosis [1,2]; imaging modalities that reveal these metastases, therefore, play an important clinical role. A number of different modalities have proven valuable in the detection of bone metastases; however, all non-invasive techniques currently in use have certain weaknesses [3]. 99m Tc- methylenediphosphonate (MDP) whole-body bone scanning (BS) is a conventional method used for the detection of bone metastases with a high sensitivity and at a low price.…”

“…Early metastatic lesions may be missed; however, BS imaging relies on identifying an osteoblastic reaction rather than on the direct detection of tumor cells. Furthermore, low spatial resolution and low sensitivity to the treatment response restrict the use of BS [3]. When evaluating large numbers of suspected bone metastasis cases, bone scintigraphy is the most commonly used modality owing to its high sensitivity and availability, low cost, and the ease with which the entire skeleton can be surveyed.…”

Retrograde Analysis of Clinical Characteristics of Bone Metastasis in 1,031 Cases of Preliminarily Diagnosed Nasopharyngeal Carcinoma

“…Part of patients having BM before treatment or after routine radiotherapy was ignored, which could significantly affected patients' prognosis. Recent studies have shown that 18F-FDG PET/CT may enhance our diagnosis of tumor bone metastasis and provide more information for cancer treatment (Liu, 2013).…”

Standardized Uptake Values Highly Correlate with Tumor Size and Fuhrman Grade in Patients with Clear Cell Renal Cell Carcinoma

“…Fluorine-18 fluoro-2 deoxyglucose (FDG) positron emission tomography (PET) has been recognised as an efficient imaging modality for the management of oncology patients and has been used increasingly for primary staging, detection of recurrence, assessment of residual masses and monitoring therapeutic response in various types of cancers (Bomanji et al, 2001). Also it has become an important tool for the detection of bone metastasis (Liu et al, 2013 18-F-FDG accumulation rate evaluated by PET and patient prognosis. The standardized uptake value (SUV) is a semiquantitative simplified measurement of the tissue FDG accumulation rate, and the recent studies of the head-and-neck, esophagus, lung, and cervical cancer have explored the prognostic significance of the maximum standardized uptake value (SUVmax) (Sasaki et al, 2005;Lee et al, 2009;Ma et al, 2013;Uzel et al, 2013;Zhu et al, 2013).…”