Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide

Tsai, Cheng Yen; Su, Wen; Shibu, Marthandam Asokan; Yang, Yanyan; Peng, Hanjing; Wang, Binghe; Wei, Yu Min; Chang, Hsuan; Lee, Cheng-Yu; Huang, Chih Yang; Kuo, Wei Wen

doi:10.1016/j.ijcard.2015.05.111

Cited by 66 publications

(43 citation statements)

References 38 publications

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“…The hyperglycemic sham arm presented with the highest overall metabolic rate, i.e., CO 2 production (VCO 2 ), indicating that substrates were being cleared rather than accumulated, thus helping to explain the low levels of ADRP expression in the livers. In contrast to our study, all previous experiments that have shown a downregulation of CSE by high glucose have been performed in isolated cell systems in vitro [6, 7, 36]. …”

Section: Discussionmentioning

confidence: 83%

Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock

Merz

Vogt

Wachter

et al. 2017

ICMx

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BackgroundCystathionine-γ-lyase (CSE) was shown to have a regulatory role in glucose metabolism. Circulatory shock can induce metabolic stress, thereby leading to hyperglycemia and mitochondrial dysfunction. In vitro data suggest an effect of high glucose on CSE expression. Therefore, the aim of this study was to investigate the effects of hyperglycemia on CSE expression in resuscitated murine septic shock.MethodsNormo- (80–150 mg/dl) and hyperglycemic (>200 mg/dl) male C57/BL6J mice (n = 5-6 per group) underwent cecal ligation and puncture (CLP)-induced polymicrobial sepsis or sham procedure (n = 6 per group) and, 15 h afterwards, were anesthetized again, surgically instrumented and received intensive care treatment, including antibiotics, lung protective mechanical ventilation, circulatory support, and intravenous (i.v.) glucose infusion (50% as stable-isotope labeled 1,2,3,4,5,6–13C6 glucose). Blood and breath gas were sampled hourly to quantify parameters of glucose metabolism. 5 h later, mice were sacrificed and organs were harvested. The liver mitochondrial respiratory activity was determined via high resolution respirometry; CSE, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), and adipocyte differentiation-related protein (ADRP) expression was immunohistochemically investigated.ResultsIn sepsis combined with hyperglycemia the least CSE and PGC1α expression could be detected, along with reduced mitochondrial respiratory activity, and enhanced ADRP expression, a marker of lipid droplet formation, in the liver. A novel in vivo finding is the CSE translocation from the cytosol to the nucleus triggered by metabolic stress.ConclusionsA relationship between CSE and glucose metabolism was established, which, when dysregulated, may contribute to fatty liver disease and hepatic steatosis.

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Section: Discussionmentioning

confidence: 83%

Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock

Merz

Vogt

Wachter

et al. 2017

ICMx

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“…Results from in vivo studies using SPRC provided additional evidence for its CSE-mediated effects, as PAG inhibited angiogenesis in an Matrigel® plug model [96]. Since other H 2 S donors have been shown to increase CSE expression under certain conditions [97], it is possible that endogenous H 2 S contributes to the angiogenic effects of some H 2 S donors. It should also be mentioned that NO donors require the presence of endogenous H 2 S to exert their angiogenic effects.…”

Section: Pharmacological Agents That Promote Angiogenesis Through Endmentioning

confidence: 99%

Regulation and role of endogenously produced hydrogen sulfide in angiogenesis

Katsouda

Bibli

Pyriochou

et al. 2016

Pharmacological Research

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Recent studies have implicated endogenously produced H2S in the angiogenic process. On one hand, pharmacological inhibition and silencing of the enzymes involved in H2S synthesis attenuate the angiogenic properties of endothelial cells, including proliferation, migration and tube-like structure network formation. On the other hand, enhanced production of H2S by substrate supplementation or over-expression of H2S-producing enzymes leads to enhanced angiogenic responses in cultured endothelial cells. Importantly, H2S up-regulates expression of the key angiogenic factor vascular endothelial growth factor (VEGF) and contributes to the angiogenic signaling in response to VEGF. The signaling pathways mediating H2S-induced angiogenesis include mitogen-activated protein kinases, phosphoinositide-3 kinase, nitric oxide/cGMP-regulated cascades and ATP-sensitive potassium channels. Endogenously produced H2S has also been shown to facilitate neovascularization in prototypical model systems in vivo, and to contribute to wound healing, post-ischemic angiogenesis in the heart and other tissues, as well as in tumor angiogenesis. Targeting of H2S synthesizing enzymes might offer novel therapeutic opportunities for angiogenesis-related diseases.

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“…ATB-346 [2-(6-methoxynapthalen-2-yl)-propionic acid 4-thiocarbamoyl phenyl ester], an H 2 S-releasing donor with COX inhibition effects, offers superior anti-inflammatory and anti-nociceptive activity, meanwhile, ATB-346 also has better chondroprotective effects than naproxen but without detrimental effects [37]. Diallyl disulfide and diallyl trisulfide are organosulfur compounds found in members of allium species such as garlic (Allium sativum), onion (Allium cepa), chives (Allium schoenoprasum) etc., that act as H 2 S donors and also have antioxidant, anti-inflammatory, cytoprotective, and cardioprotectionproperties [38]. H 2 S-releasing diclofenac derivatives (ACS15 and ACS32) inhibit osteoclast formation and its activity subsequently prevents the process of osteolysis, can be a potential candidate for the clinical treatment of osteolytic bone disease [39].…”

Section: H2s Formation Oxidation Toxicity and Physiological Funmentioning

confidence: 99%

Cross-talk of MicroRNA and hydrogen sulfide: A novel therapeutic approach for bone diseases

Zhai

Tyagi

2017

Biomedicine & Pharmacotherapy

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Bone homeostasis requires a balance between the bone formation of osteoblasts and bone resorption of osteoclasts to maintain ideal bone mass and bone quality. An imbalance in bone remodeling processes results in bone metabolic disorders such as osteoporosis. Hydrogen sulfide (H2S), a gasotransmitter, has attracted the focus of many researchers due to its multiple physiological functions. It has been implicated in anti-inflammatory, vasodilatory, angiogenic, cytoprotective, anti-oxidative and anti-apoptotic mechanisms. H2S has also been shown to exert osteoprotective activity through its anti-inflammatory and anti-oxidative effects. However, the underlying molecular mechanisms by which H2S mitigates bone diseases are not completely understood. Experimental evidence suggests that H2S may regulate signaling pathways by directly influencing a gene in the cascade or interacting with some other gasotransmitter (carbon monoxide or nitric oxide) or both. MicroRNAs (miRNAs) are short non-coding RNAs which regulate gene expression by targeting, binding and suppressing mRNAs; thus controlling cell fate. Certainly, bone remodeling is also regulated by miRNAs expression and has been reported in many studies. MicroRNAs also regulate H2S biosynthesis. The inter-regulation of microRNAs and H2S opens a new possibility for exploring the H2S-microRNA crosstalk in bone diseases. However, the relationship between miRNAs, bone development, and H2S is still not well explained. This review focuses on miRNAs and their roles in regulating bone remodeling and possible mechanisms behind H2S mediated bone loss inhibition, H2S-miRNAs crosstalk in relation to the pathophysiology of bone remodeling, and future perspectives for miRNA-H2S as a therapeutic agent for bone diseases.

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Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide

Cited by 66 publications

References 38 publications

Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock

Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock

Regulation and role of endogenously produced hydrogen sulfide in angiogenesis

Cross-talk of MicroRNA and hydrogen sulfide: A novel therapeutic approach for bone diseases

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