2016
DOI: 10.1149/2.1211606jes
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Diaphorase-Viologen Conjugates as Bioelectrocatalysts for NADH Regeneration

Abstract: Redox enzymes are widely used as powerful biocatalysts owing to their high selectivity and sustainability. Since most of the enzymatic reactions require the expensive coenzyme (the reduced form of nicotinamide adenine dinucleotide, NADH) in a stoichiometric amount, efficient NADH regeneration is essential for various biocatalytic syntheses. Even though an electroenzymatic recycling method has many advantages, it requires low-molecular-weight redox mediators to transfer electrons from electrodes to an enzymes' … Show more

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Cited by 12 publications
(9 citation statements)
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“…A similar argument holds for surfaces modified by immobilized enzymes or metal complexes . Both electroenzymatic and enzyme‐supported NADH regeneration processes have also been reported, though these studies often sacrifice turnover frequency for selectivity and low applied potential, or vice versa . Consequently, several studies began focusing on “all‐solid” systems for electrochemical NADH regeneration.…”
Section: Introductionmentioning
confidence: 99%
“…A similar argument holds for surfaces modified by immobilized enzymes or metal complexes . Both electroenzymatic and enzyme‐supported NADH regeneration processes have also been reported, though these studies often sacrifice turnover frequency for selectivity and low applied potential, or vice versa . Consequently, several studies began focusing on “all‐solid” systems for electrochemical NADH regeneration.…”
Section: Introductionmentioning
confidence: 99%
“…NADH can also be regenerated by electrochemistry based on the mediator-conjugated diaphorase system ( Fig. 2 h) [ 89 ]. Among all hydrogen-donor compounds, renewable sugars have the lowest substrate costs, but they require more enzymes and increase system complexity.…”
Section: Basic Design Principles For In Vitro Syntmentioning
confidence: 99%
“…Also, NADPH is too expensive to use on a large scale. Therefore, NADP + reduction (i.e., NADPH recycling) is crucial for the utilization of NADPH-dependent enzymes [ 9 13 ]. Electrochemistry is often used to transfer electrons for various substances.…”
Section: Introductionmentioning
confidence: 99%
“…Electrochemistry is often used to transfer electrons for various substances. However, because the structure of NADP is complex, electron transport generally requires an enzyme that can exchange NADP + to NADPH [ 9 13 ]. The direct exchange of electrons with an electrode is difficult.…”
Section: Introductionmentioning
confidence: 99%
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