Diagnostic values of 68Ga-labelled DOTANOC PET/CT imaging in pediatric patients presenting with paraneoplastic opsoclonus myoclonus ataxia syndrome

Kumar, Rajender; Kousik, Vankadari; Mittal, Bhagwant Rai; Bansal, Deepak; Trehan, Amita; Sahu, Jitendra Kumar; Sankhyan, Naveen

doi:10.1007/s00330-020-07587-x

Cited by 10 publications

(12 citation statements)

References 19 publications

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“…NETs are rare tumors arising from the neural crest cells dispersed throughout the body and belong to the amine precursor and decarboxylation group. [1][2][3][4] NETs can be classified into functional or nonfunctional subgroups based on the production of amine/hormone, with most of them showing the expression of several receptors in high quantities. 5 The NETs are associated with overexpression of somatostatin receptor (SSTR) receptors, mainly SSTR 2, 3, and 5.…”

Section: Figurementioning

confidence: 99%

“…In addition, increased tracer uptake is also localized to the gall bladder and bile ducts on axial PET ( H ), CT ( I ), and fused PET/CT ( J ). NETs are rare tumors arising from the neural crest cells dispersed throughout the body and belong to the amine precursor and decarboxylation group 1–4 . NETs can be classified into functional or nonfunctional subgroups based on the production of amine/hormone, with most of them showing the expression of several receptors in high quantities 5 .…”

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confidence: 99%

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Exceptional Visualization of the Gallbladder on 68Ga-DOTANOC PET/CT Imaging

2022

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Neuroendocrine tumors (NETs) are rare tumors associated with the overexpression of somatostatin receptors owing to their origin from neural crest cells. The somatostatin receptor-based molecular imaging of NETs with 68 Ga-DOTANOC is extensively used to diagnose primary and metastatic disease with high diagnostic accuracy. Unlike conventional octreotide imaging, physiological gallbladder uptake is not seen on 68 Ga-DOTANOC PET/CT imaging. The present case report exhibits the rare physiological 68 Ga-DOTANOC uptake in the gall bladder and bile duct.

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Section: Figurementioning

confidence: 99%

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Exceptional Visualization of the Gallbladder on 68Ga-DOTANOC PET/CT Imaging

2022

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“…In a large series of 73 patients with NT, only 5 (6.8%) had OMAS; neuroblastoma was diagnosed in 2 and GN in 1 8. In another series of 17 patients with NT and OMAS, neuroblastoma was diagnosed in 14, and GN in 1 9. In a meta-analysis of 364 patients with GN, OMAS was not listed as a common associated feature 7…”

Section: Introductionmentioning

confidence: 99%

Benign paraspinal ganglioneuroma with paraneoplastic opsoclonus myoclonus syndrome

Prabaharan,

Chandrasekaran,

Shetty

et al. 2024

BMJ Case Rep

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Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare immune-mediated movement disorder occurring as a paraneoplastic manifestation of neuroblastic tumours (NTs), especially neuroblastoma in infancy. Ganglioneuroma (GN), the benign tumour in the spectrum, is rarely associated with OMAS. We report the case of a child in her second year of life presenting with acute onset of progressive paraplegia and OMAS. MRI showed diffuse and infiltrating left paraspinal mass from T3–T9 levels with differentials of neuroblastoma or ganglioneuroblastoma. Histopathological and immunohistochemistry examination of the excised tumour showed maturing GN. The OMAS was managed with intravenous immunoglobulin and steroids. In the 6-month follow-up, the child has a residual motor weakness with myelomalacia in neuroimaging. The case report substantiates the occurrence of OMAS as paraneoplastic manifestation in NTs, including benign, in children younger than 2 years with a female predilection.

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“…1 Owing to increased SSTR expression in neuroendocrine tumors and hemangioblastoma, 68 Ga-SSTR imaging plays a vital role in the VHL syndrome evaluation. [2][3][4] Apart from the oncological indications, the use of 68 Ga-SSTR imaging is not much explored. However, only a few active inflammatory conditions have been reported with 68 Ga-SSTR avidity.…”

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confidence: 99%

“…68 Ga-DOTANOC shows a high affinity to SSTR types 2, 3, and 5 1 . Owing to increased SSTR expression in neuroendocrine tumors and hemangioblastoma, 68 Ga-SSTR imaging plays a vital role in the VHL syndrome evaluation 2–4 . Apart from the oncological indications, the use of 68 Ga-SSTR imaging is not much explored.…”

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confidence: 99%

Incidental Detection of Viral Conjunctivitis on 68Ga-DOTANOC PET/CT in a Patient Suspected With Von Hippel–Lindau Syndrome

et al. 2022

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Von Hippel-Lindau syndrome is an autosomal dominant disorder. It is associated with a spectrum of benign and malignant tumors, including pancreatic and adrenal neuroendocrine tumors, renal cell carcinoma, and hemangioblastomas of the central nervous system and retina. 68 Ga-DOTANOC PET/CT has shown somatostatin receptor expression in inflammatory conditions. In the present case, we report that 68 Ga-DOTANOC PET/CT demonstrates the tracer avidity in the bilateral swollen eyelids in a patient with clinical suspicion of Von Hippel-Lindau syndrome, which was confirmed as viral conjunctivitis on clinical examination.

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Diagnostic values of 68Ga-labelled DOTANOC PET/CT imaging in pediatric patients presenting with paraneoplastic opsoclonus myoclonus ataxia syndrome

Cited by 10 publications

References 19 publications

Exceptional Visualization of the Gallbladder on 68Ga-DOTANOC PET/CT Imaging

Exceptional Visualization of the Gallbladder on 68Ga-DOTANOC PET/CT Imaging

Benign paraspinal ganglioneuroma with paraneoplastic opsoclonus myoclonus syndrome

Incidental Detection of Viral Conjunctivitis on 68Ga-DOTANOC PET/CT in a Patient Suspected With Von Hippel–Lindau Syndrome

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