Diagnostic yield of post-bronchoscopy sputum smear in pulmonary tuberculosis

Malekmohammad, Majid; Marjani, Majid; Tabarsi, Payam; Baghaei, Parvaneh; Sadr, Zahra; Naghan, Parisa Adimi; Mansouri, Davood; Masjedi, Mohammad Reza; Velayati, Ali Akbar

doi:10.3109/00365548.2011.643820

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…Davon sollen mindestens drei an unterschiedlichen Tagen gewonnene Proben untersucht werden. Falls ohnehin eine bronchoskopische Untersuchung durchgeführt wird, stellt die Entnahme von Sputum nach der Untersuchung eine wertvolle ergänzende diagnostische Möglichkeit dar [84,85].…”

Section: Präanalytikunclassified

S2k-Leitlinie: Tuberkulose im Erwachsenenalter

et al. 2017

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Since 2015 a significant increase in tuberculosis cases is notified in Germany, mostly due to rising numbers of migrants connected to the recent refugee crisis. Because of the low incidence in previous years, knowledge on tuberculosis is more and more limited to specialized centers. However, lung specialist and healthcare workers of other fields have contact to an increasing number of tuberculosis patients. In this situation, guidance for the management of standard therapy and especially for uncommon situations will be essential. This new guideline on tuberculosis in adults gives recommendations on diagnosis, treatment, prevention and prophylaxis. It provides a comprehensive overview over the current knowledge, adapted to the specific situation in Germany. The German Central Committee against Tuberculosis (DZK e. V.) realized this guideline on behalf of the German Respiratory Society (DGP). A specific guideline for tuberculosis in the pediatrics field will be published separately. Compared to the former recommendations of the year 2012, microbiological diagnostics and therapeutic drug management were given own sections. Chapters about the treatment of drug-resistant tuberculosis, tuberculosis in people living with HIV and pharmacological management were extended. This revised guideline aims to be a useful tool for practitioners and other health care providers to deal with the recent challenges of tuberculosis treatment in Germany.

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Section: Präanalytikunclassified

S2k-Leitlinie: Tuberkulose im Erwachsenenalter

et al. 2017

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“…PBS could be collected after bronchoscopy examinations easily. It has been reported that a no negligible portion of patients (about 9%–25%) were diagnosed with pulmonary TB based on AFB smear microscopy and mycobacterial culture of PBS exclusively in previous studies [ 3 , 4 , 16 ]. It is meaningful to diagnose additional patients with pulmonary TB rapidly based on AFB smear microscopy of PBS for public health and infection control.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic yield of post-bronchoscopy sputum for diagnosing pauci-bacillary pulmonary tuberculosis

Park

Shim

et al. 2021

Annals of Medicine

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Background A few studies have mentioned that post-bronchoscopy sputum (PBS) could improve the diagnostic yield in pauci-bacillary pulmonary tuberculosis (PTB). Therefore, we evaluated the diagnostic yield of PBS for diagnosing pauci-bacillaryPTB. Methods Clinical data of immunocompromised adult patients with pauci-bacillary PTB were retrospectively retrieved at a tertiary hospital in Seoul, South Korea over a 5-year period. We analyzed patients who underwent bronchoscopy examinations for diagnosing pauci-bacillary PTB. Results Ninety patients were finally analyzed. Of these patients, 76 patients were tested with PBS. Six (8%) of these patients had positive results on AFB smear of PBS alone. Additionally, 52 patients (68%) had positive results on mycobacterial culture and 12 (16%) had positive results on mycobacterial culture of PBS exclusively. Therefore, in this study population, a total of 18 patients (20%) were finally diagnosed as having PTB with PBS results only, even though AFB smear microscopy and culture of other specimens had negative results. Conclusions PBS could improve the diagnostic yield by 20% when diagnosing pauci-bacillary PTB. In addition, about 8% of the patients could be diagnosed rapidly because of AFB smear microscopy positivity for PBS. Therefore, PBS use should be considered as a complementary diagnostic approach in patients with suspected pauci-bacillary PTB.

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“…This often leads to the next step being BAL and bronchoscopy [ 12 ]. One study elicited a sensitivity of 57.1% for BAL smear, and a sensitivity of 76.7% for post-bronchoscopy smear [ 13 ]. These findings have shown that bronchoscopy and BAL are both viable and available avenues of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Pleural Tuberculosis: A Febrile Presentation Without Respiratory Symptoms

Ghumman¹,

Ghumman²,

Nawab³

et al. 2020

Cureus

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Tuberculosis (TB) is one of the largest public health crises globally, with pleural TB comprising a large portion of cases. It has a significantly minimal presence within the United States in comparison to the rest of the world. Awareness of its presence and acumen on diagnostics and treatment are essential. Conventional tests are often time consuming, and do not always yield accurate results. We present the case of a patient presenting with fevers but no cough, who eventually found to have large pleural effusion and concluded to have pleural TB without pulmonary parenchymal involvement. He then showed measurable improvement with empiric treatment.

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Diagnostic yield of post-bronchoscopy sputum smear in pulmonary tuberculosis

Abstract: Evaluation of post-bronchoscopy sputum smears is helpful for earlier diagnosis of pulmonary TB and is an inexpensive and accessible assay.

Cited by 17 publications

References 18 publications

S2k-Leitlinie: Tuberkulose im Erwachsenenalter

S2k-Leitlinie: Tuberkulose im Erwachsenenalter

Diagnostic yield of post-bronchoscopy sputum for diagnosing pauci-bacillary pulmonary tuberculosis

Pleural Tuberculosis: A Febrile Presentation Without Respiratory Symptoms

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