Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS

Lee, Yunna

doi:10.3390/antiox10030377

Cited by 33 publications

(20 citation statements)

References 227 publications

(359 reference statements)

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“…These genes are located on the same seed sequence and separated by 726 nucleotide bases. Under normal conditions, miR-221 and miR-222 are known to regulate a variety of important physiological vascular processes, such as angiogenesis, neointimal hyperplasia, vascular wound healing, vascular aging, and atherosclerotic vascular remodeling [ 41 ]. This gene cluster has been extensively studied in various malignancies in humans [ 39 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

microRNA-221 and tamoxifen resistance in luminal-subtype breast cancer patients: A case-control study

Amiruddin

Massi

Islam

et al. 2022

Annals of Medicine &Amp; Surgery

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Background Around 70% of breast cancers (BCs) are estrogen receptor-α (ERα)-positive. Adjuvant endocrine therapy is used to reduce estrogen levels and inhibit signal transduction through the ER. The anti-estrogen drugs that are most commonly used in endocrine therapy belong to the selective ER modulator (SERM) class and include tamoxifen. Although it has been used for three decades in cases of early-stage and ERα-positive BC, resistance to tamoxifen is a common problem. microRNAs (miRNAs) have a potential role in demonstrating BC resistance to tamoxifen therapy. Hence, there is a need to investigate the expression of miRNA-221 (miR-221) in luminal-subtype BC patients receiving tamoxifen therapy. Methods This case-control study investigated luminal-subtype BC patients who had undergone endocrine therapy for at least 1 year. The case group comprised patients with local or metastatic recurrence, and the control group comprised patients without local or metastatic recurrence. Results There was a significant difference in miR-221 expression ( p = 0.005) between the case and control groups. There were no significant differences between the groups that were positive and negative for the progesterone receptor (PR) ( p = 0.25), had high and low marker of proliferation Ki-67 levels ( p = 0.60), were positive and negative for lymphovascular invasion ( p = 0.14), and had stage 2 and stage 3 cancer ( p = 0.25). Conclusion miR-221 expression was higher in tamoxifen-resistant BC cases. miR-221 is a potential biomarker of tamoxifen resistance.

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Section: Discussionmentioning

confidence: 99%

microRNA-221 and tamoxifen resistance in luminal-subtype breast cancer patients: A case-control study

Amiruddin

Massi

Islam

et al. 2022

Annals of Medicine &Amp; Surgery

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“…A balanced intake of phosphorus, zinc, and selenium ensures good intestinal health. − In addition, in recent years, miRNAs have been extensively studied as new media that participate in the regulation of food nutrition . Nutrients play crucial roles in altering the miRNA profile and subsequently exert antitumor activity, an antioxidative response, a neuroprotective effect, an attenuating chronic inflammatory reaction, immune regulation, etc. − In conclusion, the types and quantity of intake of traditional nutrients and plant active compounds in plants have profound effects on endogenous miRNAs, GM, and human health. However, the interactions and casual relationship of plant compounds with human health, their quantitative effect, and mechanisms of action need to be studied in detail to improve edible plants’ breeding and dietary combinations.…”

Section: Effect Of Mirnas On the Nutritional Quality Of Plantsmentioning

confidence: 99%

Insights into Health-Promoting Effects of Plant MicroRNAs: A Review

Zhu

Liu

Cao

et al. 2021

J. Agric. Food Chem.

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Plant-derived microRNAs (miRNAs) play a significant role in human health and are “dark nutrients”, as opposed to traditional plant nutrients, as well as important components of food diversification. Studies have revealed that multiple plant-derived miRNA pathways affect human health. First, plant miRNAs regulate plant growth and development and accumulation of metabolites, which alters the food quality and thus indirectly interferes with the health of the host. Moreover, when absorbed in vivo, some miRNAs may target the host cell mRNAs to affect protein expression. In addition, plant miRNAs target and reshape the human gut microbiota (GM), which interferes with the physiology and metabolism of the host. Therefore, miRNAs play a significant role in the cross-kingdom communication of plants, GM, and the host and in maintaining a balance of the three. Future contributions of plant miRNAs can bring new perspectives and opportunities to better understand food nutrition and health care research, which will facilitate the right exploitation of plant resources.

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“…[59] The renin-angiotensin-aldosterone (RAA) system is the major regulator of salt and water metabolism in the body and the most important endocrine system in controlling blood pressure . [60] The disturbed balance of this system, as a result of the factors for the reabsorption of water and salts in the organism, [61] leads to vasospasm, thrombosis, atherosclerosis, and restenosis after invasive procedures. Increased hypercoagulability has been reported in patients with essential hypertension, which is one of the most important risk factors for cardiovascular disease.…”

Section: Anti-atherosclerotic Effects Of Curcuminmentioning

confidence: 99%

Application of curcumine and its derivatives in the treatment of cardiovascular diseases: a review

Stamenkovska

Hadzi‐Petrushev

Nikodinovski

et al. 2021

International Journal of Food Properties

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Cardiovascular diseases are the leading cause of death in the world and scientists pay a lot of attention to identify and reveal the mechanisms of their occurrence. Recently, the attention of scientists is focused increasingly on plant derivatives, such as flavonoids and polyphenols, due to their specific biological effects. One of these compounds is curcumin, which has many biological properties. Numerous studies have been performed to understand the molecular basis of the therapeutic properties of curcumin. As a result of these studies, there is considerable evidence to suggest that curcumin may affect signaling pathways associated with the cell growth, proliferation, survival, inflammation, and gene transcription. Antioxidant and antiinflammatory mechanisms are the two basic mechanisms to which many of the effects of curcumin in various conditions are attributed. Many factors influence the development of heart disease, but one of the main culprits in their occurrence is the inflammatory process. According to recent research, curcumin is an ingredient that could be used in the prevention or treatment of cardiovascular disease. Also, some studies have shown that it has beneficial effects in preventing vascular damage and ischemia. Despite its beneficial and biological properties, it has been proven that curcumin has relatively low bioavailability and low stability in the human body, which limits its therapeutic application. In this regard, several attempts have been made to synthesize curcumin derivatives with improved bioavailability. In this paper, we review the potential and possibilities of using curcumin and its derivatives in the treatment of cardiovascular disease, which would significantly reduce the mortality rate in the population. Based on all of the above, it can be concluded that further studies of animal models and humans are needed to verify current knowledge about the application of curcumin and its derivatives in the treatment of cardiovascular diseases. In this way through these studies more reliable data will be generated concerning the effects of curcumin and its analogs on cellular and subcellular/molecular levels. Prospectively, we believe that this will ground the basis for further improved synthesis of curcumin-analogs, appropriate for the treatment of cardiovascular diseases.

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Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS

Cited by 33 publications

References 227 publications

microRNA-221 and tamoxifen resistance in luminal-subtype breast cancer patients: A case-control study

microRNA-221 and tamoxifen resistance in luminal-subtype breast cancer patients: A case-control study

Insights into Health-Promoting Effects of Plant MicroRNAs: A Review

Application of curcumine and its derivatives in the treatment of cardiovascular diseases: a review

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