Diagnostics of Early Changes in the Immune System Due to Low Concentration of N-Nitrosamines in the Blood

Zaitseva, Nina V.; Ulanova, T.S.; Dolgikh, O.V.; Nurislamova, Tatyana V.; Mal'Tseva, O. A.

doi:10.1007/s10517-018-3984-2

Cited by 10 publications

(3 citation statements)

References 4 publications

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“…ID: “The concentration of N-nitrosamines (N-nitrosodimethylamine and N-nitrosodiethylamine) was measured in blood samples from children after consumption of drinking water with high content of nitrates … The specific immune response to N-nitrosodimethylamine exposure was manifested in an increase in the level of specific serum IgG (2 times higher than that in the reference group). An increase in the specific sensitivity to N-nitrosodimethylamine (by the criterion of IgG) was observed in 60.7% subjects.” [ 100 ]…”

Section: Commonality Of Contributing Factors Between Ibd and Id - Detailsmentioning

confidence: 99%

Common contributing factors to COVID-19 and inflammatory bowel disease

Kostoff

Briggs²,

Kanduc

et al. 2021

Toxicology Reports

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Section: Commonality Of Contributing Factors Between Ibd and Id - Detailsmentioning

confidence: 99%

Common contributing factors to COVID-19 and inflammatory bowel disease

Kostoff

Briggs²,

Kanduc

et al. 2021

Toxicology Reports

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“…They are toxic for the kidneys, urinary bladder, liver, intestine, esophagus, and stomach. High and low doses of N‐nitrosodimethylamine (DMN) lead to the development of tumors in the liver and kidneys (Zaitseva, Ulanova, Dolgikh, Nurislamova, & Mal’tseva, ). DMN is an effective carcinogen found in drinking water, foods, and groundwater.…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective effect ofFerulago angulataflowers on N‐nitrosodimethylamine‐induced nephrotoxicity in rats and its phytochemical profile

et al. 2019

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The present study was designed to assess the phytochemical content of Ferulago angulata (FA) and possible in vivo nephroprotective effect of FA administration on trace elements, minerals, MDA and GSH in kidney and liver tissue samples, serum vitamin (α‐tocopherol, retinol, cholecalciferol, phylloquinone), TSA, and LSA in a rat model of DMN‐induced nephrotoxicity. In the study, Wistar albino rats were assigned to six groups: Control (0.9% NaCl), (DMN 10 mg/kg), (FA 150 mg/kg), (DMN + FA 150 mg/kg), (FA 300 mg/kg), and (DMN + FA 300 mg/kg). Rats were intraperitoneally given DMN for the first 7 days. Renal injury caused by DMN was proved by the histopathological alterations. The FA (300 mg/kg) treatment significantly normalized Se, Cr, Ca levels in liver and Co level in kidney tissue samples. These observed positive effects are due to the phytochemical content of the plant. The flower extract of FA (300 mg/kg) can be used for the prevention of kidney damage. Practical applications Ferulago angulata flowers are used in traditional medicine for treat kidney and liver digestive system diseases. This species is endemic taxa of the family Apiaceae, which has been used both as food and therapeutics because of their phytochemical composition. In this study, the phenolic characterization of FA flower was used to a new RP‐HPLC method, as well as the biological activity of FA flower and possible in vivo nephroprotective effect of FA flowers on trace elements, minerals, MDA and GSH in kidney and liver tissue samples and vitamins, TSA, and LSA in serum samples a rat model of DMN‐induced nephrotoxicity. It was found that high level of phenolic compounds (chlorogenic acid, vanillic acid, 2‐hydroxycinnamic acid) present in the flower extract of F. angulata has positive effects and antioxidant properties. Due to its phenolic content, FA flower extract could protect for kidney damage and can be used as antioxidants in the food additive and pharmaceutical industry.

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“…To develop an optimal diagnostic combination of genetic markers (test-systems) for each food product is a most significant task that needs to be solved for providing food products quality and safety. Real-time polymerase chain reaction is an efficient technique for nucleic acids analysis [8][9][10][11][12].…”

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confidence: 99%

Genetically modified food products: peculiarities of genetic identification

Mukhammadiyeva¹,

Каримов²,

Dolgikh³

et al. 2018

Health Risk Analysis

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Our research goal was to perform a genetic analysis of food stuffs produced in Russia in order to determine whether genetically modified components, predominantly soya, occurred in them. We also set a task to draw up an optimal list of genetic modifiers for sausages and soya products; this list was to be applied as a tool for monitoring of undeclared GMO and for providing biological safety of food stuffs. We applied polymerase chain reaction in real-time mode to analyze certain food products (sausages and soya products); the analysis was to reveal genetically modified organisms. The task was to identify the following GMO genes: promoters (p35SCaMV, P-SSuAra, Ubi1, ract1, hsp70, TA29 tobacco promoter), terminators (nos3, T-E9, T-g7, T-OCS), reporter genes (nptll, qHptFP308, bar, pat_10-P), bio-pesticides Bacillus Thuringensis (Bt) or Cry-toxins (Cry1Ab/Ac), reporter gene of β-glucuronidase (GUS-gene). Analysis of some sausage samples allowed us to identify the following GMO

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Diagnostics of Early Changes in the Immune System Due to Low Concentration of N-Nitrosamines in the Blood

Cited by 10 publications

References 4 publications

Common contributing factors to COVID-19 and inflammatory bowel disease

Common contributing factors to COVID-19 and inflammatory bowel disease

Nephroprotective effect ofFerulago angulataflowers on N‐nitrosodimethylamine‐induced nephrotoxicity in rats and its phytochemical profile

Genetically modified food products: peculiarities of genetic identification

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