The impacts of garlic and voluntary training alone or together on myocardial miR-126 and miR-210 gene expressions and angiogenesis in healthy rats

Ghiasi, Rafighe; Alihemmati, Alireza; Naderi, Roya

doi:10.34172/jcvtr.2020.33

Cited by 3 publications

(7 citation statements)

References 45 publications

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“…In this chapter, we have discussed the regulatory networks, specifically related to the SIRT1/eNOS signaling pathway, mediated by several natural antioxidants via expression of CVD-related miRNAs, which have already been discussed in Chapter 3 ( Table 2). [163,164] Down Crocin, Saponin [184,185] miR-145 -Up Gallic acid [172] Up EGCG [186] Up Geniposide [187] miR-210 -Up Garlic [42] -Up Crocin [188] miR-126…”

Section: The Regulation Of Cvd-related Mirnas By Natural Antioxidantsmentioning

confidence: 99%

“…miR-210 is a well-known master miRNA involved in the elicitation of hypoxic responses because its expression is upregulated by hypoxia in all the cell types analyzed thus far [ 4 , 42 ]. The expression of miR-210 in endothelial cells is increased under hypoxia conditions [ 85 ].…”

Section: Cvd-related Mirnas Target Enos and Sirt1mentioning

confidence: 99%

“…Garlic is a natural component enriched in phenolic acid that provides considerable health benefits including the prevention and treatment of several disorders such as CVDs [ 201 ]. Garlic treatment increased the expression of miR-126 and miR-210 in rat myocardial tissue, enhanced cardiac angiogenesis, and improved serum lipid profile [ 42 ].…”

Section: The Regulation Of Cvd-related Mirnas By Natural Antioxidamentioning

confidence: 99%

“…miR-221 and its paralogue miR-222 are highly expressed in endothelial cells and show notable activities in the vascular network by influencing the angiogenic properties of endothelial cells [ 28 , 40 ]. miR-210 is associated with angiogenesis and enhances microcirculation under both physiological and pathophysiological conditions [ 41 , 42 ]. miR-126 is considered a pivotal endothelial-specific miRNA, one of the most abundantly expressed in vascularized tissues and endothelial cells, and is involved in cardiac angiogenesis [ 12 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

“…miR-210 is associated with angiogenesis and enhances microcirculation under both physiological and pathophysiological conditions [ 41 , 42 ]. miR-126 is considered a pivotal endothelial-specific miRNA, one of the most abundantly expressed in vascularized tissues and endothelial cells, and is involved in cardiac angiogenesis [ 12 , 42 ]. Alteration of the miR-21, miR-199a, miR-34a, and miR-145 expression levels has also been linked to a variety of cardiac injuries, with the levels showing increases in the affected cardiac tissue [ 43 , 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

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Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS

Lee

2021

Antioxidants

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Cardiovascular diseases (CVDs) are the most common cause of morbidity and mortality worldwide. The potential benefits of natural antioxidants derived from supplemental nutrients against CVDs are well known. Remarkably, natural antioxidants exert cardioprotective effects by reducing oxidative stress, increasing vasodilation, and normalizing endothelial dysfunction. Recently, considerable evidence has highlighted an important role played by the synergistic interaction between endothelial nitric oxide synthase (eNOS) and sirtuin 1 (SIRT1) in the maintenance of endothelial function. To provide a new perspective on the role of natural antioxidants against CVDs, we focused on microRNAs (miRNAs), which are important posttranscriptional modulators in human diseases. Several miRNAs are regulated via the consumption of natural antioxidants and are related to the regulation of oxidative stress by targeting eNOS and/or SIRT1. In this review, we have discussed the specific molecular regulation of eNOS/SIRT1-related endothelial dysfunction and its contribution to CVD pathologies; furthermore, we selected nine different miRNAs that target the expression of eNOS and SIRT1 in CVDs. Additionally, we have summarized the alteration of miRNA expression and regulation of activities of miRNA through natural antioxidant consumption.

