Diammonium glycyrrhizinate, a component of traditional Chinese medicine Gan-Cao, prevents murine T-cell-mediated fulminant hepatitis in IL-10- and IL-6-dependent manners

Hepatic protection by glycyrrhizin and inhibition of iNOS expression in concanavalin A-induced liver injury in mice

“…GL, an antiinflammatory agent [27,28] of licorice root, has been reported to prevent Con A-induced mouse liver injury without affecting the production of cytokines such as IFN-c and TNF-a [2]. However, there is evidence that the production of IL-6 and IL-10 in the livers of mice treated with Con A is improved by GL treatment [29]. Our recent report has shown that GL inhibits increased IL-18 and matrix metalloproteinase-9 production in mice treated with LPS/GalN [8,9].…”

A Chinese Decoction, Kuan-Sin-Yin, Improves Autonomic Function and Cancer-Related Symptoms of Metastatic Colon Cancer

“…Each of the components has been shown to have pharmacological activity in modulating the immune system and to have anti-inflammatory or antioxidant properties or both. [16][17][18][19][20][21][22] The purity of the KSY was evaluated by screening ingredients for contamination by heavy metals and pesticides and by a microbial limit test. Standard contents and quality control were analyzed by Internal Transcribed Space (ITS) technology and high-performance liquid chromatography (HPLC) at the Industrial Technology Research Institute, Hsinchu, Taiwan.We used ITS to analyze each of the 7 component ingredients in KSY to establish their DNA sequence, then analyzed the final KSY decoction using HPLC-PCA.…”

Metabolic profiling reveals the protective effect of diammonium glycyrrhizinate on acute hepatic injury induced by carbon tetrachloride

“…INTRODUCTION Diammonium glycyrrhizinate (DG), a purified effective constituent of the traditional Chinese medicinal herb Glycyrrhiza uralensis (liquorices or Gan-Cao) is clinically used in the treatment of hepatic injury, hepatisis and cirrhosis (Feng et al 2007). DG possesses a high antiinflammatory effect, which protects the hepatic cell membrane, and ameliorates liver function (Xu et al 2009;Yuan et al 2006).…”