Diallyl Trisulfide Augments Ischemia-Induced Angiogenesis via an Endothelial Nitric Oxide Synthase-Dependent Mechanism

Hayashida, Ryo; Kondo, Kazuhisa; Morita, Sumiharu; Unno, Kazumasa; Shintani, Satoshi; Shimizu, Yasuhiko; Calvert, John W.; Shibata, Rei; Murohara, Toyoaki

doi:10.1253/circj.cj-16-1097

Cited by 43 publications

(39 citation statements)

References 41 publications

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Section: Mechanismsmentioning

confidence: 99%

“…Addition of DATS to cultured human umbilical vein endothelium cells also decreased oxidative stress under hypoxic conditions via stimulation of Akt and eNOS (Hayashida et al. ). H 2 S has been implicated in hypoxia‐mediated damage by regulating functions of hypoxia‐inducible factors and acting as an important oxygen/hypoxia sensor (Yang et al.…”

Section: Mechanismsmentioning

confidence: 99%

“…Studies have shown H 2 S to decrease oxidation of low-density lipoprotein (LDL), uptake of oxidized LDL by macrophages, foam cell formation (Laggner et al 2007;Zhao et al 2011), and vascular calcification . Mice subjected to HLI treated with diallyl trisulfide (DATS), an organic polysulfide which liberates H 2 S, were show to have enhanced blood flow recovery and capillary density in ischemic limbs, as well as reduced oxidative stress in ischemic muscles (Hayashida et al 2017). Addition of DATS to cultured human umbilical vein endothelium cells also decreased oxidative stress under hypoxic conditions via stimulation of Akt and eNOS (Hayashida et al 2017 functions of hypoxia-inducible factors and acting as an important oxygen/hypoxia sensor (Yang et al 2015).…”

Section: H 2 Smentioning

confidence: 99%

“…Mice subjected to HLI treated with diallyl trisulfide (DATS), an organic polysulfide which liberates H 2 S, were show to have enhanced blood flow recovery and capillary density in ischemic limbs, as well as reduced oxidative stress in ischemic muscles (Hayashida et al 2017). Addition of DATS to cultured human umbilical vein endothelium cells also decreased oxidative stress under hypoxic conditions via stimulation of Akt and eNOS (Hayashida et al 2017 functions of hypoxia-inducible factors and acting as an important oxygen/hypoxia sensor (Yang et al 2015). Taken together, this emerging evidence suggests that changes in H 2 S may affect several different pathophysiological responses involved in atherosclerotic vessel diseases.…”

Section: H 2 Smentioning

confidence: 99%

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Oxidative stress and antioxidant treatment in patients with peripheral artery disease

et al. 2018

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Peripheral artery disease is an atherosclerotic disease of arterial vessels that mostly affects arteries of lower extremities. Effort induced cycles of ischemia and reperfusion lead to increased reactive oxygen species production by mitochondria. Therefore, the pathophysiology of peripheral artery disease is a consequence of metabolic myopathy, and oxidative stress is the putative major operating mechanism behind the structural and metabolic changes that occur in muscle. In this review, we discuss the evidence for oxidative damage in peripheral artery disease and discuss management strategies related to antioxidant supplementation. We also highlight the major pathways governing oxidative stress in the disease and discuss their implications in disease progression. Potential therapeutic targets and diagnostic methods related to these mechanisms are explored, with an emphasis on the Nrf2 pathway.

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Section: Mechanismsmentioning

confidence: 99%

Section: Mechanismsmentioning

confidence: 99%

Section: H 2 Smentioning

confidence: 99%

Section: H 2 Smentioning

confidence: 99%

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Oxidative stress and antioxidant treatment in patients with peripheral artery disease

et al. 2018

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“…Cardioprotective effect of garlic has been attributed to the antioxidant activities, 19 AMPK-regulated AKT/GSK-3β/HIF-1α pathway, 32 and Akt-eNOS signaling pathways. 33 However, it’s fully mechanisms is still in debate.…”

Section: Discussionmentioning

confidence: 99%

The impacts of garlic and voluntary training alone or together on myocardial miR-126 and miR-210 gene expressions and angiogenesis in healthy rats