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Section: The Regulation Of Cvd-related Mirnas By Natural Antioxidantsmentioning

confidence: 99%

Section: Cvd-related Mirnas Target Enos and Sirt1mentioning

confidence: 99%

Section: The Regulation Of Cvd-related Mirnas By Natural Antioxidamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS

Lee

2021

Antioxidants

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MicroRNAs regulating signaling pathways in cardiac fibrosis: potential role of the exercise training

Improta-Caria,

Rodrigues,

Joaquim

et al. 2024

American Journal of Physiology-Heart and Circulatory Physiology

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Cardiovascular and metabolic diseases such as hypertension, type 2 diabetes, and obesity develop long-term fibrotic processes in the heart, promoting pathological cardiac remodeling, including after myocardial infarction, reparative fibrotic processes also occur. These processes are regulated by many intracellular signaling pathways that have not yet been completely elucidated, including those associated with microRNA (miRNA) expression. miRNAs are small RNA transcripts (18-25 nucleotides in length) that act as post-transcriptionally regulators of gene expression, inhibiting or degrading one or more target messenger RNAs (mRNAs), and proven to be involved in many biological processes such as cell cycle, differentiation, proliferation, migration, and apoptosis, directly affecting the pathophysiology of several diseases, including cardiac fibrosis. Exercise training can modulate the expression of miRNAs and it is known to be beneficial in various cardiovascular diseases, attenuating cardiac fibrosis processes. However, the signaling pathways modulated by the exercise associated with miRNAs in cardiac fibrosis were not fully understood. Thus, this review aims to analyze the expression of miRNAs that modulate signaling pathways in cardiac fibrosis processes that can be regulated by exercise training.

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Exercise-Induced miR-210 Promotes Cardiomyocyte Proliferation and Survival and Mediates Exercise-Induced Cardiac Protection against Ischemia/Reperfusion Injury

Bei,

Wang,

Liu

et al. 2024

Research

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Exercise can stimulate physiological cardiac growth and provide cardioprotection effect in ischemia/reperfusion (I/R) injury. MiR-210 is regulated in the adaptation process induced by exercise; however, its impact on exercise-induced physiological cardiac growth and its contribution to exercise-driven cardioprotection remain unclear. We investigated the role and mechanism of miR-210 in exercise-induced physiological cardiac growth and explored whether miR-210 contributes to exercise-induced protection in alleviating I/R injury. Here, we first observed that regular swimming exercise can markedly increase miR-210 levels in the heart and blood samples of rats and mice. Circulating miR-210 levels were also elevated after a programmed cardiac rehabilitation in patients that were diagnosed of coronary heart diseases. In 8-week swimming model in wild-type (WT) and miR-210 knockout (KO) rats, we demonstrated that miR-210 was not integral for exercise-induced cardiac hypertrophy but it did influence cardiomyocyte proliferative activity. In neonatal rat cardiomyocytes, miR-210 promoted cell proliferation and suppressed apoptosis while not altering cell size. Additionally, miR-210 promoted cardiomyocyte proliferation and survival in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and AC16 cell line, indicating its functional roles in human cardiomyocytes. We further identified miR-210 target genes, cyclin-dependent kinase 10 (CDK10) and ephrin-A3 (EFNA3), that regulate cardiomyocyte proliferation and apoptosis. Finally, miR-210 KO and WT rats were subjected to swimming exercise followed by I/R injury. We demonstrated that miR-210 crucially contributed to exercise-driven cardioprotection against I/R injury. In summary, this study elucidates the role of miR-210, an exercise-responsive miRNA, in promoting the proliferative activity of cardiomyocytes during physiological cardiac growth. Furthermore, miR-210 plays an essential role in mediating the protective effects of exercise against cardiac I/R injury. Our findings suggest exercise as a potent nonpharmaceutical intervention for inducing miR-210, which can alleviate I/R injury and promote cardioprotection.

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The impacts of garlic and voluntary training alone or together on myocardial miR-126 and miR-210 gene expressions and angiogenesis in healthy rats

Cited by 3 publications

References 45 publications

Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS

Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS

MicroRNAs regulating signaling pathways in cardiac fibrosis: potential role of the exercise training

Exercise-Induced miR-210 Promotes Cardiomyocyte Proliferation and Survival and Mediates Exercise-Induced Cardiac Protection against Ischemia/Reperfusion Injury

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