Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells

Kiesel, Violet A.; Stan, Silvia D.

doi:10.1016/j.bbrc.2017.01.184

Cited by 44 publications

(29 citation statements)

References 31 publications

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“…Organosulfur compounds not only modulate glutathione and phase II enzymes and inhibit inflammatory mediators, they also inhibit several cancers. Previous findings suggest that a diet supplemented with diallyl trisulfide, diallyl disulfide, and diallyl sulfide suppressed cancers induced by chemical carcinogens (Huang J. et al, 2015 ; Su et al, 2016 ; Kiesel and Stan, 2017 ). In support of this, an animal study has demonstrated that oral administration of diallyl trisulfide at a dosage of 1–2 mg per day for 13 weeks significantly suppressed the progression of invasive carcinoma and multiplicity of pulmonary metastasis (Singh et al, 2008 ).…”

Section: Role Of Antioxidants In the Prevention Of Age-related Diseasmentioning

confidence: 98%

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

et al. 2018

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Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline. Oxidative stress is considered as an imbalance between pro- and antioxidant species, which results in molecular and cellular damage. Oxidative stress plays a crucial role in the development of age-related diseases. Emerging research evidence has suggested that antioxidant can control the autoxidation by interrupting the propagation of free radicals or by inhibiting the formation of free radicals and subsequently reduce oxidative stress, improve immune function, and increase healthy longevity. Indeed, oxidation damage is highly dependent on the inherited or acquired defects in enzymes involved in the redox-mediated signaling pathways. Therefore, the role of molecules with antioxidant activity that promote healthy aging and counteract oxidative stress is worth to discuss further. Of particular interest in this article, we highlighted the molecular mechanisms of antioxidants involved in the prevention of age-related diseases. Taken together, a better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.

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Section: Role Of Antioxidants In the Prevention Of Age-related Diseasmentioning

confidence: 98%

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

et al. 2018

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“…Furthermore, the studies revealed that the Notch-1 signaling pathway was disrupted by DATS. DATS inhibits the expression of proteases from the group of disintegrin and metalloproteases (ADAMs), especially ADAM-10 and ADAM-17, in estrogen-dependent and estrogen-independent breast cancer cells [ 131 ]. For another cancer where the Notch-signaling pathway is upregulated—osteosarcoma—DATS also proved to be efficient.…”

Section: Plant-derived Sulfur Compounds—gsls and Oscsmentioning

confidence: 99%

Health Benefits of Plant-Derived Sulfur Compounds, Glucosinolates, and Organosulfur Compounds

et al. 2020

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The broad spectrum of the mechanism of action of immune-boosting natural compounds as well as the complex nature of the food matrices make researching the health benefits of various food products a complicated task. Moreover, many routes are involved in the action of most natural compounds that lead to the inhibition of chronic inflammation, which results in a decrease in the ability to remove a pathogen asymptomatically and is connected to various pathological events, such as cancer. A number of cancers have been associated with inflammatory processes. The current review strives to answer the question of whether plant-derived sulfur compounds could be beneficial in cancer prevention and therapy. This review focuses on the two main sources of natural sulfur compounds: alliaceous and cruciferous vegetables. Through the presentation of scientific data which deal with the study of the chosen compounds in cancer (cell lines, animal models, and human studies), the discussion of food processing’s influence on immune-boosting food content is presented. Additionally, it is demonstrated that there is still a need to precisely demonstrate the bioavailability of sulfur-containing compounds from various types of functional food, since the inappropriate preparation of vegetables can significantly reduce the content of beneficial sulfur compounds. Additionally, there is an urgent need to carry out more epidemiological studies to reveal the benefits of several natural compounds in cancer prevention and therapy.

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“…In another cancer stem cell-related study, DATS reduced the CD44 high /CD24 low /ESA + population as well as aldehyde dehydrogenase (ALDH) activity in breast cancer cells [ 58 ]. More recently, DATS was shown to inhibit Notch ligands and alpha secretases in breast cancer cells [ 100 ].…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment

Puccinelli

Stan

2017

IJMS

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Bioactive dietary agents have been shown to regulate multiple cancer hallmark pathways. Epidemiologic studies have linked consumption of Allium vegetables, such as garlic and onions, to decreased incidence of cancer. Diallyl trisulfide (DATS), a bioactive compound derived from Allium vegetables, has been investigated as an anti-cancer and chemopreventive agent. Preclinical studies provide ample evidence that DATS regulates multiple cancer hallmark pathways including cell cycle, apoptosis, angiogenesis, invasion, and metastasis. DATS has been shown to arrest cancer cells at multiple stages of the cell cycle with the G2/M arrest being the most widely reported. Additionally, increased pro-apoptotic capacity as a result of regulating intrinsic and extrinsic apoptotic pathway components has been widely reported following DATS treatment. Invasion, migration, and angiogenesis represent emerging targets of DATS and support its anti-cancer properties. This review summarizes DATS mechanisms of action as an anti-cancer and chemopreventive agent. These studies provide rationale for future investigation into its use as a cancer chemopreventive agent.

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Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells

Cited by 44 publications

References 31 publications

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

Health Benefits of Plant-Derived Sulfur Compounds, Glucosinolates, and Organosulfur Compounds

Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment

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