Diagnostics and treatment of Helicobacter pylori infection in children

Belmer, S.V.; Корниенко, Е. А.; Волынец, Г. В.; Гурова, М. М.; Zvyagin, A.A.; Камалова, А. А.; Луппова, Н. Е.; Нижевич, А. А.; Новикова, В. П.; Pechkurov, D.V.; Privorotsky, V.F.; Сатаев, В. У.; Tyazheva, A.A.; Файзуллина, Р. А.; Хавкин, А.И.

doi:10.31146/1682-8658-ecg-193-9-119-127

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…В периоде обострения дети с хеликобактерассоциированным ХГД получали в качестве базисной терапии антисекреторные (омепразол) и антибактериальные препараты (амоксициллин, кларитромицин) в возрастных дозировках в течение 14 дней согласно рекомендациям Общества детских гастроэнтерологов, гепатологов, нутрициологов [8]. Кроме того, учитывались рекомендации Российской гастроэнтерологической ассоциации (РГА), подчеркивающие необходимость канцеропревенции в России, стране с высокой частотой встречаемости рака желудка [9].…”

Section: материалы и методыunclassified

The state of psycho-emotional status in adolescent children with chronic gastroduodenitis, associated with Helicobacter pylori infection in the period of exacerbation and remission

Gurova

2023

APPS

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Relevance. In the pathogenesis of chronic gastroduodenitis, along with an infectious factor (Helicobacter Pylori infection), an important role is played by the state of the patient’s psycho-emotional status, which is characterized by a high incidence of anxiety and subdepressive states in adolescence. Goals: to assess the state of the psycho-emotional status and quality of life in adolescent children with chronic gastroduodenitis associated with Helicobacter pylori infection in the period of exacerbation, after 1 month and 6 months after successful eradication therapy. Materials and methods. The prospective case-control study included 60 adolescent children with morphologically proven chronic gastroduodenitis associated with Helicobacter pylori infection (main group) in the period of exacerbation, in 1 month. and 6 months. after successful eradication therapy. As a comparison group, 22 schoolchildren with the first health group were taken, comparable in age and gender with the children of the main group. All children underwent psychological testing (Spielberger test to assess the levels of reactive and personal anxiety, Zung test to determine the level of depression) and assessed the quality of life. Results. During the period of remission, more than half of the children with chronic gastroduodenitis had complaints common for asthenic syndrome: weakness, mental exhaustion, and headaches. In the period of exacerbation, the highest rates were noted on the scales of personal and reactive anxiety, depression, followed by improvement during treatment and worsening of indicators after 6 months after eradication therapy. Quality of life indicators, characterized by improvement after eradication therapy, after 6 months. showed a statistically significant decrease on the scales of physical functioning (RP), general health (GH), vitality (VT) and mental health (MH). Conclusion: Adolescent children with chronic gastroduodenitis characterized by changes in the psycho-emotional status in the form of subdepression and increased anxiety, both reactive and personal. These changes are not completely stopped after the use of traditional therapy for chronic gastroduodenitis and persist in the period of remission, worsening the quality of life, increasing the negative perception of the disease and treatment prospects.

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The state of psycho-emotional status in adolescent children with chronic gastroduodenitis, associated with Helicobacter pylori infection in the period of exacerbation and remission

Gurova

2023

APPS

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“…Россия относится к странам с высокой распространённостью Hp-инфекции. Её обнаруживают у 65-92% взрослого населения, у 29% детей в возрасте 5-10 лет и у 56% подростков в возрасте 11-14 лет [10]. Распространённость Hp среди медицинских работников составляет 55-71%.…”

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“…Одновременно Нp-инфекцию у детей изучали Европейское и Североамериканское общества детской гастроэнтерологии, гепатологии и нутрициологии, которые и ныне выпускают рекомендации по диагностике и лечению этой инфекции у детей [27]. Работу над созданием рекомендаций по диагностике и лечению Нp-инфекции для педиатров ведёт Российское общество детских гастроэнтерологов, гепатологов и нутрициологов [10].…”

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Modern aspects of Helicobacter pylori infection

Yakovleva

Смирнова

Korsunskiy

2023

RPJ

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A systematic review of current data on the structure and functions of Helicobacter pylori (Hp), pathogenesis, diagnosis and treatment of Hp-infection is presented. The relevance of the topic of helicobacteriosis is due to the proven connection of this infection with chronic, widespread diseases of the digestive organs among the population. The review used materials from the databases including PubМed, Medline, EMBASE, Scopus, Google Scholar, RSCI. A systematic review based on studies with a high degree of evidence has shown significant progress in the diagnosis and treatment of Hp-infection in recent years in adults and children. Coordination of the scientific search for the regularities of the formation of Hp-associated forms of pathology, continuous improvement of diagnostic technologies and the search for new therapies, periodic well-organized international revisions of standard methods of Hp diagnosis and treatment contribute to the creation of effective methods of Hp eradication, preservation of the optimal composition of the microbiota of the gastrointestinal tract and prevention of antibiotic resistance. Of particular importance for the prevention of complications of Hp-infection are original diagnostic algorithms using specialized endoscopic and molecular technologies before and after Hp eradication with long-term follow-up and the determination of the leading factors correlating with a high risk of stomach cancer. The review indicates the emergence of potentially effective and promising areas for the diagnosis and treatment of Hp-infection, including genetic modification of the Hp genome to ensure its existence as a human symbiont and a significant reduction in its pathogenic properties. At the same time, sequencing of a new generation reveals mutations in Hp genes associated with its pathogenicity and antibiotic resistance, which contributes to the creation of new classes of drugs to increase the effectiveness of Hp eradication with a decrease in the proportion of antibiotics and an increase in pathogenetically significant inhibitors of its pathogenic factors for the prevention of side effects, a significant reduction in the empirical use of several antibiotics and increased compliance to treatment.

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Proton pump inhibitors in pediatric practice

Shilova,

Alieva,

Bashkina

et al. 2023

Pediatr. farmakol.

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The scientific review of the literature provides information on current clinical observations of the use of proton pump inhibitors in large randomized trials of Russian and foreign scientists, issues of their classification, pharmacokinetics, pharmacodynamics, pharmacogenetics, efficacy and safety of prescribing in pediatric practice, due to the growth of acid-dependent conditions in children and the need for further systematic research with the development of approaches to personalization of prescribing drugs for each age group.

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Diagnostics and treatment of Helicobacter pylori infection in children

Abstract: .

Cited by 4 publications

References 24 publications

The state of psycho-emotional status in adolescent children with chronic gastroduodenitis, associated with Helicobacter pylori infection in the period of exacerbation and remission

The state of psycho-emotional status in adolescent children with chronic gastroduodenitis, associated with Helicobacter pylori infection in the period of exacerbation and remission

Modern aspects of Helicobacter pylori infection

Proton pump inhibitors in pediatric practice

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