Dialysers

Hoenich, Nicholas A.; Woffindin, C.; Ward, M. K.

doi:10.1007/978-94-009-1087-4_5

Cited by 8 publications

(2 citation statements)

References 108 publications

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“…The internal flow resistance with a large width to height ratio is dependent upon the viscosity, path length, blood flow rate and width to height dimensions 6 . Therefore, by manipulating the height and width of the flat plate channel the internal resistance can be significantly reduced, negating the need for an external blood pump.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy

et al. 2016

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Silicon nanopore membranes (SNM) with compact geometry and uniform pore size distribution have demonstrated a remarkable capacity for hemofiltration. These advantages could potentially be used for hemodialysis. Here we present an initial evaluation of the SNM’s mechanical robustness, diffusive clearance, and hemocompatibility in a parallel plate configuration. Mechanical robustness of the SNM was demonstrated by exposing membranes to high flows (200ml/min) and pressures (1,448mmHg). Diffusive clearance was performed in an albumin solution and whole blood with blood and dialysate flow rates of 25ml/min. Hemocompatibility was evaluated using scanning electron microscopy and immunohistochemistry after 4-hours in an extra-corporeal porcine model. The pressure drop across the flow cell was 4.6mmHg at 200ml/min. Mechanical testing showed that SNM could withstand up to 775.7mmHg without fracture. Urea clearance did not show an appreciable decline in blood versus albumin solution. Extra-corporeal studies showed blood was successfully driven via the arterial-venous pressure differential without thrombus formation. Bare silicon showed increased cell adhesion with a 4.1 fold increase and 1.8 fold increase over polyethylene-glycol (PEG)-coated surfaces for tissue plasminogen factor (t-PA) and platelet adhesion (CD-41), respectively. These initial results warrant further design and development of a fully scaled SNM-based parallel plate dialyzer for renal replacement therapy.

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Section: Introductionmentioning

confidence: 99%

Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy

et al. 2016

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“…Since HD requires rapid extracorpor eal blood flow [ 1 ], femoral [2], subclavian [3.4], and inter nal jugular [5,6] veins are the sites most commonly cho sen. Several factors preclude the wider use of indwelling femoral catheters for HD. including interference with ambulation and concern over bleeding, infection, and deep venous thrombosis [7],…”

Section: Introductionmentioning

confidence: 99%

Carotid-Jugular Arteriovenous Fistula: A Complication of Temporary Hemodialysis Catheter

El-Shahawy

Khilnani²

1995

Am J Nephrol

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The internal jugular vein is increasingly being used as a temporary route for dual-lumen hemodialysis catheter placement. It is thought to be safer than the subclavian or femoral vein sites. It is important, however, to point out that this route can also be associated with serious complications. Herein we describe a case of right common carotid artery fistula as a complication of the insertion of a polyurethane double-lumen hemodialysis catheter into the right internal jugular vein. A review of the literature on traumatic complications associated with central venous cannulation is also presented.

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What do we mean by a statistical model?

Appleton

1995

Statistics in Medicine

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Statisticians are too often satisfied by fitting data rather than investigating the process out of which the data arose. The assumptions on which they base their models may be quite unrealistic, and while it is true that a model should not be more complicated than necessary, neither should it be too simple. Ways of approaching several sets of data from different areas of clinical medicine are considered, and different attitudes to the purpose of modelling highlighted. The transition from smoothing data, through fitting curves, to modelling underlying processes is discussed.

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Dialysers

Cited by 8 publications

References 108 publications

Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy

Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy

Carotid-Jugular Arteriovenous Fistula: A Complication of Temporary Hemodialysis Catheter

What do we mean by a statistical model?

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