Ghiasi

Alihemmati

Naderi

2020

J Cardiovasc Thorac Res

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Introduction: microRNAs (miRs) play a critical role in both physiological and pathological processes. Recent studies have shown that garlic and exercise training have many beneficial effects in different disorders including cardiovascular disease. However, their mechanisms have not been fully understood. This study sought to investigate the impact of garlic and voluntary training alone or together on themiR-126 and miR-210 gene expressions and cardiac angiogenesis. Methods: Male Wistar rats were divided into four groups (n=7): (1) Control, (2) Garlic, (3) Exercise, and (4) Garlic+ Exercise. Animals were gavaged with raw fresh garlic homogenate (250 mg/kg body weight/day) or were subjected to voluntary training alone or together for about 6 weeks. The expressions of miR-126 and miR-210 in the heart tissue were measured by real-time PCR and lipid profile in serum was assessed by enzymatic kits. Angiogenesis was determined by immuno staining detection of PECAM-1 and CD31 in the heart tissue. Results: Garlic and exercise up-regulated myocardial miR-126 ( P < 0.01), miR-210 ( P < 0.001)expressions, and angiogenesis ( P < 0.001) which was evidenced by higher CD31 expression. Besides, combination of garlic and exercise amplified their effects on those parameters ( P < 0.001). Moreover, both voluntary exercise and garlic alone ( P < 0.01) or together ( P < 0.001) markedly modulated serum lipid profile. Conclusion: Voluntary exercise and garlic treatment for 6 weeks enhanced myocardial angiogenesis. These alterations were partly due to the increment of miR-126 and miR-210 expressions in the heart tissue in relation to improvement in lipid profile.

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Antinociceptive effect of garlic, garlic preparations and derivative compounds

Hernández-Cruz

Silva-Islas

Maldonado

et al. 2022

European Journal of Pain

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Background and objective:The antinociceptive effects of garlic have shown promise in treating different chronic diseases in humans, such as knee osteoarthritis, rheumatoid arthritis and peripheral arterial occlusive disease stage II.The most common garlic products are garlic powder (dried garlic), steam distilled garlic oils, garlic oil macerate and aged garlic extract. These commercial products contain organosulphur compounds (OSCs) that have been extensively evaluated in preclinical models and some clinical assays to treat different diseases against pain. In this review, we describe the importance of some bioactive compounds found in garlic and their role in treating pain. Materials & Methods:A systematic search of the literature in Dimensions, PubMed, Scopus, and Web of Science was performed. Terms and preselected keywords relating to garlic, its derivatives and organusulphure compounds in acute, chronic and neuropathic pain, were used to perform a systematic literature search. Two independent reviewers screened the papers for inclusion and assessed the methodological quality. Results & Discussion:The antinociceptive activity of garlic and its OSC is related to its antioxidant and anti-inflammatory properties, which may be explained by the ability to block the synthesis of PGs, pro-inflammatory cytokines and interferon-γ, by the reduction COX-2 activity and increasing the levels of anti-inflammatory cytokines. Besides, garlic extract is an activator of TRPA1 and TRPV1, where the principal responsible for this activation are OSC. Conclusion:The relationship between these pathways allows a better understanding how garlic and its derivates could be carrying out its pharmacological action over the management of acute and chronic pain and provide a base by further investigations.Significance: Antinociceptive effect of garlic and its OSCs has been extensively evaluated in preclinical models and clinical assays to treat different diseases, contributing to the modulation of inflammation as an essential factor in reducing pain. The current review emphasizes the potential therapeutic effect of garlic and its derivatives in treatment of pain and related mechanisms of action. Moreover, it provides information about the potential clinical use in patients with painful conditions.

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Diallyl Trisulfide Augments Ischemia-Induced Angiogenesis via an Endothelial Nitric Oxide Synthase-Dependent Mechanism

Cited by 43 publications

References 41 publications

Oxidative stress and antioxidant treatment in patients with peripheral artery disease

Oxidative stress and antioxidant treatment in patients with peripheral artery disease

The impacts of garlic and voluntary training alone or together on myocardial miR-126 and miR-210 gene expressions and angiogenesis in healthy rats

Antinociceptive effect of garlic, garlic preparations and derivative compounds

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