Diallyl disulfide causes caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway

Nagaraj, Nagathihalli S.; Anilakumar, K.R.; Singh, Om V.

doi:10.1016/j.jnutbio.2009.01.015

Cited by 49 publications

(32 citation statements)

References 43 publications

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“…Recently, significant attention has been focused on natural radio protective agent in vegetables and fruits. 25 13,14,[27][28][29][30] Therapeutic approaches based on the combination of high-LET carbon beams and DADS aim at increasing clinical responses while lowering the radiation dosages and cancer cell resistance. The advantage of combination stems from the fact that each one can have a single target or mechanism of action or this combination may share the same target or mechanism of action against cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Diallyl disulfide enhances carbon ion beams–induced apoptotic cell death in cervical cancer cells through regulating Tap73 /ΔNp73

Chen

Sun

et al. 2015

Cell Cycle

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Diallyl disulfide (DADS), extracted from crushed garlic by steam-distillation, has been reported to provide the anticancer activity in several cancer types. However, the effect of DADS on high-LET carbon beams -induced cell death remains unknown. Therefore, we used human cervical cancer cells to elucidate the molecular effects of this dallyl sulfide. Radiotherapy remains the mainstay of treatment, especially in advanced cervical cancer and there is still space to improve the radiosensitivity to reduce radiation dosage. In this study, we found that radiation effects evoked by high-LET carbon beam was marked by inhibition of cell viability, cell cycle arrest, significant rise of apoptotic cells, regulation of transcription factor, such as p73, as well as alterations of crucial mediator of the apoptosis pathway. We further demonstrated that pretreatment of 10 mM DADS in HeLa cells exposed to radiation resulted in decrease in cell viability and increased radiosensitivity. Additionally, cells pretreated with DADS obviously inhibited the radiationinduced G2/M phase arrest, but promoted radiation-induced apoptosis. Moreover, combination DADS and the radiation exacerbated the activation of apoptosis pathways through up-regulated ration of pro-apoptotic Tap73 to antiapoptotic DNp73, and its downstream proteins, such as FASLG, and APAF1. Taken together, these results suggest that DADS is a potential candidate as radio sensitive agent for cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Diallyl disulfide enhances carbon ion beams–induced apoptotic cell death in cervical cancer cells through regulating Tap73 /ΔNp73

Chen

Sun

et al. 2015

Cell Cycle

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“…Caspase is an inactive enzyme zymogen under normal circumstances, but once activated it will trigger the caspase cascade, eventually leading to apoptosis. In the central control and effective stage of apoptosis, activated caspase-8 can lead directly to the appearance of apoptotic structural characteristics in cells, and play a key role in the process of apoptosis (6,7).…”

Section: Introductionmentioning

confidence: 99%

Caspase-8 and p38MAPK in DATS-induced apoptosis of human CNE2 cells

Feng-lian

2010

Braz J Med Biol Res

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“…Caspases, a family of cysteine proteases, are the central regulators of apoptosis. Caspase-3 is the main downstream effector caspase that performs essential roles in degrading the majority of key cellular components in apoptotic cells (26,27). In the present study, western blot analysis was performed to determine whether Bax/Bcl-2 and caspase-3 were involved in the process of apoptosis induced by 1a in the three human cancer cell lines.…”

Section: Discussionmentioning

confidence: 94%

Design and synthesis of novel N(4)-substituted thiosemicarbazones bearing a pyrrole unit as potential anticancer agents

et al. 2017

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Abstract.A series of N(4)-substituted thiosemicarbazones (TSCs) bearing pyrrole unit (1a-1e) were synthesized and fully characterized by elemental analyses, infrared spectra, 1 H nuclear magnetic resonance and single crystal X-ray diffraction. The compounds were assessed as potential chemotherapeutic agents. All newly synthesized compounds were screened for their anticancer activity against lung cancer PC-9, esophageal cancer Eca-109 and gastric cancer SGC-7901 cell lines. The results of MTT, Terminal deoxynucleotidyl transferase dUTP nick end labeling and fluorescence-activated cell sorting assays indicated that all the prepared compounds exhibited cytotoxicity against PC-9, Eca-109 and SGC-7901 cells in vitro. All the compounds significantly induced cancer cell apoptosis accompanied by increasing the Bax/Bcl-2 ratio and activation of caspase-3. The structure-activity association was discussed and the potential pre-clinical trials may be conducted. The present findings have a great potential in biomedical applications of novel N(4)-substituted TSCs.

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Diallyl disulfide causes caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway

Cited by 49 publications

References 43 publications

Diallyl disulfide enhances carbon ion beams–induced apoptotic cell death in cervical cancer cells through regulating Tap73 /ΔNp73

Diallyl disulfide enhances carbon ion beams–induced apoptotic cell death in cervical cancer cells through regulating Tap73 /ΔNp73

Caspase-8 and p38MAPK in DATS-induced apoptosis of human CNE2 cells

Design and synthesis of novel N(4)-substituted thiosemicarbazones bearing a pyrrole unit as potential anticancer agents

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